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Q8DTW7

- Q8DTW7_STRMU

UniProt

Q8DTW7 - Q8DTW7_STRMU

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Protein
Branched-chain-amino-acid aminotransferase
Gene
ilvE, SMU_1203
Organism
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate.UniRule annotation
L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate.UniRule annotation
L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.

Pathwayi

GO - Molecular functioni

  1. L-isoleucine transaminase activity Source: UniProtKB-EC
  2. L-leucine transaminase activity Source: UniProtKB-EC
  3. L-valine transaminase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. isoleucine biosynthetic process Source: UniProtKB-UniPathway
  2. leucine biosynthetic process Source: UniProtKB-UniPathway
  3. valine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

AminotransferaseUniRule annotationImported, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Branched-chain amino acid biosynthesisUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciSMUT210007:GC7Z-1142-MONOMER.
UniPathwayiUPA00047; UER00058.
UPA00048; UER00073.
UPA00049; UER00062.

Names & Taxonomyi

Protein namesi
Recommended name:
Branched-chain-amino-acid aminotransferaseUniRule annotation (EC:2.6.1.42UniRule annotation)
Gene namesi
Name:ilvEImported
Ordered Locus Names:SMU_1203Imported
OrganismiStreptococcus mutans serotype c (strain ATCC 700610 / UA159)Imported
Taxonomic identifieri210007 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002512: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei184 – 1841N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi210007.SMU.1203.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4DQNX-ray1.97A2-341[»]
ProteinModelPortaliQ8DTW7.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK00826.
OMAiFRPTKNA.
OrthoDBiEOG67MF3R.
PhylomeDBiQ8DTW7.

Family and domain databases

InterProiIPR001544. Aminotrans_IV.
IPR018300. Aminotrans_IV_CS.
IPR005786. B_amino_transII.
[Graphical view]
PANTHERiPTHR11825. PTHR11825. 1 hit.
PfamiPF01063. Aminotran_4. 1 hit.
[Graphical view]
PIRSFiPIRSF006468. BCAT1. 1 hit.
SUPFAMiSSF56752. SSF56752. 1 hit.
TIGRFAMsiTIGR01123. ilvE_II. 1 hit.
PROSITEiPS00770. AA_TRANSFER_CLASS_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8DTW7-1 [UniParc]FASTAAdd to Basket

« Hide

MTVDLDWKNL GFEYHKLPFR YISYYKDGKW DDGKLTEDAT LHISESSPAL    50
HYGQEAFEGL KAYRTKDGSV QLFRPNMNAE RLQRTADRLL MPQVPTDKFI 100
DAAKQVVRAN EEYVPPYGTG ATLYLRPLLI GVGDVIGVHP ADEYIFTIFA 150
MPVGNYFKGG LAPTNFLIQD DYDRAAPHGT GAAKVGGNYA ASLLPGKVAH 200
ERQFSDVIYL DPATHTKIEE VGSANFFGIT KDNEFITPLS PSILPSVTKY 250
SLLYLAEHRF GMKAIEGDVC VDELDKFVEA GACGTAAVIS PIGGVQHGDD 300
FHVFYSETEV GPVTHKLYDE LTGIQFGDVK APEGWIYKVD D 341
Length:341
Mass (Da):37,732
Last modified:March 1, 2003 - v1
Checksum:iEF5AAD29AEF56125
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014133 Genomic DNA. Translation: AAN58889.1.
RefSeqiNP_721583.1. NC_004350.2.

Genome annotation databases

EnsemblBacteriaiAAN58889; AAN58889; SMU_1203.
GeneIDi1029342.
KEGGismu:SMU_1203.
PATRICi19664495. VBIStrMut61772_1077.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014133 Genomic DNA. Translation: AAN58889.1 .
RefSeqi NP_721583.1. NC_004350.2.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4DQN X-ray 1.97 A 2-341 [» ]
ProteinModelPortali Q8DTW7.
ModBasei Search...

Protein-protein interaction databases

STRINGi 210007.SMU.1203.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN58889 ; AAN58889 ; SMU_1203 .
GeneIDi 1029342.
KEGGi smu:SMU_1203.
PATRICi 19664495. VBIStrMut61772_1077.

Phylogenomic databases

KOi K00826.
OMAi FRPTKNA.
OrthoDBi EOG67MF3R.
PhylomeDBi Q8DTW7.

Enzyme and pathway databases

UniPathwayi UPA00047 ; UER00058 .
UPA00048 ; UER00073 .
UPA00049 ; UER00062 .
BioCyci SMUT210007:GC7Z-1142-MONOMER.

Family and domain databases

InterProi IPR001544. Aminotrans_IV.
IPR018300. Aminotrans_IV_CS.
IPR005786. B_amino_transII.
[Graphical view ]
PANTHERi PTHR11825. PTHR11825. 1 hit.
Pfami PF01063. Aminotran_4. 1 hit.
[Graphical view ]
PIRSFi PIRSF006468. BCAT1. 1 hit.
SUPFAMi SSF56752. SSF56752. 1 hit.
TIGRFAMsi TIGR01123. ilvE_II. 1 hit.
PROSITEi PS00770. AA_TRANSFER_CLASS_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700610 / UA159.
  2. "Structure of the branched-chain aminotransferase from Streptococcus mutans."
    Ruan J., Hu J., Yin A., Wu W., Cong X., Feng X., Li S.
    Acta Crystallogr. D 68:996-1002(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.97 ANGSTROMS) OF 2-341.

Entry informationi

Entry nameiQ8DTW7_STRMU
AccessioniPrimary (citable) accession number: Q8DTW7
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: June 11, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome

External Data

Dasty 3

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