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Q8DTW7

- Q8DTW7_STRMU

UniProt

Q8DTW7 - Q8DTW7_STRMU

Protein

Branched-chain-amino-acid aminotransferase

Gene

ilvE

Organism
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate.
    L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate.
    L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate.

    Cofactori

    Pyridoxal phosphate.UniRule annotation
    Pyridoxal phosphate By similarity.

    Pathwayi

    GO - Molecular functioni

    1. L-isoleucine transaminase activity Source: UniProtKB-EC
    2. L-leucine transaminase activity Source: UniProtKB-EC
    3. L-valine transaminase activity Source: UniProtKB-EC

    GO - Biological processi

    1. isoleucine biosynthetic process Source: UniProtKB-UniPathway
    2. leucine biosynthetic process Source: UniProtKB-UniPathway
    3. valine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    AminotransferaseUniRule annotationImported, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Branched-chain amino acid biosynthesisUniRule annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotation

    Enzyme and pathway databases

    BioCyciSMUT210007:GC7Z-1142-MONOMER.
    UniPathwayiUPA00047; UER00058.
    UPA00048; UER00073.
    UPA00049; UER00062.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Branched-chain-amino-acid aminotransferaseUniRule annotation (EC:2.6.1.42UniRule annotation)
    Gene namesi
    Name:ilvEImported
    Ordered Locus Names:SMU_1203Imported
    OrganismiStreptococcus mutans serotype c (strain ATCC 700610 / UA159)Imported
    Taxonomic identifieri210007 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000002512: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei184 – 1841N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi210007.SMU.1203.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4DQNX-ray1.97A2-341[»]
    ProteinModelPortaliQ8DTW7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.UniRule annotation

    Phylogenomic databases

    KOiK00826.
    OMAiFRPTKNA.
    OrthoDBiEOG67MF3R.
    PhylomeDBiQ8DTW7.

    Family and domain databases

    InterProiIPR001544. Aminotrans_IV.
    IPR018300. Aminotrans_IV_CS.
    IPR005786. B_amino_transII.
    [Graphical view]
    PANTHERiPTHR11825. PTHR11825. 1 hit.
    PfamiPF01063. Aminotran_4. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006468. BCAT1. 1 hit.
    SUPFAMiSSF56752. SSF56752. 1 hit.
    TIGRFAMsiTIGR01123. ilvE_II. 1 hit.
    PROSITEiPS00770. AA_TRANSFER_CLASS_4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8DTW7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTVDLDWKNL GFEYHKLPFR YISYYKDGKW DDGKLTEDAT LHISESSPAL    50
    HYGQEAFEGL KAYRTKDGSV QLFRPNMNAE RLQRTADRLL MPQVPTDKFI 100
    DAAKQVVRAN EEYVPPYGTG ATLYLRPLLI GVGDVIGVHP ADEYIFTIFA 150
    MPVGNYFKGG LAPTNFLIQD DYDRAAPHGT GAAKVGGNYA ASLLPGKVAH 200
    ERQFSDVIYL DPATHTKIEE VGSANFFGIT KDNEFITPLS PSILPSVTKY 250
    SLLYLAEHRF GMKAIEGDVC VDELDKFVEA GACGTAAVIS PIGGVQHGDD 300
    FHVFYSETEV GPVTHKLYDE LTGIQFGDVK APEGWIYKVD D 341
    Length:341
    Mass (Da):37,732
    Last modified:March 1, 2003 - v1
    Checksum:iEF5AAD29AEF56125
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014133 Genomic DNA. Translation: AAN58889.1.
    RefSeqiNP_721583.1. NC_004350.2.

    Genome annotation databases

    EnsemblBacteriaiAAN58889; AAN58889; SMU_1203.
    GeneIDi1029342.
    KEGGismu:SMU_1203.
    PATRICi19664495. VBIStrMut61772_1077.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014133 Genomic DNA. Translation: AAN58889.1 .
    RefSeqi NP_721583.1. NC_004350.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4DQN X-ray 1.97 A 2-341 [» ]
    ProteinModelPortali Q8DTW7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 210007.SMU.1203.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN58889 ; AAN58889 ; SMU_1203 .
    GeneIDi 1029342.
    KEGGi smu:SMU_1203.
    PATRICi 19664495. VBIStrMut61772_1077.

    Phylogenomic databases

    KOi K00826.
    OMAi FRPTKNA.
    OrthoDBi EOG67MF3R.
    PhylomeDBi Q8DTW7.

    Enzyme and pathway databases

    UniPathwayi UPA00047 ; UER00058 .
    UPA00048 ; UER00073 .
    UPA00049 ; UER00062 .
    BioCyci SMUT210007:GC7Z-1142-MONOMER.

    Family and domain databases

    InterProi IPR001544. Aminotrans_IV.
    IPR018300. Aminotrans_IV_CS.
    IPR005786. B_amino_transII.
    [Graphical view ]
    PANTHERi PTHR11825. PTHR11825. 1 hit.
    Pfami PF01063. Aminotran_4. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006468. BCAT1. 1 hit.
    SUPFAMi SSF56752. SSF56752. 1 hit.
    TIGRFAMsi TIGR01123. ilvE_II. 1 hit.
    PROSITEi PS00770. AA_TRANSFER_CLASS_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700610 / UA159Imported.
    2. "Structure of the branched-chain aminotransferase from Streptococcus mutans."
      Ruan J., Hu J., Yin A., Wu W., Cong X., Feng X., Li S.
      Acta Crystallogr. D 68:996-1002(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.97 ANGSTROMS) OF 2-341.

    Entry informationi

    Entry nameiQ8DTW7_STRMU
    AccessioniPrimary (citable) accession number: Q8DTW7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 1, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3