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Protein

Ribose-5-phosphate isomerase A

Gene

rpiA

Organism
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.UniRule annotation

Catalytic activityi

D-ribose 5-phosphate = D-ribulose 5-phosphate.UniRule annotation

Pathwayi: pentose phosphate pathway

This protein is involved in step 1 of the subpathway that synthesizes D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Ribose-5-phosphate isomerase A (rpiA)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei104 – 1041Proton acceptorUniRule annotation
Binding sitei122 – 1221SubstrateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

BioCyciSMUT210007:GC7Z-1172-MONOMER.
BRENDAi5.3.1.6. 5941.
UniPathwayiUPA00115; UER00412.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribose-5-phosphate isomerase AUniRule annotation (EC:5.3.1.6UniRule annotation)
Alternative name(s):
Phosphoriboisomerase AUniRule annotation
Short name:
PRIUniRule annotation
Gene namesi
Name:rpiAUniRule annotation
Ordered Locus Names:SMU_1234
OrganismiStreptococcus mutans serotype c (strain ATCC 700610 / UA159)
Taxonomic identifieri210007 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000002512 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 225225Ribose-5-phosphate isomerase APRO_0000158473Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation1 Publication

Protein-protein interaction databases

STRINGi210007.SMU_1234.

Structurei

Secondary structure

1
225
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 1311Combined sources
Beta strandi21 – 244Combined sources
Helixi30 – 4415Combined sources
Beta strandi49 – 546Combined sources
Helixi55 – 6410Combined sources
Helixi71 – 733Combined sources
Beta strandi77 – 826Combined sources
Beta strandi85 – 873Combined sources
Helixi101 – 1099Combined sources
Beta strandi111 – 1199Combined sources
Helixi120 – 1223Combined sources
Beta strandi125 – 1273Combined sources
Beta strandi132 – 1365Combined sources
Helixi141 – 15010Combined sources
Beta strandi155 – 1573Combined sources
Beta strandi172 – 1765Combined sources
Helixi184 – 1929Combined sources
Beta strandi197 – 2037Combined sources
Beta strandi208 – 2147Combined sources
Turni215 – 2184Combined sources
Beta strandi219 – 2224Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3L7OX-ray1.70A/B1-225[»]
ProteinModelPortaliQ8DTT9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8DTT9.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni26 – 294Substrate bindingUniRule annotation
Regioni82 – 854Substrate bindingUniRule annotation
Regioni95 – 984Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the ribose 5-phosphate isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E66. Bacteria.
COG0120. LUCA.
KOiK01807.
OMAiGACHVQE.
OrthoDBiEOG67MF61.
PhylomeDBiQ8DTT9.

Family and domain databases

HAMAPiMF_00170. Rib_5P_isom_A.
InterProiIPR004788. Ribose5P_isomerase_typA.
IPR020672. Ribose5P_isomerase_typA_subgr.
[Graphical view]
PANTHERiPTHR11934. PTHR11934. 1 hit.
PfamiPF06026. Rib_5-P_isom_A. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00021. rpiA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8DTT9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEELKKIAGV RAAQYVEDGM IVGLGTGSTA YYFVEEVGRR VQEEGLQVIG
60 70 80 90 100
VTTSSRTTAQ AQALGIPLKS IDEVDSVDVT VDGADEVDPN FNGIKGGGGA
110 120 130 140 150
LLMEKIVGTL TKDYIWVVDE SKMVDTLGAF RLPVEVVQYG AERLFREFEK
160 170 180 190 200
KGYKPSFREY DGVRFVTDMK NFIIDLDLGS IPDPIAFGNM LDHQVGVVEH
210 220
GLFNGMVNRV IVAGKDGVRI LEANK
Length:225
Mass (Da):24,568
Last modified:March 1, 2003 - v1
Checksum:i06A854001BCE9D9B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014133 Genomic DNA. Translation: AAN58919.1.
RefSeqiNP_721613.1. NC_004350.2.
WP_002263209.1. NC_004350.2.

Genome annotation databases

EnsemblBacteriaiAAN58919; AAN58919; SMU_1234.
GeneIDi1028528.
KEGGismu:SMU_1234.
PATRICi19664555. VBIStrMut61772_1107.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014133 Genomic DNA. Translation: AAN58919.1.
RefSeqiNP_721613.1. NC_004350.2.
WP_002263209.1. NC_004350.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3L7OX-ray1.70A/B1-225[»]
ProteinModelPortaliQ8DTT9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi210007.SMU_1234.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN58919; AAN58919; SMU_1234.
GeneIDi1028528.
KEGGismu:SMU_1234.
PATRICi19664555. VBIStrMut61772_1107.

Phylogenomic databases

eggNOGiENOG4105E66. Bacteria.
COG0120. LUCA.
KOiK01807.
OMAiGACHVQE.
OrthoDBiEOG67MF61.
PhylomeDBiQ8DTT9.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00412.
BioCyciSMUT210007:GC7Z-1172-MONOMER.
BRENDAi5.3.1.6. 5941.

Miscellaneous databases

EvolutionaryTraceiQ8DTT9.

Family and domain databases

HAMAPiMF_00170. Rib_5P_isom_A.
InterProiIPR004788. Ribose5P_isomerase_typA.
IPR020672. Ribose5P_isomerase_typA_subgr.
[Graphical view]
PANTHERiPTHR11934. PTHR11934. 1 hit.
PfamiPF06026. Rib_5-P_isom_A. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00021. rpiA. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700610 / UA159.
  2. "Crystal structure of ribose-5-phosphate isomerase a from str mutans ua159."
    Fan X.X., Wang K.T., Su X.D.
    Submitted (DEC-2009) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS), SUBUNIT.

Entry informationi

Entry nameiRPIA_STRMU
AccessioniPrimary (citable) accession number: Q8DTT9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: March 1, 2003
Last modified: November 11, 2015
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.