Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ribose-5-phosphate isomerase A

Gene

rpiA

Organism
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.UniRule annotation

Catalytic activityi

D-ribose 5-phosphate = D-ribulose 5-phosphate.UniRule annotation

Pathwayi: pentose phosphate pathway

This protein is involved in step 1 of the subpathway that synthesizes D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Ribose-5-phosphate isomerase A (rpiA)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei104Proton acceptorUniRule annotation1
Binding sitei122SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

BRENDAi5.3.1.6. 5941.
UniPathwayiUPA00115; UER00412.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribose-5-phosphate isomerase AUniRule annotation (EC:5.3.1.6UniRule annotation)
Alternative name(s):
Phosphoriboisomerase AUniRule annotation
Short name:
PRIUniRule annotation
Gene namesi
Name:rpiAUniRule annotation
Ordered Locus Names:SMU_1234
OrganismiStreptococcus mutans serotype c (strain ATCC 700610 / UA159)
Taxonomic identifieri210007 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000002512 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001584731 – 225Ribose-5-phosphate isomerase AAdd BLAST225

Interactioni

Subunit structurei

Homodimer.UniRule annotation1 Publication

Protein-protein interaction databases

STRINGi210007.SMU_1234.

Structurei

Secondary structure

1225
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 13Combined sources11
Beta strandi21 – 24Combined sources4
Helixi30 – 44Combined sources15
Beta strandi49 – 54Combined sources6
Helixi55 – 64Combined sources10
Helixi71 – 73Combined sources3
Beta strandi77 – 82Combined sources6
Beta strandi85 – 87Combined sources3
Helixi101 – 109Combined sources9
Beta strandi111 – 119Combined sources9
Helixi120 – 122Combined sources3
Beta strandi125 – 127Combined sources3
Beta strandi132 – 136Combined sources5
Helixi141 – 150Combined sources10
Beta strandi155 – 157Combined sources3
Beta strandi172 – 176Combined sources5
Helixi184 – 192Combined sources9
Beta strandi197 – 203Combined sources7
Beta strandi208 – 214Combined sources7
Turni215 – 218Combined sources4
Beta strandi219 – 222Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3L7OX-ray1.70A/B1-225[»]
ProteinModelPortaliQ8DTT9.
SMRiQ8DTT9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8DTT9.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni26 – 29Substrate bindingUniRule annotation4
Regioni82 – 85Substrate bindingUniRule annotation4
Regioni95 – 98Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the ribose 5-phosphate isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E66. Bacteria.
COG0120. LUCA.
KOiK01807.
OMAiGACHVQE.
PhylomeDBiQ8DTT9.

Family and domain databases

CDDicd01398. RPI_A. 1 hit.
HAMAPiMF_00170. Rib_5P_isom_A. 1 hit.
InterProiIPR004788. Ribose5P_isomerase_typA.
IPR020672. Ribose5P_isomerase_typA_subgr.
[Graphical view]
PANTHERiPTHR11934. PTHR11934. 1 hit.
PfamiPF06026. Rib_5-P_isom_A. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00021. rpiA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8DTT9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEELKKIAGV RAAQYVEDGM IVGLGTGSTA YYFVEEVGRR VQEEGLQVIG
60 70 80 90 100
VTTSSRTTAQ AQALGIPLKS IDEVDSVDVT VDGADEVDPN FNGIKGGGGA
110 120 130 140 150
LLMEKIVGTL TKDYIWVVDE SKMVDTLGAF RLPVEVVQYG AERLFREFEK
160 170 180 190 200
KGYKPSFREY DGVRFVTDMK NFIIDLDLGS IPDPIAFGNM LDHQVGVVEH
210 220
GLFNGMVNRV IVAGKDGVRI LEANK
Length:225
Mass (Da):24,568
Last modified:March 1, 2003 - v1
Checksum:i06A854001BCE9D9B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014133 Genomic DNA. Translation: AAN58919.1.
RefSeqiNP_721613.1. NC_004350.2.
WP_002263209.1. NC_004350.2.

Genome annotation databases

EnsemblBacteriaiAAN58919; AAN58919; SMU_1234.
GeneIDi1028528.
KEGGismu:SMU_1234.
PATRICi19664555. VBIStrMut61772_1107.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014133 Genomic DNA. Translation: AAN58919.1.
RefSeqiNP_721613.1. NC_004350.2.
WP_002263209.1. NC_004350.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3L7OX-ray1.70A/B1-225[»]
ProteinModelPortaliQ8DTT9.
SMRiQ8DTT9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi210007.SMU_1234.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN58919; AAN58919; SMU_1234.
GeneIDi1028528.
KEGGismu:SMU_1234.
PATRICi19664555. VBIStrMut61772_1107.

Phylogenomic databases

eggNOGiENOG4105E66. Bacteria.
COG0120. LUCA.
KOiK01807.
OMAiGACHVQE.
PhylomeDBiQ8DTT9.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00412.
BRENDAi5.3.1.6. 5941.

Miscellaneous databases

EvolutionaryTraceiQ8DTT9.

Family and domain databases

CDDicd01398. RPI_A. 1 hit.
HAMAPiMF_00170. Rib_5P_isom_A. 1 hit.
InterProiIPR004788. Ribose5P_isomerase_typA.
IPR020672. Ribose5P_isomerase_typA_subgr.
[Graphical view]
PANTHERiPTHR11934. PTHR11934. 1 hit.
PfamiPF06026. Rib_5-P_isom_A. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00021. rpiA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRPIA_STRMU
AccessioniPrimary (citable) accession number: Q8DTT9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.