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Q8DTQ7

- HISX_STRMU

UniProt

Q8DTQ7 - HISX_STRMU

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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei127 – 1271NADUniRule annotation
Binding sitei187 – 1871NADUniRule annotation
Binding sitei210 – 2101NADUniRule annotation
Binding sitei233 – 2331SubstrateUniRule annotation
Metal bindingi255 – 2551ZincUniRule annotation
Binding sitei255 – 2551SubstrateUniRule annotation
Metal bindingi258 – 2581ZincUniRule annotation
Binding sitei258 – 2581SubstrateUniRule annotation
Active sitei323 – 3231Proton acceptorUniRule annotation
Active sitei324 – 3241Proton acceptorUniRule annotation
Binding sitei324 – 3241SubstrateUniRule annotation
Metal bindingi357 – 3571ZincUniRule annotation
Binding sitei357 – 3571SubstrateUniRule annotation
Binding sitei411 – 4111SubstrateUniRule annotation
Metal bindingi416 – 4161ZincUniRule annotation
Binding sitei416 – 4161SubstrateUniRule annotation

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciSMUT210007:GC7Z-1205-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:SMU_1270
OrganismiStreptococcus mutans serotype c (strain ATCC 700610 / UA159)
Taxonomic identifieri210007 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002512: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 427427Histidinol dehydrogenasePRO_0000135858Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi210007.SMU.1270.

Structurei

3D structure databases

ProteinModelPortaliQ8DTQ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0141.
KOiK00013.
OMAiICGPGNK.
OrthoDBiEOG6CVVCR.
PhylomeDBiQ8DTQ7.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8DTQ7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKRLTGTNEK ISNILYQEQL ELSKENLDVE ATVREIIEKV KEEGDEALRA
60 70 80 90 100
YSEKFDHVVL SELHVSDQVV NEAFDKIDKD VLTALENAKA NIESYHKQQL
110 120 130 140 150
KGGFEDQPSQ GVLRGQLIRP IERVGVYVPG GTAAYPSSVL MNVIPAKIAG
160 170 180 190 200
VKEIIMITPP QEHFVPAILV AAKLAGVDKI YQVGGAQGIA ALAYGTQTLP
210 220 230 240 250
KVDKITGPGN IFVATAKKLV YGVVGIDMIA GPSEIGVIAD STANPVYVAA
260 270 280 290 300
DLLSQAEHDV HARAILVTNS AELADAVELE IEKQLQTLPR QAIARPSIEN
310 320 330 340 350
NGRIIIAQDV ESMFELMNLV APEHLEIAID KAYDYLERVQ NAGSIFLGHY
360 370 380 390 400
TSEPIGDYYA GANHVLPTTA TSRFSSALGV HDFVKRIQYT QYSKAAVNAA
410 420
EKDITTLAYA EGLQAHARAI EVRNDKN
Length:427
Mass (Da):46,451
Last modified:March 1, 2003 - v1
Checksum:iF84C6A4E72E08EF2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014133 Genomic DNA. Translation: AAN58952.1.
RefSeqiNP_721646.1. NC_004350.2.

Genome annotation databases

EnsemblBacteriaiAAN58952; AAN58952; SMU_1270.
GeneIDi1028553.
KEGGismu:SMU_1270.
PATRICi19664619. VBIStrMut61772_1139.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014133 Genomic DNA. Translation: AAN58952.1 .
RefSeqi NP_721646.1. NC_004350.2.

3D structure databases

ProteinModelPortali Q8DTQ7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 210007.SMU.1270.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN58952 ; AAN58952 ; SMU_1270 .
GeneIDi 1028553.
KEGGi smu:SMU_1270.
PATRICi 19664619. VBIStrMut61772_1139.

Phylogenomic databases

eggNOGi COG0141.
KOi K00013.
OMAi ICGPGNK.
OrthoDBi EOG6CVVCR.
PhylomeDBi Q8DTQ7.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci SMUT210007:GC7Z-1205-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700610 / UA159.

Entry informationi

Entry nameiHISX_STRMU
AccessioniPrimary (citable) accession number: Q8DTQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: March 1, 2003
Last modified: October 1, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3