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Q8DT64

- Q8DT64_STRMU

UniProt

Q8DT64 - Q8DT64_STRMU

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Protein
Submitted name: Putative histidine kinase CovS VicK-like protein
Gene
covS, SMU_1516
Organism
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.SAAS annotations

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphorelay sensor kinase activity Source: InterPro

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

KinaseSAAS annotationsImported, Transferase

Keywords - Ligandi

ATP-bindingSAAS annotations, Nucleotide-binding

Enzyme and pathway databases

BioCyciSMUT210007:GC7Z-1422-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Putative histidine kinase CovS VicK-like proteinImported
Gene namesi
Name:covSImported
Ordered Locus Names:SMU_1516Imported
OrganismiStreptococcus mutans serotype c (strain ATCC 700610 / UA159)Imported
Taxonomic identifieri210007 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002512: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: InterPro
Complete GO annotation...

PTM / Processingi

Keywords - PTMi

PhosphoproteinSAAS annotations

Interactioni

Protein-protein interaction databases

STRINGi210007.SMU.1516.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4I5SX-ray3.30A/B1-450[»]
ProteinModelPortaliQ8DT64.

Family & Domainsi

Phylogenomic databases

KOiK07652.
OMAiRVDNASR.
OrthoDBiEOG6G4VQG.
PhylomeDBiQ8DT64.

Family and domain databases

Gene3Di1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR003661. EnvZ-like_dim/P.
IPR003594. HATPase_ATP-bd.
IPR001610. PAC.
IPR000014. PAS.
IPR013767. PAS_fold.
IPR004358. Sig_transdc_His_kin-like_C.
IPR005467. Sig_transdc_His_kinase_core.
IPR009082. Sig_transdc_His_kinase_dimeric.
[Graphical view]
PfamiPF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
PF00989. PAS. 1 hit.
[Graphical view]
PRINTSiPR00344. BCTRLSENSOR.
SMARTiSM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
SM00086. PAC. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view]
SUPFAMiSSF47384. SSF47384. 1 hit.
SSF55785. SSF55785. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEiPS50109. HIS_KIN. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8DT64-1 [UniParc]FASTAAdd to Basket

« Hide

MTNVFESSPL FLRILLAVLI ILLFFYFIFL NYREYKNNNQ VKQLNAKVRS    50
LITGHYTDKL KVEDNSDLSE LVNNVNDLSE VFRLTHENLA QEKNRLTSIL 100
SYMTDGVLAT DRSGKITVIN DMAQKQLNVT REQALECNIL DILDDDSYTY 150
NDLITKTPEI VLTRRDEYDE FITLRIRFAL NRRESGFISG LIAVLHDATE 200
QEKEERERRL FVSNVSHELR TPLTSVKSYL EALDDGALTE SVAPSFIKVS 250
LDETNRMMRM ITDLLSLSRI DNQTSHLDVE LTNFTAFMNY ILDRFDQIQS 300
QQSTNKVYEI IRDYPDKSVW IEIDTDKMTQ VIDNILNNAI KYSPDGGKVT 350
ITMQTTDTQL ILSISDQGLG IPKKDLPLIF DRFYRVDKAR SRAQGGTGLG 400
LAIAKEIVKQ HKGFIWANSE EGEGSTFTIV LPYENDNDAI DEWEEDEDES 450
Length:450
Mass (Da):51,697
Last modified:March 1, 2003 - v1
Checksum:i188D5D1199D5BF92
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014133 Genomic DNA. Translation: AAN59167.1.
RefSeqiNP_721861.1. NC_004350.2.

Genome annotation databases

EnsemblBacteriaiAAN59167; AAN59167; SMU_1516.
GeneIDi1028760.
KEGGismu:SMU_1516.
PATRICi19665041. VBIStrMut61772_1349.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014133 Genomic DNA. Translation: AAN59167.1 .
RefSeqi NP_721861.1. NC_004350.2.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4I5S X-ray 3.30 A/B 1-450 [» ]
ProteinModelPortali Q8DT64.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 210007.SMU.1516.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN59167 ; AAN59167 ; SMU_1516 .
GeneIDi 1028760.
KEGGi smu:SMU_1516.
PATRICi 19665041. VBIStrMut61772_1349.

Phylogenomic databases

KOi K07652.
OMAi RVDNASR.
OrthoDBi EOG6G4VQG.
PhylomeDBi Q8DT64.

Enzyme and pathway databases

BioCyci SMUT210007:GC7Z-1422-MONOMER.

Family and domain databases

Gene3Di 1.10.287.130. 1 hit.
3.30.565.10. 1 hit.
InterProi IPR003661. EnvZ-like_dim/P.
IPR003594. HATPase_ATP-bd.
IPR001610. PAC.
IPR000014. PAS.
IPR013767. PAS_fold.
IPR004358. Sig_transdc_His_kin-like_C.
IPR005467. Sig_transdc_His_kinase_core.
IPR009082. Sig_transdc_His_kinase_dimeric.
[Graphical view ]
Pfami PF02518. HATPase_c. 1 hit.
PF00512. HisKA. 1 hit.
PF00989. PAS. 1 hit.
[Graphical view ]
PRINTSi PR00344. BCTRLSENSOR.
SMARTi SM00387. HATPase_c. 1 hit.
SM00388. HisKA. 1 hit.
SM00086. PAC. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view ]
SUPFAMi SSF47384. SSF47384. 1 hit.
SSF55785. SSF55785. 1 hit.
SSF55874. SSF55874. 1 hit.
PROSITEi PS50109. HIS_KIN. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700610 / UA159.
  2. "Mechanistic insights revealed by the crystal structure of a histidine kinase with signal transducer and sensor domains."
    Wang C., Sang J., Wang J., Su M., Downey J.S., Wu Q., Wang S., Cai Y., Xu X., Wu J., Senadheera D.B., Cvitkovitch D.G., Chen L., Goodman S.D., Han A.
    PLoS Biol. 11:e1001493-e1001493(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.30 ANGSTROMS).

Entry informationi

Entry nameiQ8DT64_STRMU
AccessioniPrimary (citable) accession number: Q8DT64
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: June 11, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome

External Data

Dasty 3

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