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Q8DT64

- Q8DT64_STRMU

UniProt

Q8DT64 - Q8DT64_STRMU

Protein
Submitted name:

Putative histidine kinase CovS VicK-like protein

Gene

covS

Organism
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.SAAS annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphorelay sensor kinase activity Source: InterPro

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: InterPro

    Keywords - Molecular functioni

    KinaseSAAS annotationImported, Transferase

    Keywords - Ligandi

    ATP-bindingSAAS annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSMUT210007:GC7Z-1422-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Putative histidine kinase CovS VicK-like proteinImported
    Gene namesi
    Name:covSImported
    Ordered Locus Names:SMU_1516Imported
    OrganismiStreptococcus mutans serotype c (strain ATCC 700610 / UA159)Imported
    Taxonomic identifieri210007 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000002512: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. membrane Source: InterPro

    PTM / Processingi

    Keywords - PTMi

    PhosphoproteinSAAS annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi210007.SMU.1516.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4I5SX-ray3.30A/B1-450[»]
    ProteinModelPortaliQ8DT64.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    KOiK07652.
    OMAiRVDNASR.
    OrthoDBiEOG6G4VQG.
    PhylomeDBiQ8DT64.

    Family and domain databases

    Gene3Di1.10.287.130. 1 hit.
    3.30.565.10. 1 hit.
    InterProiIPR003661. EnvZ-like_dim/P.
    IPR003594. HATPase_ATP-bd.
    IPR001610. PAC.
    IPR000014. PAS.
    IPR013767. PAS_fold.
    IPR004358. Sig_transdc_His_kin-like_C.
    IPR005467. Sig_transdc_His_kinase_core.
    IPR009082. Sig_transdc_His_kinase_dimeric.
    [Graphical view]
    PfamiPF02518. HATPase_c. 1 hit.
    PF00512. HisKA. 1 hit.
    PF00989. PAS. 1 hit.
    [Graphical view]
    PRINTSiPR00344. BCTRLSENSOR.
    SMARTiSM00387. HATPase_c. 1 hit.
    SM00388. HisKA. 1 hit.
    SM00086. PAC. 1 hit.
    SM00091. PAS. 1 hit.
    [Graphical view]
    SUPFAMiSSF47384. SSF47384. 1 hit.
    SSF55785. SSF55785. 1 hit.
    SSF55874. SSF55874. 1 hit.
    PROSITEiPS50109. HIS_KIN. 1 hit.
    PS50112. PAS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8DT64-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTNVFESSPL FLRILLAVLI ILLFFYFIFL NYREYKNNNQ VKQLNAKVRS    50
    LITGHYTDKL KVEDNSDLSE LVNNVNDLSE VFRLTHENLA QEKNRLTSIL 100
    SYMTDGVLAT DRSGKITVIN DMAQKQLNVT REQALECNIL DILDDDSYTY 150
    NDLITKTPEI VLTRRDEYDE FITLRIRFAL NRRESGFISG LIAVLHDATE 200
    QEKEERERRL FVSNVSHELR TPLTSVKSYL EALDDGALTE SVAPSFIKVS 250
    LDETNRMMRM ITDLLSLSRI DNQTSHLDVE LTNFTAFMNY ILDRFDQIQS 300
    QQSTNKVYEI IRDYPDKSVW IEIDTDKMTQ VIDNILNNAI KYSPDGGKVT 350
    ITMQTTDTQL ILSISDQGLG IPKKDLPLIF DRFYRVDKAR SRAQGGTGLG 400
    LAIAKEIVKQ HKGFIWANSE EGEGSTFTIV LPYENDNDAI DEWEEDEDES 450
    Length:450
    Mass (Da):51,697
    Last modified:March 1, 2003 - v1
    Checksum:i188D5D1199D5BF92
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014133 Genomic DNA. Translation: AAN59167.1.
    RefSeqiNP_721861.1. NC_004350.2.

    Genome annotation databases

    EnsemblBacteriaiAAN59167; AAN59167; SMU_1516.
    GeneIDi1028760.
    KEGGismu:SMU_1516.
    PATRICi19665041. VBIStrMut61772_1349.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014133 Genomic DNA. Translation: AAN59167.1 .
    RefSeqi NP_721861.1. NC_004350.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4I5S X-ray 3.30 A/B 1-450 [» ]
    ProteinModelPortali Q8DT64.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 210007.SMU.1516.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN59167 ; AAN59167 ; SMU_1516 .
    GeneIDi 1028760.
    KEGGi smu:SMU_1516.
    PATRICi 19665041. VBIStrMut61772_1349.

    Phylogenomic databases

    KOi K07652.
    OMAi RVDNASR.
    OrthoDBi EOG6G4VQG.
    PhylomeDBi Q8DT64.

    Enzyme and pathway databases

    BioCyci SMUT210007:GC7Z-1422-MONOMER.

    Family and domain databases

    Gene3Di 1.10.287.130. 1 hit.
    3.30.565.10. 1 hit.
    InterProi IPR003661. EnvZ-like_dim/P.
    IPR003594. HATPase_ATP-bd.
    IPR001610. PAC.
    IPR000014. PAS.
    IPR013767. PAS_fold.
    IPR004358. Sig_transdc_His_kin-like_C.
    IPR005467. Sig_transdc_His_kinase_core.
    IPR009082. Sig_transdc_His_kinase_dimeric.
    [Graphical view ]
    Pfami PF02518. HATPase_c. 1 hit.
    PF00512. HisKA. 1 hit.
    PF00989. PAS. 1 hit.
    [Graphical view ]
    PRINTSi PR00344. BCTRLSENSOR.
    SMARTi SM00387. HATPase_c. 1 hit.
    SM00388. HisKA. 1 hit.
    SM00086. PAC. 1 hit.
    SM00091. PAS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47384. SSF47384. 1 hit.
    SSF55785. SSF55785. 1 hit.
    SSF55874. SSF55874. 1 hit.
    PROSITEi PS50109. HIS_KIN. 1 hit.
    PS50112. PAS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700610 / UA159Imported.
    2. "Mechanistic insights revealed by the crystal structure of a histidine kinase with signal transducer and sensor domains."
      Wang C., Sang J., Wang J., Su M., Downey J.S., Wu Q., Wang S., Cai Y., Xu X., Wu J., Senadheera D.B., Cvitkovitch D.G., Chen L., Goodman S.D., Han A.
      PLoS Biol. 11:e1001493-e1001493(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.30 ANGSTROMS).

    Entry informationi

    Entry nameiQ8DT64_STRMU
    AccessioniPrimary (citable) accession number: Q8DT64
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 1, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3