Reviewed, UniProtKB/Swiss-Prot Q8DT57 (MURA1_STRMU)

Names and origin

Protein names

Recommended name:
    UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1
    EC=2.5.1.7
Alternative name(s):
    Enoylpyruvate transferase 1
    UDP-N-acetylglucosamine enolpyruvyl transferase 1
      Short name=EPT 1

Gene names

Name:	murA1
Ordered Locus Names:	SMU_1525

Organism

Streptococcus mutans [Complete proteome] [HAMAP]

Taxonomic identifier

1309 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	423 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine By similarity.
Catalytic activity	Phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine. HAMAP MF_00111
Pathway	Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00111
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the EPSP synthase family. MurA subfamily.

Ontologies

Keywords
Biological process	Cell cycle Cell division Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	UDP-N-acetylgalactosamine biosynthetic process Inferred from electronic annotation. Source: InterPro cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: HAMAP regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 423	423	UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1 HAMAP MF_00111		PRO_0000231278
Sites
	Active site	120	1	Proton donor By similarity
	Binding site	120	1	Phosphoenolpyruvate (covalent) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8DT57-1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: CAD40B6A09D0C017	FASTA	423	45,617
	10 20 30 40 50 60 MDRIIIEGGN TQLKGEVVIE GAKNAVLPLL AAAILPTEGQ TLLKNVPILS DVFTMNNVVR 70 80 90 100 110 120 GLNVAVDFDE ERNQILVDAT GDILDVAPYE YVSQMRASIV VLGPILARNG HAKVSMPGGC 130 140 150 160 170 180 TIGSRPIDLH LKGLEAMGAK IQQTGGDITA TADRLKGANI YMDFPSVGAT QNLMMAATLA 190 200 210 220 230 240 DGTTIIENAA REPEIVDLAN LLNKMGARVI GAGTETLTII GVDKMHGTDH SVVQDRIEAG 250 260 270 280 290 300 TFMVAAAMTN GNVLVKNAVW EHNRPLISKL REMGVQVTEE ERGIRVISDV TKLRPVTVKT 310 320 330 340 350 360 MPHPGFPTDM QAQFTALMAV VKGESTMIET VFENRFQHLE EMRRMGLTSE ILRDTAMIHG 370 380 390 400 410 420 GEQLQGAQVM STDLRASAAL ILTGMVADGK TTVGKLNHLD RGYYQFHEKL TKLGATISRV NGE

References

[1]

"Genome sequence of Streptococcus mutans UA159, a cariogenic dental pathogen." Ajdic D.J., McShan W.M., McLaughlin R.E., Savic G., Chang J., Carson M.B., Primeaux C., Tian R., Kenton S., Jia H.G., Lin S.P., Qian Y., Li S., Zhu H., Najar F.Z., Lai H., White J., Roe B.A., Ferretti J.J. Proc. Natl. Acad. Sci. U.S.A. 99:14434-14439(2002) [PubMed: 12397186] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700610 / UA159 / Serotype c.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE014133 Genomic DNA. Translation: AAN59175.1.
RefSeq	NP_721869.1.
3D structure databases
HSSP	HSSP built from PDB template 1DLG based on UniProtKB P33038.
ModBase	Search...
Genome annotation databases
GeneID	1028764.
GenomeReviews	Gene locus SMU_1525 in contig AE014133_GR.
KEGG	smu:SMU.1525.
NMPDR	fig|210007.1.peg.1382.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8DT57.
OMA	VSRVYHL.
Enzyme and pathway databases
BioCyc	SMUT210007:SMU_1525-MON.
BRENDA	2.5.1.7. 20716.
Family and domain databases
HAMAP	MF_00111. [Tree]
InterPro	IPR001986. EPSP_synthase_core. IPR005750. UDP_GlcNAc_COvinyl_MurA. [Graphical view]
Gene3D	G3DSA:3.65.10.10. EPSP_synthase. 2 hits.
PANTHER	PTHR21090:SF4. AcGlu_Tran_MurA. 1 hit.
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
ProDom	PD001867. EPSP_synth. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01072. murA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MURA1_STRMU

Accession

Primary (citable) accession number: Q8DT57

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	March 1, 2003
Last modified:	November 3, 2009
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)