Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8DT52 (GLGB_STRMU) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
1,4-alpha-glucan branching enzyme GlgB

EC=2.4.1.18
Alternative name(s):
1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase
Alpha-(1->4)-glucan branching enzyme
Glycogen branching enzyme
Short name=BE
Gene names
Name:glgB
Ordered Locus Names:SMU_1539
OrganismStreptococcus mutans serotype c (strain ATCC 700610 / UA159) [Complete proteome] [HAMAP]
Taxonomic identifier210007 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length628 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position By similarity. HAMAP-Rule MF_00685

Catalytic activity

Transfers a segment of a (1->4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain. HAMAP-Rule MF_00685

Pathway

Glycan biosynthesis; glycogen biosynthesis. HAMAP-Rule MF_00685

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00685

Sequence similarities

Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 6286281,4-alpha-glucan branching enzyme GlgB HAMAP-Rule MF_00685
PRO_0000188751

Sites

Active site3041Nucleophile By similarity
Active site3551Proton donor By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8DT52 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 795A2B117F5461F6

FASTA62873,968
        10         20         30         40         50         60 
MNEREALRTF GTGENFHAQH YFGFHETEKN GVKGYIFRVW APNAEDLHLI GDFTGWFDNP 

        70         80         90        100        110        120 
LQMDKNEAGV WEVFTDLPKE GHIYKYLVKR QGGQIVEKMD PFAIYLEERP GTGSLIRTIP 

       130        140        150        160        170        180 
EKKWKDGLWL GRRKRWGFFK RPVNIYEVHA GSWKQNEDGS PYSFEQLKDE LVPYLVKMNY 

       190        200        210        220        230        240 
THVEFMPLMA HPLGMSWGYQ LMGFFAFEHT YGTPEQFQDF VEACHLNNIG VIVDWVPGHF 

       250        260        270        280        290        300 
TQNDDALAYF DGTPTFEYQD HDRAHNYRWG ALNFDLGKNQ VQSFLISSAK FWIDFYHIDG 

       310        320        330        340        350        360 
IRVDAVSNML YLDYDEGPWQ PNIEGNNRNL EGYYFLQRLN TVLKLAHPDV MMIAEESTAT 

       370        380        390        400        410        420 
TKITGRREEG GLGFDYKWNM GWMNDILKFY EEDPIYRKYD FNLVTFSFMY LFSENFILPF 

       430        440        450        460        470        480 
SHDEVVHGKK SLMHKMWGDR YNQFAGLRNL YTYQICHPGK KLLFMGSEFG QFLEWKYDHA 

       490        500        510        520        530        540 
LEWTNLEEED GLNLKMQDFT SQLNQFYKDH KVLWQLDTSY DGLEIIDADN VDESVLSFIR 

       550        560        570        580        590        600 
KNEKGDLLVC VFNMVPVERK GFTIGVPVAG IYEEVWNTEL EEFGGVWKEH NMTVKTQKNL 

       610        620 
WKEYENTLSF TLPALGASIW KIKRRLRK 

« Hide

References

[1]"Genome sequence of Streptococcus mutans UA159, a cariogenic dental pathogen."
Ajdic D.J., McShan W.M., McLaughlin R.E., Savic G., Chang J., Carson M.B., Primeaux C., Tian R., Kenton S., Jia H.G., Lin S.P., Qian Y., Li S., Zhu H., Najar F.Z., Lai H., White J., Roe B.A., Ferretti J.J.
Proc. Natl. Acad. Sci. U.S.A. 99:14434-14439(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700610 / UA159.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE014133 Genomic DNA. Translation: AAN59189.1.
RefSeqNP_721883.1. NC_004350.2.

3D structure databases

ProteinModelPortalQ8DT52.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING210007.SMU.1539.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAN59189; AAN59189; SMU_1539.
GeneID1028781.
KEGGsmu:SMU_1539.
PATRIC19665085. VBIStrMut61772_1371.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0296.
KOK00700.
OMAPIGVAYK.
OrthoDBEOG6JX7GT.
PhylomeDBQ8DT52.

Enzyme and pathway databases

BioCycSMUT210007:GC7Z-1444-MONOMER.
UniPathwayUPA00164.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
2.60.40.1180. 1 hit.
3.20.20.80. 1 hit.
HAMAPMF_00685. GlgB.
InterProIPR006048. A-amylase_b_C.
IPR006407. GlgB.
IPR015902. Glyco_hydro_13.
IPR013780. Glyco_hydro_13_b.
IPR006047. Glyco_hydro_13_cat_dom.
IPR004193. Glyco_hydro_13_N.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
[Graphical view]
PANTHERPTHR10357. PTHR10357. 1 hit.
PfamPF00128. Alpha-amylase. 1 hit.
PF02806. Alpha-amylase_C. 1 hit.
PF02922. CBM_48. 1 hit.
[Graphical view]
PIRSFPIRSF000463. GlgB. 1 hit.
SUPFAMSSF51445. SSF51445. 1 hit.
SSF81296. SSF81296. 1 hit.
TIGRFAMsTIGR01515. branching_enzym. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGLGB_STRMU
AccessionPrimary (citable) accession number: Q8DT52
Entry history
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries