Reviewed, UniProtKB/Swiss-Prot Q8DT24 (MURA2_STRMU)

Names and origin

Protein names

Recommended name:
    UDP-N-acetylglucosamine 1-carboxyvinyltransferase 2
    EC=2.5.1.7
Alternative name(s):
    Enoylpyruvate transferase 2
    UDP-N-acetylglucosamine enolpyruvyl transferase 2
      Short name=EPT 2

Gene names

Name:	murA2
Synonyms:	murZ
Ordered Locus Names:	SMU_1572

Organism

Streptococcus mutans [Complete proteome] [HAMAP]

Taxonomic identifier

1309 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	419 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine By similarity.
Catalytic activity	Phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine. HAMAP MF_00111
Pathway	Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00111
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the EPSP synthase family. MurA subfamily.

Ontologies

Keywords
Biological process	Cell cycle Cell division Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	UDP-N-acetylgalactosamine biosynthetic process Inferred from electronic annotation. Source: InterPro cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: HAMAP regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 419	419	UDP-N-acetylglucosamine 1-carboxyvinyltransferase 2 HAMAP MF_00111		PRO_0000231277
Sites
	Active site	116	1	Proton donor By similarity
	Binding site	116	1	Phosphoenolpyruvate (covalent) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8DT24-1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 39079F8A7A2F53CC	FASTA	419	44,716
	10 20 30 40 50 60 MRKIVINGGK PLKGEVAVSG AKNSVVALIP AIILADDIVT LDGVPAISDV DSLIDIMTLM 70 80 90 100 110 120 GASVECDGDS LKIDPRGVKD IPMPYGKINS LRASYYFYSS LLGRFGRAVV GLPGGCDLGP 130 140 150 160 170 180 RPIDLHLKAF KAMGATVSYE GEAMRLSTEG KPLKGAHIYM DTVSVGATIN TMIAASKAQG 190 200 210 220 230 240 RTVIENAARE PEIIDIATLL NNMGAHIRGA GTDMIIIEGV EKLHGTRHQV IPDRIEAGSY 250 260 270 280 290 300 IALAAAVGEG IKVTNVLYEH LESFISKLEE MGVRMTIEED SVFVEKQDKL KAVSIKTSPY 310 320 330 340 350 360 PGFATDLQQP ITPLLLTAVG RGKIRDTIYE KRVNHVAELA RMGAKISVLG GQIIYEGPNE 370 380 390 400 410 LSGAPVKATD LRAGAALVTA GLMAKGQTVI TNIEFILRGY SDIIQKLNRL GADIEIVEE

References

[1]

"Genome sequence of Streptococcus mutans UA159, a cariogenic dental pathogen." Ajdic D.J., McShan W.M., McLaughlin R.E., Savic G., Chang J., Carson M.B., Primeaux C., Tian R., Kenton S., Jia H.G., Lin S.P., Qian Y., Li S., Zhu H., Najar F.Z., Lai H., White J., Roe B.A., Ferretti J.J. Proc. Natl. Acad. Sci. U.S.A. 99:14434-14439(2002) [PubMed: 12397186] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700610 / UA159 / Serotype c.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE014133 Genomic DNA. Translation: AAN59217.1.
RefSeq	NP_721911.1.
3D structure databases
HSSP	HSSP built from PDB template 1DLG based on UniProtKB P33038.
ModBase	Search...
Genome annotation databases
GeneID	1028804.
GenomeReviews	Gene locus SMU_1572 in contig AE014133_GR.
KEGG	smu:SMU.1572.
NMPDR	fig|210007.1.peg.1424.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8DT24.
OMA	LESFICK.
Enzyme and pathway databases
BioCyc	SMUT210007:SMU_1572-MON.
BRENDA	2.5.1.7. 20716.
Family and domain databases
HAMAP	MF_00111. [Tree]
InterPro	IPR001986. EPSP_synthase_core. IPR005750. UDP_GlcNAc_COvinyl_MurA. [Graphical view]
Gene3D	G3DSA:3.65.10.10. EPSP_synthase. 1 hit.
PANTHER	PTHR21090:SF4. AcGlu_Tran_MurA. 1 hit.
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
ProDom	PD001867. EPSP_synth. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01072. murA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MURA2_STRMU

Accession

Primary (citable) accession number: Q8DT24

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	March 1, 2003
Last modified:	November 3, 2009
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)