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Protein

Thymidylate kinase

Gene

tmk

Organism
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.UniRule annotation

Catalytic activityi

ATP + dTMP = ADP + dTDP.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 188ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Nucleotide biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSMUT210007:GC7Z-1557-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidylate kinaseUniRule annotation (EC:2.7.4.9UniRule annotation)
Alternative name(s):
dTMP kinaseUniRule annotation
Gene namesi
Name:tmkUniRule annotation
Synonyms:kthY
Ordered Locus Names:SMU_1663
OrganismiStreptococcus mutans serotype c (strain ATCC 700610 / UA159)
Taxonomic identifieri210007 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000002512 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 212212Thymidylate kinasePRO_0000155348Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi210007.SMU_1663.

Structurei

3D structure databases

ProteinModelPortaliQ8DSU6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidylate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108ZMD. Bacteria.
COG0125. LUCA.
KOiK00943.
OMAiGGIDIAE.
OrthoDBiEOG64JFSH.
PhylomeDBiQ8DSU6.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00165. Thymidylate_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR018095. Thymidylate_kin_CS.
IPR018094. Thymidylate_kinase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00041. DTMP_kinase. 1 hit.
PROSITEiPS01331. THYMIDYLATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8DSU6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKGIFISFE GPDGAGKTTV LEAILPQLKK LVAKEVITTR EPGGVAIAES
60 70 80 90 100
IRDLILDVNH TNMDDKTELL LYIAARRQHL VERILPELKK GNLVLVDRFI
110 120 130 140 150
DSSVAYQGYG RGLDADAVTW LNNFATDGLQ PDLTLYFDVD SQIGLTRIEK
160 170 180 190 200
NKEREVNRLD LEQLDMHRRV RSGYLKLAQE NPDRIVTIDA ARPLEEVITD
210
ALFIIKQRCL EK
Length:212
Mass (Da):23,956
Last modified:March 1, 2003 - v1
Checksum:iBDB723BA727411CF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014133 Genomic DNA. Translation: AAN59302.1.
RefSeqiNP_721996.1. NC_004350.2.
WP_002262681.1. NC_004350.2.

Genome annotation databases

EnsemblBacteriaiAAN59302; AAN59302; SMU_1663.
GeneIDi1028897.
KEGGismu:SMU_1663.
PATRICi19665313. VBIStrMut61772_1485.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014133 Genomic DNA. Translation: AAN59302.1.
RefSeqiNP_721996.1. NC_004350.2.
WP_002262681.1. NC_004350.2.

3D structure databases

ProteinModelPortaliQ8DSU6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi210007.SMU_1663.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN59302; AAN59302; SMU_1663.
GeneIDi1028897.
KEGGismu:SMU_1663.
PATRICi19665313. VBIStrMut61772_1485.

Phylogenomic databases

eggNOGiENOG4108ZMD. Bacteria.
COG0125. LUCA.
KOiK00943.
OMAiGGIDIAE.
OrthoDBiEOG64JFSH.
PhylomeDBiQ8DSU6.

Enzyme and pathway databases

BioCyciSMUT210007:GC7Z-1557-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00165. Thymidylate_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR018095. Thymidylate_kin_CS.
IPR018094. Thymidylate_kinase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00041. DTMP_kinase. 1 hit.
PROSITEiPS01331. THYMIDYLATE_KINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700610 / UA159.

Entry informationi

Entry nameiKTHY_STRMU
AccessioniPrimary (citable) accession number: Q8DSU6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: March 1, 2003
Last modified: November 11, 2015
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.