Q8DSG3 (SYD1_STRMU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartyl-tRNA synthetase 1
EC=6.1.1.12

Alternative name(s):
Aspartate--tRNA ligase 1
Short name=AspRS 1

Gene names

Name:	aspS1
Ordered Locus Names:	SMU_1822

Organism

Streptococcus mutans [Complete proteome] [HAMAP]

Taxonomic identifier

1309 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	583 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp). HAMAP MF_00044_B
Subunit structure	Homodimer By similarity. HAMAP MF_00044_B
Subcellular location	Cytoplasm HAMAP MF_00044_B.
Sequence similarities	Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aspartyl-tRNA aminoacylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW aspartate-tRNA ligase activity Inferred from electronic annotation. Source: EC nucleic acid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 583	583	Aspartyl-tRNA synthetase 1 HAMAP MF_00044_B		PRO_0000110953

Sequences

	Sequence		Length	Mass (Da)
	Q8DSG3-1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: C54974E7690F315C	FASTA	583	66,163
	10 20 30 40 50 60 MKELFIGNYG LEQVGQKVTA KGWVANIRNH GKLAFIELRD REGLLQVFVD SAVADFDKLH 70 80 90 100 110 120 DLHKESILAV TGEIVARDER FVNPHIKSGQ VELRAETIEI IASSKLLPFE LDNHAHAGED 130 140 150 160 170 180 IRQKYRYLDL RREKMTANLK LRHQVTKAIR DYLNQADFID VETPYLTKST PEGARDFLVP 190 200 210 220 230 240 SRVFKNQFYA LPQSPQMLKQ LLMGAGLERY YQIVRCFRDE DLRGDRQPEF TQVDLEMSFV 250 260 270 280 290 300 SEEDVRNLVE GMLKAVVKAS KGIELTEAFP IISYAQAMRR FGSDKPDTRF AMELKDLTEL 310 320 330 340 350 360 SRGNTSLFLQ KGLKKENGVV MGICAKNAAK AFTNRQMATL KQLVMDFGVA GFATATIEKG 370 380 390 400 410 420 QVTGSLKSTF KDHNTELLEL FEAEDGDMIF FVTGSLKRVQ EALGGLRVRL AKDLELIDND 430 440 450 460 470 480 KLNFLWVVDW PLLEWNEDLN RYQAMHHPFT QGAFEDGSDW KENPEKMMSR AYDIVLNGYE 490 500 510 520 530 540 IGGGSLRIHK RSAQEAMFEL LGMKKEDYER DFGFFLEALE YGFPPHGGLA LGLDRLVMIL 550 560 570 580 AEEGNIREVI AFPKNGQGAD AMLESPSLVA DQQLAELRLA LRD

References

[1]

"Genome sequence of Streptococcus mutans UA159, a cariogenic dental pathogen." Ajdic D.J., McShan W.M., McLaughlin R.E., Savic G., Chang J., Carson M.B., Primeaux C., Tian R., Kenton S., Jia H.G., Lin S.P., Qian Y., Li S., Zhu H., Najar F.Z., Lai H., White J., Roe B.A., Ferretti J.J. Proc. Natl. Acad. Sci. U.S.A. 99:14434-14439(2002) [PubMed: 12397186] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700610 / UA159 / Serotype c.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014133 Genomic DNA. Translation: AAN59447.1.
RefSeq	NP_722141.1.
3D structure databases
ProteinModelPortal	Q8DSG3.
SMR	Q8DSG3. Positions 3-582.
ModBase	Search...
Genome annotation databases
EnsemblBacteria	EBSTRT00000013752; EBSTRP00000013234; EBSTRG00000013752.
GeneID	1029036.
GenomeReviews	Gene locus SMU_1822 in contig AE014133_GR.
KEGG	smu:SMU.1822.
NMPDR	fig|210007.1.peg.1654.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG396032.
OMA	VANIRNH.
ProtClustDB	PRK00476.
Enzyme and pathway databases
BioCyc	SMUT210007:SMU_1822-MONOMER.
BRENDA	6.1.1.12. 20716.
Family and domain databases
HAMAP	MF_00044_B. Asp_tRNA_synth_B. [Tree]
InterPro	IPR004364. aa-tRNA-synt_II. IPR018150. aa-tRNA-synt_II-like. IPR006195. aa-tRNA-synth_II_cons-dom. IPR020564. Asp-tRNA-synth_IIb_bac-type. IPR004524. Asp-tRNA-synth_IIb_bac/mt. IPR018153. Asp-tRNA-synth_IIb_C_bac/mt. IPR002312. Asp/Asn-tRNA-synth_IIb. IPR004115. GAD_dom. IPR012340. NA-bd_OB-fold. IPR016027. NA-bd_OB-fold-like. IPR004365. NA-bd_OB_tRNA-helicase. [Graphical view]
Gene3D	G3DSA:2.40.50.140. OB_NA_bd_sub. 1 hit.
PANTHER	PTHR22594. aa-tRNA-synt_II. 1 hit. PTHR22594:SF5. AspS_bac. 1 hit.
Pfam	PF02938. GAD. 1 hit. PF00152. tRNA-synt_2. 1 hit. PF01336. tRNA_anti. 1 hit. [Graphical view]
PRINTS	PR01042. TRNASYNTHASP.
SUPFAM	SSF50249. Nucleic_acid_OB. 1 hit.
TIGRFAMs	TIGR00459. aspS_bact. 1 hit.
PROSITE	PS50862. AA_TRNA_LIGASE_II. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYD1_STRMU

Accession

Primary (citable) accession number: Q8DSG3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2004
Last sequence update:	March 1, 2003
Last modified:	August 10, 2010
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)