Q8DSF2 (Q8DSF2_STRMU) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Phospho-2-dehydro-3-deoxyheptonate aldolase PIRNR PIRNR001361
EC=2.5.1.54 PIRNR PIRNR001361

Alternative name(s):
3-deoxy-D-arabino-heptulosonate 7-phosphate synthase PIRNR PIRNR001361
DAHP synthase PIRNR PIRNR001361
Phospho-2-keto-3-deoxyheptonate aldolase PIRNR PIRNR001361

Gene names

Name:	aroG EMBL AAN59459.1
Ordered Locus Names:	SMU_1836

Organism

Streptococcus mutans [Complete proteome] [HAMAP]

Taxonomic identifier

1309 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	344 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) By similarity. PIRNR PIRNR001361
Catalytic activity	Phosphoenolpyruvate + D-erythrose 4-phosphate + H2O = 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate. PIRNR PIRNR001361
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7. PIRNR PIRNR001361
Sequence similarities	Belongs to the class-I DAHP synthase family. PIRNR PIRNR001361

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis PIRNR PIRNR001361
Molecular function	Transferase PIRNR PIRNR001361 EMBL AAN59459.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3-deoxy-7-phosphoheptulonate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8DSF2 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 0BFCD7EDDD0E84CC	FASTA	344	39,096
	10 20 30 40 50 60 MGIHQKSKTI DLFTVKQGTQ LKGQDLAKKE ARDRELVSII KGEDNRLLLI IGPCSSDNEE 70 80 90 100 110 120 AVLEYAKRLA KLQEEVKDRI FMVMRVYTAK PRTNGDGYKG LIHQPNTSKL PDLINGIHAV 130 140 150 160 170 180 RNLHYRVITE TGLTTADEML YPSNLVLVDD LVSYHAVGAR SVEDQEHRFV ASGIDVPTGM 190 200 210 220 230 240 KNPTSGNLKV MLNALHAAQN SQNFIYNGAE VETDGNSLAH VILRGGSNEH GDYEPNYYYD 250 260 270 280 290 300 VLLKLIQQYE NMNLINPFIV VDTNHDNSGK NYLEQVRIVR QTLINRDWND KINKYVRGFM 310 320 330 340 IESYLEDGRQ DKPEVFGKSI TDPCLGWENT QQLIYEIYHT LKAK

References

[1]

"Genome sequence of Streptococcus mutans UA159, a cariogenic dental pathogen." Ajdic D.J., McShan W.M., McLaughlin R.E., Savic G., Chang J., Carson M.B., Primeaux C., Tian R., Kenton S., Jia H.G., Lin S.P., Qian Y., Li S., Zhu H., Najar F.Z., Lai H., White J., Roe B.A., Ferretti J.J. Proc. Natl. Acad. Sci. U.S.A. 99:14434-14439(2002) [PubMed: 12397186] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700610 / UA159 / Serotype c.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014133 Genomic DNA. Translation: AAN59459.1.
RefSeq	NP_722153.1. NC_004350.2.
3D structure databases
HSSP	HSSP built from PDB template 1GG1 based on UniProtKB P00886.
ProteinModelPortal	Q8DSF2.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTRT00000013465; EBSTRP00000012947; EBSTRG00000013465.
GeneID	1029050.
GenomeReviews	Gene locus SMU_1836 in contig AE014133_GR.
KEGG	smu:SMU_1836.
NMPDR	fig|210007.1.peg.1666.
PATRIC	19665669. VBIStrMut61772_1639.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000028141.
HOGENOM	HBG670536.
OMA	MDNSFKL.
ProtClustDB	PRK12755.
Enzyme and pathway databases
BioCyc	SMUT210007:SMU_1836-MONOMER.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR006218. DAHP1/KDSA. IPR006219. DHAP_synth_1. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01626.
PANTHER	PTHR21225. AroFGH. 1 hit.
Pfam	PF00793. DAHP_synth_1. 1 hit. [Graphical view]
PIRSF	PIRSF001361. DAHP_synthase. 1 hit.
TIGRFAMs	TIGR00034. AroFGH. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q8DSF2_STRMU

Accession

Primary (citable) accession number: Q8DSF2

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2003
Last sequence update:	March 1, 2003
Last modified:	January 25, 2012
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)