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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei613ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:SMU_1943
OrganismiStreptococcus mutans serotype c (strain ATCC 700610 / UA159)
Taxonomic identifieri210007 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000002512 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001520941 – 833Leucine--tRNA ligaseAdd BLAST833

Interactioni

Protein-protein interaction databases

STRINGi210007.SMU_1943.

Structurei

3D structure databases

ProteinModelPortaliQ8DS85.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi41 – 52"HIGH" regionAdd BLAST12
Motifi610 – 614"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T. Bacteria.
COG0495. LUCA.
KOiK01869.
OMAiHRFIKRL.
PhylomeDBiQ8DS85.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B. 1 hit.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_Ia_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 5 hits.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8DS85-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVYYNHKAIE NKWQKFWEDN HTFKTGTASS KPKFYALDMF PYPSGAGLHV
60 70 80 90 100
GHPEGYTATD ILSRFKRAQG YNVLHPMGWD AFGLPAEQYA MDTGHDPADF
110 120 130 140 150
TAQNIATFKR QIKSLGFSYD WDREINTTDP NYYKWTQWIF TKLYEKGLAY
160 170 180 190 200
EAEVPVNWVE ELGTAIANEE VLPDGTSERG GYPVVRKPMR QWMLKITAYA
210 220 230 240 250
ERLLEDLEDL DWPESIKDMQ RNWIGKSTGA NVTFKVKDTD EEFTVFTTRP
260 270 280 290 300
DTLFGATYAV LAPEHDLVDI ITTAGQAQAV ADYKHQASLK SDLARTDLAK
310 320 330 340 350
EKTGVWTGAY AINPVNGKEI PIWIADYVLA SYGTGAIMAV PAHDERDWEF
360 370 380 390 400
AKQFNLDIIP VLEGGNVAEA AYTDDGLHIN SGFLNGLDKA AAIDKMVTWL
410 420 430 440 450
ETEGVGNKKV TYRLRDWLFS RQRYWGEPIP IIHWEDGTST ALPENELPLV
460 470 480 490 500
LPVTKDIKPS GTGESPLANL TDWLEVTRED GVKGRRETNT MPQWAGSSWY
510 520 530 540 550
FLRYIDPHND QKLADEDLLK QWLPVDVYVG GAEHAVLHLL YARFWHKFLY
560 570 580 590 600
DLGVVPTKEP FQKLFNQGMI LGTSYRDHRG ALVATDKVEK RDGSFFNIET
610 620 630 640 650
DEELEQAPAK MSKSLKNVVN PDDVVEQYGA DTLRVYEMFM GPLDASIAWS
660 670 680 690 700
EEGLEGSRKF LDRVYRLITT KEIAAKNNGH LDKVYNEVVK TVTEHLEAMR
710 720 730 740 750
FNTAISQLMI FVNAANKEEQ LFLDYAKGFI QLLAPFAPHL AEELWQFLTQ
760 770 780 790 800
SGQSITYVAW PSYDESKLVE DEIEIVLQIK GKVRAKVVVS KDSSREDLEK
810 820 830
IALANDKIQA EVAGKDIVKV IAVPNKLVNI VIK
Length:833
Mass (Da):94,410
Last modified:March 1, 2003 - v1
Checksum:i257411C9E4D114C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014133 Genomic DNA. Translation: AAN59553.1.
RefSeqiNP_722247.1. NC_004350.2.
WP_002263843.1. NC_004350.2.

Genome annotation databases

EnsemblBacteriaiAAN59553; AAN59553; SMU_1943.
GeneIDi1029140.
KEGGismu:SMU_1943.
PATRICi19665847. VBIStrMut61772_1728.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014133 Genomic DNA. Translation: AAN59553.1.
RefSeqiNP_722247.1. NC_004350.2.
WP_002263843.1. NC_004350.2.

3D structure databases

ProteinModelPortaliQ8DS85.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi210007.SMU_1943.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN59553; AAN59553; SMU_1943.
GeneIDi1029140.
KEGGismu:SMU_1943.
PATRICi19665847. VBIStrMut61772_1728.

Phylogenomic databases

eggNOGiENOG4105C8T. Bacteria.
COG0495. LUCA.
KOiK01869.
OMAiHRFIKRL.
PhylomeDBiQ8DS85.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B. 1 hit.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_Ia_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 5 hits.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYL_STRMU
AccessioniPrimary (citable) accession number: Q8DS85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: March 1, 2003
Last modified: November 2, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.