Reviewed, UniProtKB/Swiss-Prot Q8DRV9 (SYD2_STRMU)

Names and origin

Protein names

Recommended name:
    Aspartyl-tRNA synthetase 2
    EC=6.1.1.12
Alternative name(s):
    Aspartate--tRNA ligase 2
      Short name=AspRS 2

Gene names

Name:	aspS2
Ordered Locus Names:	SMU_2101

Organism

Streptococcus mutans [Complete proteome] [HAMAP]

Taxonomic identifier

1309 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	589 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp). HAMAP MF_00044
Subunit structure	Homodimer By similarity. HAMAP MF_00044
Subcellular location	Cytoplasm HAMAP MF_00044.
Sequence similarities	Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aspartyl-tRNA aminoacylation Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP aspartate-tRNA ligase activity Inferred from electronic annotation. Source: HAMAP nucleic acid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 589	589	Aspartyl-tRNA synthetase 2 HAMAP MF_00044		PRO_0000110954

Sequences

	Sequence		Length	Mass (Da)
	Q8DRV9-1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 0EDDDC6426881A4A	FASTA	589	66,967
	10 20 30 40 50 60 MKRSMYAGAV RSEHIGQELT LKGWVARRRD LGGLIFIDLR DREGIVQLVI NPKTASNTVV 70 80 90 100 110 120 KSAESLRSEY VIEVTGMIVE RDQANDNLPT GCVEMQVTQL TILNASQTPP FEIKDKIEAN 130 140 150 160 170 180 DDTRLRYRYL DLRRPEMLKN FKLRAKVTHV IRNYLDDLDF IDVETPMLAK STPEGARDYL 190 200 210 220 230 240 VPSRMSRGHF YALPQSPQIT KQLLMNAGFD RYYQIVKCFR DEDLRGDRQP EFTQVDLETS 250 260 270 280 290 300 FLSEQEIQEI TERLIACVMK EVKGIELQLP LPQISYDTAM NNYGSDKPDT RFEMTLQDLT 310 320 330 340 350 360 DLVKNIDFKV FSQAPAVKAI VAKNAANSYS RKAIDKLTDI VKPFGAKGLA WVKYNDGKIG 370 380 390 400 410 420 GPIAKFLTTI EDELIERLQL EANDLVFFVA DDLEIANGSL GALRNHLAKE LNLIDHSKFN 430 440 450 460 470 480 FLWVVDWPMF EWSEEENRYT SAHHPFTLPQ EDTVAELEGD LSKVRAVAYD IVLNGYELGG 490 500 510 520 530 540 GSLRINQRET QERMFKALGF TKESAQKQFG FLLEAMDYGF PPHGGLALGL DRFVMLLAGK 550 560 570 580 ENIREVIAFP KNNKASDPMT QAPSLVSDKQ LDELYLQVNK NAVKNNEQE

References

[1]

"Genome sequence of Streptococcus mutans UA159, a cariogenic dental pathogen." Ajdic D.J., McShan W.M., McLaughlin R.E., Savic G., Chang J., Carson M.B., Primeaux C., Tian R., Kenton S., Jia H.G., Lin S.P., Qian Y., Li S., Zhu H., Najar F.Z., Lai H., White J., Roe B.A., Ferretti J.J. Proc. Natl. Acad. Sci. U.S.A. 99:14434-14439(2002) [PubMed: 12397186] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700610 / UA159 / Serotype c.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014133 Genomic DNA. Translation: AAN59695.1.
RefSeq	NP_722389.1.
3D structure databases
SMR	Q8DRV9. Positions 3-580.
ModBase	Search...
Genome annotation databases
GeneID	1029277.
GenomeReviews	Gene locus SMU_2101 in contig AE014133_GR.
KEGG	smu:SMU.2101.
NMPDR	fig|210007.1.peg.1902.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG396032.
OMA	PLFEYDE.
Enzyme and pathway databases
BioCyc	SMUT210007:SMU_2101-MONOMER.
BRENDA	6.1.1.12. 20716.
Family and domain databases
HAMAP	MF_00044_B. Asp_tRNA_synth_B. [Tree]
InterPro	IPR004364. aa-tRNA-synt_II. IPR018150. aa-tRNA-synt_II-like. IPR006195. aa-tRNA-synth_II_cons-dom. IPR002312. Asp-tRNA-synth_IIb. IPR020564. Asp-tRNA-synth_IIb_bac-type. IPR004524. Asp-tRNA-synth_IIb_bac/mt. IPR018153. Asp-tRNA-synth_IIb_C_bac/mt. IPR004115. GAD_dom. IPR012340. NA-bd_OB-fold. IPR016027. NA-bd_OB-fold-like. IPR004365. NA_bd_OB_tRNA-helicase. [Graphical view]
Gene3D	G3DSA:2.40.50.140. OB_NA_bd_sub. 1 hit.
PANTHER	PTHR22594. aa-tRNA-synt_II. 1 hit. PTHR22594:SF5. AspS_bac. 1 hit.
Pfam	PF02938. GAD. 1 hit. PF00152. tRNA-synt_2. 1 hit. PF01336. tRNA_anti. 1 hit. [Graphical view]
PRINTS	PR01042. TRNASYNTHASP.
TIGRFAMs	TIGR00459. aspS_bact. 1 hit.
PROSITE	PS50862. AA_TRNA_LIGASE_II. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYD2_STRMU

Accession

Primary (citable) accession number: Q8DRV9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2004
Last sequence update:	March 1, 2003
Last modified:	February 9, 2010
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)