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Q8DRR1

- SYW_STRMU

UniProt

Q8DRR1 - SYW_STRMU

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Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei205 – 2051ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. tryptophan-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. tryptophanyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSMUT210007:GC7Z-2033-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Short name:
TrpRSUniRule annotation
Gene namesi
Name:trpSUniRule annotation
Ordered Locus Names:SMU_2158c
OrganismiStreptococcus mutans serotype c (strain ATCC 700610 / UA159)
Taxonomic identifieri210007 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000002512: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 340340Tryptophan--tRNA ligasePRO_0000136689Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi210007.SMU.2158c.

Structurei

3D structure databases

ProteinModelPortaliQ8DRR1.
SMRiQ8DRR1. Positions 2-339.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi12 – 209"HIGH" region
Motifi202 – 2065"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0180.
KOiK01867.
OMAiHAGTIAH.
OrthoDBiEOG686NJQ.
PhylomeDBiQ8DRR1.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00140_B. Trp_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view]
PANTHERiPTHR10055. PTHR10055. 1 hit.
PfamiPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSiPR01039. TRNASYNTHTRP.
TIGRFAMsiTIGR00233. trpS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8DRR1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKPIILTGD RPTGKLHLGH YVGSLKNRVL LQNENKYEMF VFLADQQALT
60 70 80 90 100
DHAKESEIIK DSIANVALDY LSVGLDPEKV TIFIQSQIPE LAELTMYYMN
110 120 130 140 150
LVSLARLERN PTVKTEIAQK GFGESIPTGF LVYPISQAAD ITAFKANYVP
160 170 180 190 200
VGNDQKPMIE QTREIVRSFN HTYKTNCLVE PEGIYPKNEA AGRLPGLDGN
210 220 230 240 250
AKMSKSLGNG IFLSDDADTV RKKVMSMYTD PNHIRVEDPG QIEGNMVFHY
260 270 280 290 300
LDIFGRKEDQ TDIAAMKEHY QSGGLGDVKT KHYLLDILER ELTPIRRRRL
310 320 330 340
EYEKNMDQVL DILKKGSETA RETASETLSG VKRAMGINYF
Length:340
Mass (Da):38,326
Last modified:March 1, 2003 - v1
Checksum:iB2F78C83C8576756
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014133 Genomic DNA. Translation: AAN59747.1.
RefSeqiNP_722441.1. NC_004350.2.

Genome annotation databases

EnsemblBacteriaiAAN59747; AAN59747; SMU_2158c.
GeneIDi1029333.
KEGGismu:SMU_2158c.
PATRICi19666245. VBIStrMut61772_1920.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014133 Genomic DNA. Translation: AAN59747.1 .
RefSeqi NP_722441.1. NC_004350.2.

3D structure databases

ProteinModelPortali Q8DRR1.
SMRi Q8DRR1. Positions 2-339.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 210007.SMU.2158c.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN59747 ; AAN59747 ; SMU_2158c .
GeneIDi 1029333.
KEGGi smu:SMU_2158c.
PATRICi 19666245. VBIStrMut61772_1920.

Phylogenomic databases

eggNOGi COG0180.
KOi K01867.
OMAi HAGTIAH.
OrthoDBi EOG686NJQ.
PhylomeDBi Q8DRR1.

Enzyme and pathway databases

BioCyci SMUT210007:GC7Z-2033-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00140_B. Trp_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view ]
PANTHERi PTHR10055. PTHR10055. 1 hit.
Pfami PF00579. tRNA-synt_1b. 1 hit.
[Graphical view ]
PRINTSi PR01039. TRNASYNTHTRP.
TIGRFAMsi TIGR00233. trpS. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700610 / UA159.

Entry informationi

Entry nameiSYW_STRMU
AccessioniPrimary (citable) accession number: Q8DRR1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3