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Q8DRR1

- SYW_STRMU

UniProt

Q8DRR1 - SYW_STRMU

Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei205 – 2051ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. tryptophan-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. tryptophanyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSMUT210007:GC7Z-2033-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
    Alternative name(s):
    Tryptophanyl-tRNA synthetaseUniRule annotation
    Short name:
    TrpRSUniRule annotation
    Gene namesi
    Name:trpSUniRule annotation
    Ordered Locus Names:SMU_2158c
    OrganismiStreptococcus mutans serotype c (strain ATCC 700610 / UA159)
    Taxonomic identifieri210007 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000002512: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 340340Tryptophan--tRNA ligasePRO_0000136689Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi210007.SMU.2158c.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8DRR1.
    SMRiQ8DRR1. Positions 2-339.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi12 – 209"HIGH" region
    Motifi202 – 2065"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0180.
    KOiK01867.
    OMAiHAGTIAH.
    OrthoDBiEOG686NJQ.
    PhylomeDBiQ8DRR1.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    HAMAPiMF_00140_B. Trp_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002305. aa-tRNA-synth_Ic.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR002306. Trp-tRNA-ligase.
    IPR024109. Trp-tRNA-ligase_bac-type.
    [Graphical view]
    PANTHERiPTHR10055. PTHR10055. 1 hit.
    PfamiPF00579. tRNA-synt_1b. 1 hit.
    [Graphical view]
    PRINTSiPR01039. TRNASYNTHTRP.
    TIGRFAMsiTIGR00233. trpS. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8DRR1-1 [UniParc]FASTAAdd to Basket

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    MSKPIILTGD RPTGKLHLGH YVGSLKNRVL LQNENKYEMF VFLADQQALT    50
    DHAKESEIIK DSIANVALDY LSVGLDPEKV TIFIQSQIPE LAELTMYYMN 100
    LVSLARLERN PTVKTEIAQK GFGESIPTGF LVYPISQAAD ITAFKANYVP 150
    VGNDQKPMIE QTREIVRSFN HTYKTNCLVE PEGIYPKNEA AGRLPGLDGN 200
    AKMSKSLGNG IFLSDDADTV RKKVMSMYTD PNHIRVEDPG QIEGNMVFHY 250
    LDIFGRKEDQ TDIAAMKEHY QSGGLGDVKT KHYLLDILER ELTPIRRRRL 300
    EYEKNMDQVL DILKKGSETA RETASETLSG VKRAMGINYF 340
    Length:340
    Mass (Da):38,326
    Last modified:March 1, 2003 - v1
    Checksum:iB2F78C83C8576756
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014133 Genomic DNA. Translation: AAN59747.1.
    RefSeqiNP_722441.1. NC_004350.2.

    Genome annotation databases

    EnsemblBacteriaiAAN59747; AAN59747; SMU_2158c.
    GeneIDi1029333.
    KEGGismu:SMU_2158c.
    PATRICi19666245. VBIStrMut61772_1920.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014133 Genomic DNA. Translation: AAN59747.1 .
    RefSeqi NP_722441.1. NC_004350.2.

    3D structure databases

    ProteinModelPortali Q8DRR1.
    SMRi Q8DRR1. Positions 2-339.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 210007.SMU.2158c.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN59747 ; AAN59747 ; SMU_2158c .
    GeneIDi 1029333.
    KEGGi smu:SMU_2158c.
    PATRICi 19666245. VBIStrMut61772_1920.

    Phylogenomic databases

    eggNOGi COG0180.
    KOi K01867.
    OMAi HAGTIAH.
    OrthoDBi EOG686NJQ.
    PhylomeDBi Q8DRR1.

    Enzyme and pathway databases

    BioCyci SMUT210007:GC7Z-2033-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    HAMAPi MF_00140_B. Trp_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002305. aa-tRNA-synth_Ic.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR002306. Trp-tRNA-ligase.
    IPR024109. Trp-tRNA-ligase_bac-type.
    [Graphical view ]
    PANTHERi PTHR10055. PTHR10055. 1 hit.
    Pfami PF00579. tRNA-synt_1b. 1 hit.
    [Graphical view ]
    PRINTSi PR01039. TRNASYNTHTRP.
    TIGRFAMsi TIGR00233. trpS. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700610 / UA159.

    Entry informationi

    Entry nameiSYW_STRMU
    AccessioniPrimary (citable) accession number: Q8DRR1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3