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Q8DRR1 (SYW_STRMU) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tryptophan--tRNA ligase

EC=6.1.1.2
Alternative name(s):
Tryptophanyl-tRNA synthetase
Short name=TrpRS
Gene names
Name:trpS
Ordered Locus Names:SMU_2158c
OrganismStreptococcus mutans serotype c (strain ATCC 700610 / UA159) [Complete proteome] [HAMAP]
Taxonomic identifier210007 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length340 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp). HAMAP-Rule MF_00140

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00140

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00140.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processtryptophanyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

tryptophan-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 340340Tryptophan--tRNA ligase HAMAP-Rule MF_00140
PRO_0000136689

Regions

Motif12 – 209"HIGH" region HAMAP-Rule MF_00140
Motif202 – 2065"KMSKS" region HAMAP-Rule MF_00140

Sites

Binding site2051ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8DRR1 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: B2F78C83C8576756

FASTA34038,326
        10         20         30         40         50         60 
MSKPIILTGD RPTGKLHLGH YVGSLKNRVL LQNENKYEMF VFLADQQALT DHAKESEIIK 

        70         80         90        100        110        120 
DSIANVALDY LSVGLDPEKV TIFIQSQIPE LAELTMYYMN LVSLARLERN PTVKTEIAQK 

       130        140        150        160        170        180 
GFGESIPTGF LVYPISQAAD ITAFKANYVP VGNDQKPMIE QTREIVRSFN HTYKTNCLVE 

       190        200        210        220        230        240 
PEGIYPKNEA AGRLPGLDGN AKMSKSLGNG IFLSDDADTV RKKVMSMYTD PNHIRVEDPG 

       250        260        270        280        290        300 
QIEGNMVFHY LDIFGRKEDQ TDIAAMKEHY QSGGLGDVKT KHYLLDILER ELTPIRRRRL 

       310        320        330        340 
EYEKNMDQVL DILKKGSETA RETASETLSG VKRAMGINYF 

« Hide

References

[1]"Genome sequence of Streptococcus mutans UA159, a cariogenic dental pathogen."
Ajdic D.J., McShan W.M., McLaughlin R.E., Savic G., Chang J., Carson M.B., Primeaux C., Tian R., Kenton S., Jia H.G., Lin S.P., Qian Y., Li S., Zhu H., Najar F.Z., Lai H., White J., Roe B.A., Ferretti J.J.
Proc. Natl. Acad. Sci. U.S.A. 99:14434-14439(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700610 / UA159.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE014133 Genomic DNA. Translation: AAN59747.1.
RefSeqNP_722441.1. NC_004350.2.

3D structure databases

ProteinModelPortalQ8DRR1.
SMRQ8DRR1. Positions 2-339.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING210007.SMU.2158c.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAN59747; AAN59747; SMU_2158c.
GeneID1029333.
KEGGsmu:SMU_2158c.
PATRIC19666245. VBIStrMut61772_1920.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0180.
KOK01867.
OMAHAGTIAH.
OrthoDBEOG686NJQ.
PhylomeDBQ8DRR1.

Enzyme and pathway databases

BioCycSMUT210007:GC7Z-2033-MONOMER.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
HAMAPMF_00140_B. Trp_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view]
PANTHERPTHR10055. PTHR10055. 1 hit.
PfamPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSPR01039. TRNASYNTHTRP.
TIGRFAMsTIGR00233. trpS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYW_STRMU
AccessionPrimary (citable) accession number: Q8DRR1
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries