SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8DRM4

- PUR5_STRR6

UniProt

Q8DRM4 - PUR5_STRR6

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene
purM, spr0048
Organism
Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSPNE171101:GJC8-55-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase (EC:6.3.3.1)
Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase
Gene namesi
Name:purM
Ordered Locus Names:spr0048
OrganismiStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Taxonomic identifieri171101 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000586: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 340340Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotationPRO_0000148260Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi171101.spr0048.

Structurei

3D structure databases

ProteinModelPortaliQ8DRM4.
SMRiQ8DRM4. Positions 15-333.

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229091.
KOiK01933.
OMAiPDMYGAD.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741_B. AIRS_B.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8DRM4-1 [UniParc]FASTAAdd to Basket

« Hide

MTNKNAYAQS GVDVEAGYEV VERIKKHVAR TERAGVMGAL GGFGGMFDLS    50
KTGVKEPVLI SGTDGVGTKL MLAIKYDKHD TIGQDCVAMC VNDIIAAGAE 100
PLYFLDYVAT GKNEPAKLEQ VVAGVAEGCV QAGAALIGGE TAEMPGMYGE 150
DDYDLAGFAV GVAEKSQIID GSKVVEGDVL LGLVSSGIHS NGYSLVRRVF 200
ADYTGEEVLP ELEGKKLKEV LLEPTRIYVK AVLPLIKEEL VNGIAHITGG 250
GFIENVPRMF ADDLAAEIDE SKVPVLPIFK ALEKYGQIKH EEMFEIFNMG 300
VGLMLAVSPE NVERVKELLD EAVYEIGRIV KKENESVIIK 340
Length:340
Mass (Da):36,530
Last modified:March 1, 2003 - v1
Checksum:iBD56E9E431AB669C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE007317 Genomic DNA. Translation: AAK98852.1.
PIRiH97877.
RefSeqiNP_357642.1. NC_003098.1.

Genome annotation databases

EnsemblBacteriaiAAK98852; AAK98852; spr0048.
GeneIDi933451.
KEGGispr:spr0048.
PATRICi19699875. VBIStrPne107296_0056.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE007317 Genomic DNA. Translation: AAK98852.1 .
PIRi H97877.
RefSeqi NP_357642.1. NC_003098.1.

3D structure databases

ProteinModelPortali Q8DRM4.
SMRi Q8DRM4. Positions 15-333.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 171101.spr0048.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK98852 ; AAK98852 ; spr0048 .
GeneIDi 933451.
KEGGi spr:spr0048.
PATRICi 19699875. VBIStrPne107296_0056.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229091.
KOi K01933.
OMAi PDMYGAD.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci SPNE171101:GJC8-55-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741_B. AIRS_B.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-255 / R6.

Entry informationi

Entry nameiPUR5_STRR6
AccessioniPrimary (citable) accession number: Q8DRM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi