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Q8DRM0 (PUR2_STRR6) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoribosylamine--glycine ligase

EC=6.3.4.13
Alternative name(s):
GARS
Glycinamide ribonucleotide synthetase
Phosphoribosylglycinamide synthetase
Gene names
Name:purD
Ordered Locus Names:spr0052
OrganismStreptococcus pneumoniae (strain ATCC BAA-255 / R6) [Reference proteome] [HAMAP]
Taxonomic identifier171101 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length420 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide. HAMAP-Rule MF_00138

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity.

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2. HAMAP-Rule MF_00138

Sequence similarities

Belongs to the GARS family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 420420Phosphoribosylamine--glycine ligase HAMAP-Rule MF_00138
PRO_0000151488

Regions

Domain108 – 314207ATP-grasp
Nucleotide binding134 – 19562ATP By similarity

Sites

Metal binding2841Magnesium or manganese By similarity
Metal binding2861Magnesium or manganese By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8DRM0 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 2A1F2C5273040373

FASTA42045,302
        10         20         30         40         50         60 
MKLLVVGSGG REHAIAKKLL ESKDVEKVFV APGNDGMTLD GLELVNISIS EHSKLIDFAK 

        70         80         90        100        110        120 
TNDVAWTFIG PDDALAAGIV DDFNQAGLKA FGPTRAAAEL EWSKDFAKEI MVKYGVSTAA 

       130        140        150        160        170        180 
YGTFSDFEEA KAYIEKHGAP IVVKADGLAL GKGVVVAETV EQAVEAAHEM LLDNKFGDSG 

       190        200        210        220        230        240 
ARVVIEEFLE GEEFSLFAFV NGDKFYIMPT AQDHKRAYDG DKGPNTGGMG AYAPVPHLPQ 

       250        260        270        280        290        300 
SVVDTAVDTI VKPVLEGIIK EGRPYLGVIY AGLILTADGP KVIEFNSRFG DPETQIILPR 

       310        320        330        340        350        360 
LTSDFAQNIT DILDGKEPNI MWTDKGVTLG VVVASKGYPL DYERGVELPA KTEGDVITYY 

       370        380        390        400        410        420 
AGAKFAENSR ALLSNGGRVY MLVTTADTVK EAQASIYQEL SQQKIEGLFY RTDIGSKAIK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE007317 Genomic DNA. Translation: AAK98856.1.
PIRD97878.
RefSeqNP_357646.1. NC_003098.1.

3D structure databases

ProteinModelPortalQ8DRM0.
SMRQ8DRM0. Positions 1-420.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING171101.spr0052.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK98856; AAK98856; spr0052.
GeneID933188.
KEGGspr:spr0052.
PATRIC19699883. VBIStrPne107296_0060.

Phylogenomic databases

eggNOGCOG0151.
HOGENOMHOG000033463.
KOK01945.
OrthoDBEOG69SKD1.

Enzyme and pathway databases

BioCycSPNE171101:GJC8-59-MONOMER.
UniPathwayUPA00074; UER00125.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
3.90.600.10. 1 hit.
HAMAPMF_00138. GARS.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR020561. PRibGlycinamid_synth_ATP-grasp.
IPR000115. PRibGlycinamide_synth.
IPR020560. PRibGlycinamide_synth_C-dom.
IPR020559. PRibGlycinamide_synth_CS.
IPR020562. PRibGlycinamide_synth_N.
IPR011054. Rudment_hybrid_motif.
[Graphical view]
PfamPF01071. GARS_A. 1 hit.
PF02843. GARS_C. 1 hit.
PF02844. GARS_N. 1 hit.
[Graphical view]
SUPFAMSSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR00877. purD. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00184. GARS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePUR2_STRR6
AccessionPrimary (citable) accession number: Q8DRM0
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways