Q8DRE2 (RUVX_STRR6) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative Holliday junction resolvase
EC=3.1.-.-

Gene names

Ordered Locus Names:

spr0176

Organism

Streptococcus pneumoniae (strain ATCC BAA-255 / R6) [Reference proteome] [HAMAP]

Taxonomic identifier

171101 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus › Streptococcus pneumoniae

Protein attributes

Sequence length	139 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination By similarity. HAMAP-Rule MF_00651
Subcellular location	Cytoplasm Potential HAMAP-Rule MF_00651.
Sequence similarities	Belongs to the YqgF HJR family.

Ontologies

Keywords
Biological process	DNA damage DNA recombination DNA repair
Cellular component	Cytoplasm
Molecular function	Hydrolase Nuclease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA recombination Inferred from electronic annotation. Source: HAMAP DNA repair Inferred from electronic annotation. Source: HAMAP nucleic acid phosphodiester bond hydrolysis Inferred from electronic annotation. Source: GOC
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	nuclease activity Inferred from electronic annotation. Source: UniProtKB-KW nucleic acid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 139	139	Putative Holliday junction resolvase HAMAP-Rule MF_00651		PRO_0000172150

Sequences

	Sequence		Length	Mass (Da)
	Q8DRE2 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 597A484F224EC8BD	FASTA	139	15,655
	10 20 30 40 50 60 MRIMGLDVGS KTVGVAISDP LGFTAQGLEI IQINEEQGQF GFDRVKELVD TYKVERFVVG 70 80 90 100 110 120 LPKNMNNTSG PRVEASQAYG AKLEEFFGLP VDYQDERLTT VAAERMLIEQ ADISRNKRKK 130 VIDKLAAQLI LQNYLDRKF

References

[1]

"Genome of the bacterium Streptococcus pneumoniae strain R6." Hoskins J., Alborn W.E. Jr., Arnold J., Blaszczak L.C., Burgett S., DeHoff B.S., Estrem S.T., Fritz L., Fu D.-J., Fuller W., Geringer C., Gilmour R., Glass J.S., Khoja H., Kraft A.R., Lagace R.E., LeBlanc D.J., Lee L.N. , Lefkowitz E.J., Lu J., Matsushima P., McAhren S.M., McHenney M., McLeaster K., Mundy C.W., Nicas T.I., Norris F.H., O'Gara M., Peery R.B., Robertson G.T., Rockey P., Sun P.-M., Winkler M.E., Yang Y., Young-Bellido M., Zhao G., Zook C.A., Baltz R.H., Jaskunas S.R., Rosteck P.R. Jr., Skatrud P.L., Glass J.I. J. Bacteriol. 183:5709-5717(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-255 / R6.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE007317 Genomic DNA. Translation: AAK98980.1.
PIR	H97893.
RefSeq	NP_357770.1. NC_003098.1.
3D structure databases
ProteinModelPortal	Q8DRE2.
SMR	Q8DRE2. Positions 1-138.
ModBase	Search...
Protein-protein interaction databases
STRING	171101.spr0176.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAK98980; AAK98980; spr0176.
GeneID	933212.
KEGG	spr:spr0176.
PATRIC	19700175. VBIStrPne107296_0208.
Phylogenomic databases
eggNOG	COG0816.
HOGENOM	HOG000016953.
KO	K07447.
OMA	KNMNGTV.
ProtClustDB	PRK00109.
Family and domain databases
Gene3D	3.30.420.140. 1 hit.
HAMAP	MF_00651. HJR_YqgF.
InterPro	IPR005227. Resolv_Hlld_junc_YqgF-like. IPR012337. RNaseH-like_dom. IPR006641. YqgF/RNaseH-like_dom. [Graphical view]
Pfam	PF03652. UPF0081. 1 hit. [Graphical view]
SMART	SM00732. YqgFc. 1 hit. [Graphical view]
SUPFAM	SSF53098. RNaseH_fold. 1 hit.
TIGRFAMs	TIGR00250. RNAse_H_YqgF. 1 hit.
ProtoNet	Search...

Entry information

Entry name

RUVX_STRR6

Accession

Primary (citable) accession number: Q8DRE2

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 16, 2003
Last sequence update:	March 1, 2003
Last modified:	May 1, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program