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Protein

Isoprenyl transferase

Gene

uppS

Organism
Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei28 – 281UniRule annotation
Metal bindingi28 – 281MagnesiumUniRule annotation
Binding sitei33 – 331SubstrateUniRule annotation
Binding sitei41 – 411SubstrateUniRule annotation
Binding sitei45 – 451SubstrateUniRule annotation
Active sitei76 – 761Proton acceptorUniRule annotation
Binding sitei77 – 771SubstrateUniRule annotation
Binding sitei79 – 791SubstrateUniRule annotation
Binding sitei200 – 2001SubstrateUniRule annotation
Metal bindingi219 – 2191MagnesiumUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciSPNE171101:GJC8-247-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isoprenyl transferaseUniRule annotation (EC:2.5.1.-UniRule annotation)
Gene namesi
Name:uppSUniRule annotation
Ordered Locus Names:spr0240
OrganismiStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Taxonomic identifieri171101 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000000586 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 252252Isoprenyl transferasePRO_0000123691Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi171101.spr0240.

Structurei

Secondary structure

1
252
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi21 – 266Combined sources
Helixi30 – 356Combined sources
Turni36 – 383Combined sources
Helixi41 – 6222Combined sources
Beta strandi66 – 738Combined sources
Helixi74 – 785Combined sources
Helixi81 – 9313Combined sources
Helixi95 – 10410Combined sources
Beta strandi108 – 1136Combined sources
Helixi115 – 1173Combined sources
Helixi120 – 13314Combined sources
Beta strandi140 – 1478Combined sources
Helixi149 – 16517Combined sources
Helixi171 – 1733Combined sources
Helixi176 – 1805Combined sources
Helixi184 – 1874Combined sources
Helixi190 – 1923Combined sources
Beta strandi196 – 2005Combined sources
Beta strandi209 – 2113Combined sources
Turni212 – 2176Combined sources
Beta strandi219 – 2224Combined sources
Helixi227 – 2293Combined sources
Helixi232 – 24312Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4Q9MX-ray2.06A/B10-252[»]
4Q9OX-ray2.20A/B10-252[»]
ProteinModelPortaliQ8DRB3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni29 – 324Substrate bindingUniRule annotation
Regioni73 – 753Substrate bindingUniRule annotation
Regioni206 – 2083Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the UPP synthase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CR3. Bacteria.
COG0020. LUCA.
HOGENOMiHOG000006055.
KOiK00806.
OrthoDBiEOG68H89T.

Family and domain databases

Gene3Di3.40.1180.10. 1 hit.
HAMAPiMF_01139. ISPT.
InterProiIPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
[Graphical view]
PANTHERiPTHR10291. PTHR10291. 1 hit.
PfamiPF01255. Prenyltransf. 1 hit.
[Graphical view]
SUPFAMiSSF64005. SSF64005. 1 hit.
TIGRFAMsiTIGR00055. uppS. 1 hit.
PROSITEiPS01066. UPP_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8DRB3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFGFFKKDKA VEVEVPTQVP AHIGIIMDGN GRWAKKRMQP RVFGHKAGME
60 70 80 90 100
ALQTVTKAAN KLGVKVITVY AFSTENWTRP DQEVKFIMNL PVEFYDNYVP
110 120 130 140 150
ELHANNVKIQ MIGETDRLPK QTFEALTKAE ELTKNNTGLI LNFALNYGGR
160 170 180 190 200
AEITQALKLI SQDVLDAKIN PGDITEELIG NYLFTQHLPK DLRDPDLIIR
210 220 230 240 250
TSGELRLSNF LPWQGAYSEL YFTDTLWPDF DEAALQEAIL AYNRRHRRFG

GV
Length:252
Mass (Da):28,705
Last modified:February 16, 2004 - v2
Checksum:i4859F158422293D6
GO

Sequence cautioni

The sequence AAK99044.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE007317 Genomic DNA. Translation: AAK99044.1. Different initiation.
PIRiH97901.
RefSeqiNP_357834.1. NC_003098.1.

Genome annotation databases

EnsemblBacteriaiAAK99044; AAK99044; spr0240.
GeneIDi934063.
KEGGispr:spr0240.
PATRICi19700307. VBIStrPne107296_0274.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE007317 Genomic DNA. Translation: AAK99044.1. Different initiation.
PIRiH97901.
RefSeqiNP_357834.1. NC_003098.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4Q9MX-ray2.06A/B10-252[»]
4Q9OX-ray2.20A/B10-252[»]
ProteinModelPortaliQ8DRB3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi171101.spr0240.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK99044; AAK99044; spr0240.
GeneIDi934063.
KEGGispr:spr0240.
PATRICi19700307. VBIStrPne107296_0274.

Phylogenomic databases

eggNOGiENOG4105CR3. Bacteria.
COG0020. LUCA.
HOGENOMiHOG000006055.
KOiK00806.
OrthoDBiEOG68H89T.

Enzyme and pathway databases

BioCyciSPNE171101:GJC8-247-MONOMER.

Family and domain databases

Gene3Di3.40.1180.10. 1 hit.
HAMAPiMF_01139. ISPT.
InterProiIPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
[Graphical view]
PANTHERiPTHR10291. PTHR10291. 1 hit.
PfamiPF01255. Prenyltransf. 1 hit.
[Graphical view]
SUPFAMiSSF64005. SSF64005. 1 hit.
TIGRFAMsiTIGR00055. uppS. 1 hit.
PROSITEiPS01066. UPP_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-255 / R6.

Entry informationi

Entry nameiISPT_STRR6
AccessioniPrimary (citable) accession number: Q8DRB3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: February 16, 2004
Last modified: July 6, 2016
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.