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Protein

Isoprenyl transferase

Gene

uppS

Organism
Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei28UniRule annotation1
Metal bindingi28MagnesiumUniRule annotation1
Binding sitei33SubstrateUniRule annotation1
Binding sitei41SubstrateUniRule annotation1
Binding sitei45SubstrateUniRule annotation1
Active sitei76Proton acceptorUniRule annotation1
Binding sitei77SubstrateUniRule annotation1
Binding sitei79SubstrateUniRule annotation1
Binding sitei200SubstrateUniRule annotation1
Metal bindingi219MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Isoprenyl transferaseUniRule annotation (EC:2.5.1.-UniRule annotation)
Gene namesi
Name:uppSUniRule annotation
Ordered Locus Names:spr0240
OrganismiStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Taxonomic identifieri171101 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000000586 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001236911 – 252Isoprenyl transferaseAdd BLAST252

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi171101.spr0240.

Structurei

Secondary structure

1252
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi21 – 26Combined sources6
Helixi30 – 35Combined sources6
Turni36 – 38Combined sources3
Helixi41 – 62Combined sources22
Beta strandi66 – 73Combined sources8
Helixi74 – 78Combined sources5
Helixi81 – 93Combined sources13
Helixi95 – 104Combined sources10
Beta strandi108 – 113Combined sources6
Helixi115 – 117Combined sources3
Helixi120 – 133Combined sources14
Beta strandi140 – 147Combined sources8
Helixi149 – 165Combined sources17
Helixi171 – 173Combined sources3
Helixi176 – 180Combined sources5
Helixi184 – 187Combined sources4
Helixi190 – 192Combined sources3
Beta strandi196 – 200Combined sources5
Beta strandi209 – 211Combined sources3
Turni212 – 217Combined sources6
Beta strandi219 – 222Combined sources4
Helixi227 – 229Combined sources3
Helixi232 – 243Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4Q9MX-ray2.06A/B10-252[»]
4Q9OX-ray2.20A/B10-252[»]
ProteinModelPortaliQ8DRB3.
SMRiQ8DRB3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni29 – 32Substrate bindingUniRule annotation4
Regioni73 – 75Substrate bindingUniRule annotation3
Regioni206 – 208Substrate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the UPP synthase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CR3. Bacteria.
COG0020. LUCA.
HOGENOMiHOG000006055.
KOiK00806.

Family and domain databases

CDDicd00475. Cis_IPPS. 1 hit.
Gene3Di3.40.1180.10. 1 hit.
HAMAPiMF_01139. ISPT. 1 hit.
InterProiIPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
[Graphical view]
PANTHERiPTHR10291. PTHR10291. 1 hit.
PfamiPF01255. Prenyltransf. 1 hit.
[Graphical view]
SUPFAMiSSF64005. SSF64005. 1 hit.
TIGRFAMsiTIGR00055. uppS. 1 hit.
PROSITEiPS01066. UPP_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8DRB3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFGFFKKDKA VEVEVPTQVP AHIGIIMDGN GRWAKKRMQP RVFGHKAGME
60 70 80 90 100
ALQTVTKAAN KLGVKVITVY AFSTENWTRP DQEVKFIMNL PVEFYDNYVP
110 120 130 140 150
ELHANNVKIQ MIGETDRLPK QTFEALTKAE ELTKNNTGLI LNFALNYGGR
160 170 180 190 200
AEITQALKLI SQDVLDAKIN PGDITEELIG NYLFTQHLPK DLRDPDLIIR
210 220 230 240 250
TSGELRLSNF LPWQGAYSEL YFTDTLWPDF DEAALQEAIL AYNRRHRRFG

GV
Length:252
Mass (Da):28,705
Last modified:February 16, 2004 - v2
Checksum:i4859F158422293D6
GO

Sequence cautioni

The sequence AAK99044 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE007317 Genomic DNA. Translation: AAK99044.1. Different initiation.
PIRiH97901.
RefSeqiNP_357834.1. NC_003098.1.
WP_010976409.1. NC_003098.1.

Genome annotation databases

EnsemblBacteriaiAAK99044; AAK99044; spr0240.
GeneIDi934063.
KEGGispr:spr0240.
PATRICi19700307. VBIStrPne107296_0274.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE007317 Genomic DNA. Translation: AAK99044.1. Different initiation.
PIRiH97901.
RefSeqiNP_357834.1. NC_003098.1.
WP_010976409.1. NC_003098.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4Q9MX-ray2.06A/B10-252[»]
4Q9OX-ray2.20A/B10-252[»]
ProteinModelPortaliQ8DRB3.
SMRiQ8DRB3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi171101.spr0240.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK99044; AAK99044; spr0240.
GeneIDi934063.
KEGGispr:spr0240.
PATRICi19700307. VBIStrPne107296_0274.

Phylogenomic databases

eggNOGiENOG4105CR3. Bacteria.
COG0020. LUCA.
HOGENOMiHOG000006055.
KOiK00806.

Family and domain databases

CDDicd00475. Cis_IPPS. 1 hit.
Gene3Di3.40.1180.10. 1 hit.
HAMAPiMF_01139. ISPT. 1 hit.
InterProiIPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
[Graphical view]
PANTHERiPTHR10291. PTHR10291. 1 hit.
PfamiPF01255. Prenyltransf. 1 hit.
[Graphical view]
SUPFAMiSSF64005. SSF64005. 1 hit.
TIGRFAMsiTIGR00055. uppS. 1 hit.
PROSITEiPS01066. UPP_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiISPT_STRR6
AccessioniPrimary (citable) accession number: Q8DRB3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: February 16, 2004
Last modified: November 2, 2016
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.