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Q8DRA8

- GLMS_STRR6

UniProt

Q8DRA8 - GLMS_STRR6

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Protein
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]
Gene
glmS, spr0245
Organism
Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source By similarity.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activity By similarity
Active sitei597 – 5971For Fru-6P isomerization activity By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

BioCyciSPNE171101:GJC8-252-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC:2.6.1.16)
Alternative name(s):
D-fructose-6-phosphate amidotransferase
GFAT
Glucosamine-6-phosphate synthase
Hexosephosphate aminotransferase
L-glutamine--D-fructose-6-phosphate amidotransferase
Gene namesi
Name:glmS
Ordered Locus Names:spr0245
OrganismiStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Taxonomic identifieri171101 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000586: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 602601Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation
PRO_0000135392Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi171101.spr0245.

Structurei

3D structure databases

ProteinModelPortaliQ8DRA8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 217216Glutamine amidotransferase type-2
Add
BLAST
Domaini283 – 422140SIS 1
Add
BLAST
Domaini455 – 592138SIS 2
Add
BLAST

Sequence similaritiesi

Contains 2 SIS domains.

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
HOGENOMiHOG000258896.
KOiK00820.
OMAiSVFETQT.
OrthoDBiEOG6KT2Q1.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8DRA8-1 [UniParc]FASTAAdd to Basket

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MCGIVGVVGN TNATDILIQG LEKLEYRGYD SAGIFVLDGA DNHLVKAVGR    50
IAELSAKTAG VEGTTGIGHT RWATHGKPTE DNAHPHRSET ERFVLVHNGV 100
IENYLEIKEE YLAGHHFKGQ TDTEIAVHLI GKFAEEDGLS VLEAFKKALH 150
IIRGSYAFAL IDSENPDVIY VAKNKSPLLI GLGEGYNMVC SDAMAMIRET 200
NQYMEIHDQE LVIVKADSVE VQDYDGNSRE RASYTAELDL SDIGKGTYPY 250
YMLKEIDEQP TVMRKLIQAY TDDAGQVVID PAIIKAVQDA DRIYILAAGT 300
SYHAGFASKK MLEELTDTPV ELGISSEWGY GMPLLSKKPL FIFISQSGET 350
ADSRQVLVKA NEMGIPSLTV TNVPGSTLSR EANYTMLLHA GPEIAVASTK 400
AYTAQIAALA FLAKAVGEAN GNAKAQAFDL VHELSIVAQS IESTLSEKET 450
IEAKVRELLE TTRNAFYIGR GQDYYVAMEA SLKLKEISYI QCEGFAAGEL 500
KHGTIALIEE GTPVLALLSD PVLANHTRGN IQEVAARGAK VLTIAEENVA 550
KDTDDIVLTT VHPYLSPISM VVPTQLVAYF ATLHRGLDVD KPRNLAKSVT 600
VE 602
Length:602
Mass (Da):65,478
Last modified:January 23, 2007 - v3
Checksum:i2E60BED468791B1C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE007317 Genomic DNA. Translation: AAK99049.1.
PIRiE97902.
RefSeqiNP_357839.1. NC_003098.1.

Genome annotation databases

EnsemblBacteriaiAAK99049; AAK99049; spr0245.
GeneIDi932810.
KEGGispr:spr0245.
PATRICi19700317. VBIStrPne107296_0279.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE007317 Genomic DNA. Translation: AAK99049.1 .
PIRi E97902.
RefSeqi NP_357839.1. NC_003098.1.

3D structure databases

ProteinModelPortali Q8DRA8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 171101.spr0245.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK99049 ; AAK99049 ; spr0245 .
GeneIDi 932810.
KEGGi spr:spr0245.
PATRICi 19700317. VBIStrPne107296_0279.

Phylogenomic databases

eggNOGi COG0449.
HOGENOMi HOG000258896.
KOi K00820.
OMAi SVFETQT.
OrthoDBi EOG6KT2Q1.

Enzyme and pathway databases

BioCyci SPNE171101:GJC8-252-MONOMER.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-255 / R6.

Entry informationi

Entry nameiGLMS_STRR6
AccessioniPrimary (citable) accession number: Q8DRA8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2003
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 77 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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