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Protein

Penicillin-binding protein 1A

Gene

pbpA

Organism
Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cell wall formation.

Catalytic activityi

(GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala))(n)-diphosphoundecaprenol + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = (GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala))(n+1)-diphosphoundecaprenol + undecaprenyl diphosphate.By similarity
Preferential cleavage: (Ac)2-L-Lys-D-Ala-|-D-Ala. Also transpeptidation of peptidyl-alanyl moieties that are N-acyl substituents of D-alanine.By similarity

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei91Proton donor; for transglycosylase activityBy similarity1
Active sitei370Acyl-ester intermediate; for transpeptidase activityBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCarboxypeptidase, Glycosyltransferase, Hydrolase, Multifunctional enzyme, Protease, Transferase
Biological processAntibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciSPNE171101:G1FZH-350-MONOMER
UniPathwayiUPA00219

Protein family/group databases

CAZyiGT51 Glycosyltransferase Family 51

Names & Taxonomyi

Protein namesi
Recommended name:
Penicillin-binding protein 1A
Short name:
PBP-1A
Alternative name(s):
Exported protein 2
Including the following 2 domains:
Penicillin-insensitive transglycosylase (EC:2.4.1.129By similarity)
Alternative name(s):
Peptidoglycan TGase
Penicillin-sensitive transpeptidase (EC:3.4.16.4By similarity)
Alternative name(s):
DD-transpeptidase
Gene namesi
Name:pbpA
Synonyms:exp2
Ordered Locus Names:spr0329
OrganismiStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Taxonomic identifieri171101 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000000586 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Chemistry databases

DrugBankiDB01163 Amdinocillin
DB00415 Ampicillin
DB08795 Azidocillin
DB01140 Cefadroxil
DB00456 Cefalotin
DB00493 Cefotaxime
DB01331 Cefoxitin
DB00438 Ceftazidime
DB00567 Cephalexin
DB03313 Cephalosporin C
DB01000 Cyclacillin
DB00485 Dicloxacillin
DB00739 Hetacillin
DB01603 Meticillin
DB00607 Nafcillin
DB00713 Oxacillin
DB08375 PCNOTAXIME GROUP

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000831831 – 719Penicillin-binding protein 1AAdd BLAST719

Proteomic databases

PRIDEiQ8DR59

Interactioni

Protein-protein interaction databases

STRINGi171101.spr0329

Structurei

Secondary structure

1719
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi54 – 56Combined sources3
Beta strandi62 – 65Combined sources4
Helixi270 – 272Combined sources3
Helixi273 – 287Combined sources15
Turni291 – 293Combined sources3
Beta strandi296 – 300Combined sources5
Helixi304 – 315Combined sources12
Beta strandi317 – 319Combined sources3
Beta strandi323 – 325Combined sources3
Beta strandi328 – 335Combined sources8
Turni336 – 338Combined sources3
Beta strandi340 – 345Combined sources6
Turni360 – 362Combined sources3
Helixi369 – 371Combined sources3
Helixi372 – 376Combined sources5
Helixi378 – 383Combined sources6
Beta strandi388 – 391Combined sources4
Beta strandi393 – 398Combined sources6
Beta strandi417 – 420Combined sources4
Helixi421 – 426Combined sources6
Helixi430 – 440Combined sources11
Helixi442 – 450Combined sources9
Turni451 – 453Combined sources3
Helixi461 – 464Combined sources4
Beta strandi474 – 477Combined sources4
Helixi480 – 491Combined sources12
Beta strandi494 – 497Combined sources4
Beta strandi500 – 507Combined sources8
Beta strandi512 – 514Combined sources3
Beta strandi519 – 521Combined sources3
Helixi525 – 541Combined sources17
Helixi545 – 547Combined sources3
Beta strandi555 – 560Combined sources6
Helixi565 – 570Combined sources6
Beta strandi578 – 580Combined sources3
Beta strandi582 – 587Combined sources6
Beta strandi589 – 598Combined sources10
Helixi608 – 612Combined sources5
Helixi613 – 626Combined sources14
Beta strandi627 – 629Combined sources3
Beta strandi640 – 643Combined sources4
Beta strandi646 – 649Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2C5WX-ray2.55A51-66[»]
B266-650[»]
2C6WX-ray2.61A51-66[»]
B267-650[»]
2V2FX-ray1.90A47-70[»]
2ZC5X-ray3.00A/C47-70[»]
2ZC6X-ray2.70A/C47-70[»]
ProteinModelPortaliQ8DR59
SMRiQ8DR59
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8DR59

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni62 – 223TransglycosylaseBy similarityAdd BLAST162
Regioni297 – 611TranspeptidaseBy similarityAdd BLAST315

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi654 – 691Ser-richAdd BLAST38

Sequence similaritiesi

In the N-terminal section; belongs to the glycosyltransferase 51 family.Curated
In the C-terminal section; belongs to the transpeptidase family.Curated

Phylogenomic databases

eggNOGiENOG4105BZ4 Bacteria
COG0744 LUCA
HOGENOMiHOG000041140
KOiK05366
OMAiLAQMAMI

Family and domain databases

Gene3Di1.10.3810.10, 1 hit
InterProiView protein in InterPro
IPR012338 Beta-lactam/transpept-like
IPR001264 Glyco_trans_51
IPR023346 Lysozyme-like_dom_sf
IPR036950 PBP_transglycosylase
IPR001460 PCN-bd_Tpept
PfamiView protein in Pfam
PF00912 Transgly, 1 hit
PF00905 Transpeptidase, 1 hit
SUPFAMiSSF53955 SSF53955, 1 hit
SSF56601 SSF56601, 2 hits

Sequencei

Sequence statusi: Complete.

Q8DR59-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKPTILRLI KYLSISFLSL VIAAIVLGGG VFFYYVSKAP SLSESKLVAT
60 70 80 90 100
TSSKIYDNKN QLIADLGSER RVNAQANDIP TDLVKAIVSI EDHRFFDHRG
110 120 130 140 150
IDTIRILGAF LRNLQSNSLQ GGSALTQQLI KLTYFSTSTS DQTISRKAQE
160 170 180 190 200
AWLAIQLEQK ATKQEILTYY INKVYMSNGN YGMQTAAQNY YGKDLNNLSL
210 220 230 240 250
PQLALLAGMP QAPNQYDPYS HPEAAQDRRN LVLSEMKNQG YISAEQYEKA
260 270 280 290 300
VNTPITDGLQ SLKSASNYPA YMDNYLKEVI NQVEEETGYN LLTTGMDVYT
310 320 330 340 350
NVDQEAQKHL WDIYNTDEYV AYPDDELQVA STIVDVSNGK VIAQLGARHQ
360 370 380 390 400
SSNVSFGINQ AVETNRDWGS TMKPITDYAP ALEYGVYEST ATIVHDEPYN
410 420 430 440 450
YPGTNTPVYN WDRGYFGNIT LQYALQQSRN VPAVETLNKV GLNRAKTFLN
460 470 480 490 500
GLGIDYPSIH YSNAISSNTT ESDKKYGASS EKMAAAYAAF ANGGTYYKPM
510 520 530 540 550
YIHKVVFSDG SEKEFSNVGT RAMKETTAYM MTDMMKTVLS YGTGRNAYLA
560 570 580 590 600
WLPQAGKTGT SNYTDEEIEN HIKTSQFVAP DELFAGYTRK YSMAVWTGYS
610 620 630 640 650
NRLTPLVGNG LTVAAKVYRS MMTYLSEGSN PEDWNIPEGL YRNGEFVFKN
660 670 680 690 700
GARSTWSSPA PQQPPSTESS SSSSDSSTSQ SSSTTPSTNN STTTNPNNNT
710
QQSNTTPDQQ NQNPQPAQP
Length:719
Mass (Da):79,701
Last modified:March 1, 2003 - v1
Checksum:i14537A7070799EE6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M90527 Genomic DNA Translation: AAA26956.1
AE007317 Genomic DNA Translation: AAK99133.1
PIRiA42893
A97913
RefSeqiNP_357923.1, NC_003098.1
WP_001039991.1, NC_003098.1

Genome annotation databases

EnsemblBacteriaiAAK99133; AAK99133; spr0329
GeneIDi934791
KEGGispr:spr0329
PATRICifig|171101.6.peg.368

Similar proteinsi

Entry informationi

Entry nameiPBPA_STRR6
AccessioniPrimary (citable) accession number: Q8DR59
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: March 1, 2003
Last modified: May 23, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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