Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Penicillin-binding protein 1A

Gene

pbpA

Organism
Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Cell wall formation.

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei370 – 3701Acyl-ester intermediateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciSPNE171101:GJC8-336-MONOMER.
UniPathwayiUPA00219.

Protein family/group databases

CAZyiGT51. Glycosyltransferase Family 51.

Names & Taxonomyi

Protein namesi
Recommended name:
Penicillin-binding protein 1A
Short name:
PBP-1A
Alternative name(s):
Exported protein 2
Gene namesi
Name:pbpA
Synonyms:exp2
Ordered Locus Names:spr0329
OrganismiStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Taxonomic identifieri171101 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000000586 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Chemistry

DrugBankiDB00415. Ampicillin.
DB08795. Azidocillin.
DB01140. Cefadroxil.
DB00456. Cefalotin.
DB00493. Cefotaxime.
DB01331. Cefoxitin.
DB00438. Ceftazidime.
DB00567. Cephalexin.
DB01000. Cyclacillin.
DB00485. Dicloxacillin.
DB00739. Hetacillin.
DB01603. Meticillin.
DB00607. Nafcillin.
DB00713. Oxacillin.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 719719Penicillin-binding protein 1APRO_0000083183Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi171101.spr0329.

Structurei

Secondary structure

1
719
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi54 – 563Combined sources
Beta strandi62 – 654Combined sources
Helixi270 – 2723Combined sources
Helixi273 – 28715Combined sources
Turni291 – 2933Combined sources
Beta strandi296 – 3005Combined sources
Helixi304 – 31512Combined sources
Beta strandi317 – 3193Combined sources
Beta strandi323 – 3253Combined sources
Beta strandi328 – 3358Combined sources
Turni336 – 3383Combined sources
Beta strandi340 – 3456Combined sources
Turni360 – 3623Combined sources
Helixi369 – 3713Combined sources
Helixi372 – 3765Combined sources
Helixi378 – 3836Combined sources
Beta strandi388 – 3914Combined sources
Beta strandi393 – 3986Combined sources
Beta strandi417 – 4204Combined sources
Helixi421 – 4266Combined sources
Helixi430 – 44011Combined sources
Helixi442 – 4509Combined sources
Turni451 – 4533Combined sources
Helixi461 – 4644Combined sources
Beta strandi474 – 4774Combined sources
Helixi480 – 49112Combined sources
Beta strandi494 – 4974Combined sources
Beta strandi500 – 5078Combined sources
Beta strandi512 – 5143Combined sources
Beta strandi519 – 5213Combined sources
Helixi525 – 54117Combined sources
Helixi545 – 5473Combined sources
Beta strandi555 – 5606Combined sources
Helixi565 – 5706Combined sources
Beta strandi578 – 5803Combined sources
Beta strandi582 – 5876Combined sources
Beta strandi589 – 59810Combined sources
Helixi608 – 6125Combined sources
Helixi613 – 62614Combined sources
Beta strandi627 – 6293Combined sources
Beta strandi640 – 6434Combined sources
Beta strandi646 – 6494Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2C5WX-ray2.55A51-66[»]
B266-650[»]
2C6WX-ray2.61A51-66[»]
B267-650[»]
2V2FX-ray1.90A47-70[»]
2ZC5X-ray3.00A/C47-70[»]
2ZC6X-ray2.70A/C47-70[»]
ProteinModelPortaliQ8DR59.
SMRiQ8DR59. Positions 266-650.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8DR59.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi654 – 69138Ser-richAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the glycosyltransferase 51 family.Curated
In the C-terminal section; belongs to the transpeptidase family.Curated

Phylogenomic databases

eggNOGiENOG4105BZ4. Bacteria.
COG0744. LUCA.
HOGENOMiHOG000041140.
KOiK05366.
OMAiGINQAVE.
OrthoDBiEOG6CGCKC.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR001264. Glyco_trans_51.
IPR023346. Lysozyme-like_dom.
IPR001460. PCN-bd_Tpept.
[Graphical view]
PfamiPF00912. Transgly. 1 hit.
PF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
SSF56601. SSF56601. 2 hits.

Sequencei

Sequence statusi: Complete.

Q8DR59-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKPTILRLI KYLSISFLSL VIAAIVLGGG VFFYYVSKAP SLSESKLVAT
60 70 80 90 100
TSSKIYDNKN QLIADLGSER RVNAQANDIP TDLVKAIVSI EDHRFFDHRG
110 120 130 140 150
IDTIRILGAF LRNLQSNSLQ GGSALTQQLI KLTYFSTSTS DQTISRKAQE
160 170 180 190 200
AWLAIQLEQK ATKQEILTYY INKVYMSNGN YGMQTAAQNY YGKDLNNLSL
210 220 230 240 250
PQLALLAGMP QAPNQYDPYS HPEAAQDRRN LVLSEMKNQG YISAEQYEKA
260 270 280 290 300
VNTPITDGLQ SLKSASNYPA YMDNYLKEVI NQVEEETGYN LLTTGMDVYT
310 320 330 340 350
NVDQEAQKHL WDIYNTDEYV AYPDDELQVA STIVDVSNGK VIAQLGARHQ
360 370 380 390 400
SSNVSFGINQ AVETNRDWGS TMKPITDYAP ALEYGVYEST ATIVHDEPYN
410 420 430 440 450
YPGTNTPVYN WDRGYFGNIT LQYALQQSRN VPAVETLNKV GLNRAKTFLN
460 470 480 490 500
GLGIDYPSIH YSNAISSNTT ESDKKYGASS EKMAAAYAAF ANGGTYYKPM
510 520 530 540 550
YIHKVVFSDG SEKEFSNVGT RAMKETTAYM MTDMMKTVLS YGTGRNAYLA
560 570 580 590 600
WLPQAGKTGT SNYTDEEIEN HIKTSQFVAP DELFAGYTRK YSMAVWTGYS
610 620 630 640 650
NRLTPLVGNG LTVAAKVYRS MMTYLSEGSN PEDWNIPEGL YRNGEFVFKN
660 670 680 690 700
GARSTWSSPA PQQPPSTESS SSSSDSSTSQ SSSTTPSTNN STTTNPNNNT
710
QQSNTTPDQQ NQNPQPAQP
Length:719
Mass (Da):79,701
Last modified:March 1, 2003 - v1
Checksum:i14537A7070799EE6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M90527 Genomic DNA. Translation: AAA26956.1.
AE007317 Genomic DNA. Translation: AAK99133.1.
PIRiA42893.
A97913.
RefSeqiNP_357923.1. NC_003098.1.
WP_001039991.1. NC_003098.1.

Genome annotation databases

EnsemblBacteriaiAAK99133; AAK99133; spr0329.
GeneIDi934791.
KEGGispr:spr0329.
PATRICi19700493. VBIStrPne107296_0368.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M90527 Genomic DNA. Translation: AAA26956.1.
AE007317 Genomic DNA. Translation: AAK99133.1.
PIRiA42893.
A97913.
RefSeqiNP_357923.1. NC_003098.1.
WP_001039991.1. NC_003098.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2C5WX-ray2.55A51-66[»]
B266-650[»]
2C6WX-ray2.61A51-66[»]
B267-650[»]
2V2FX-ray1.90A47-70[»]
2ZC5X-ray3.00A/C47-70[»]
2ZC6X-ray2.70A/C47-70[»]
ProteinModelPortaliQ8DR59.
SMRiQ8DR59. Positions 266-650.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi171101.spr0329.

Chemistry

DrugBankiDB00415. Ampicillin.
DB08795. Azidocillin.
DB01140. Cefadroxil.
DB00456. Cefalotin.
DB00493. Cefotaxime.
DB01331. Cefoxitin.
DB00438. Ceftazidime.
DB00567. Cephalexin.
DB01000. Cyclacillin.
DB00485. Dicloxacillin.
DB00739. Hetacillin.
DB01603. Meticillin.
DB00607. Nafcillin.
DB00713. Oxacillin.

Protein family/group databases

CAZyiGT51. Glycosyltransferase Family 51.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK99133; AAK99133; spr0329.
GeneIDi934791.
KEGGispr:spr0329.
PATRICi19700493. VBIStrPne107296_0368.

Phylogenomic databases

eggNOGiENOG4105BZ4. Bacteria.
COG0744. LUCA.
HOGENOMiHOG000041140.
KOiK05366.
OMAiGINQAVE.
OrthoDBiEOG6CGCKC.

Enzyme and pathway databases

UniPathwayiUPA00219.
BioCyciSPNE171101:GJC8-336-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ8DR59.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR001264. Glyco_trans_51.
IPR023346. Lysozyme-like_dom.
IPR001460. PCN-bd_Tpept.
[Graphical view]
PfamiPF00912. Transgly. 1 hit.
PF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
SSF56601. SSF56601. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequences of genes encoding penicillin-binding proteins from Streptococcus pneumoniae and Streptococcus oralis with high homology to Escherichia coli penicillin-binding proteins 1a and 1b."
    Martin C., Briese T., Hakenbeck R.
    J. Bacteriol. 174:4517-4523(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-255 / R6.
  3. "Genetic identification of exported proteins in Streptococcus pneumoniae."
    Pearce B.J., Yin Y.B., Masure H.R.
    Mol. Microbiol. 9:1037-1050(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 293-369.
    Strain: R6X.

Entry informationi

Entry nameiPBPA_STRR6
AccessioniPrimary (citable) accession number: Q8DR59
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: March 1, 2003
Last modified: December 9, 2015
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.