Q8DR49 (Q8DR49_STRR6) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Phosphomevalonate kinase EMBL AAK99144.1

Gene names

Name:	mvaK2 EMBL AAK99144.1
Ordered Locus Names:	spr0340

Organism

Streptococcus pneumoniae (strain ATCC BAA-255 / R6)

Taxonomic identifier

171101 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	335 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Ligand	ATP-binding RuleBase RU003563 Nucleotide-binding
Molecular function	Kinase RuleBase RU003563 EMBL AAK99144.1 Transferase
Technical term	3D-structure PDB 3GON PDB 1K47 Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8DR49 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: B37D78CE13EED02E	FASTA	335	37,026
	10 20 30 40 50 60 MIAVKTCGKL YWAGEYAILE PGQLALIKDI PIYMRAEIAF SDSYRIYSDM FDFAVDLRPN 70 80 90 100 110 120 PDYSLIQETI ALMGDFLAVR GQNLRPFSLA IYGKMEREGK KFGLGSSGSV VVLVVKALLA 130 140 150 160 170 180 LYNLSVDQNL LFKLTSAVLL KRGDNGSMGD LACIAAEDLV LYQSFDRQKV AAWLEEENLA 190 200 210 220 230 240 TVLERDWGFS ISQVKPTLEC DFLVGWTKEV AVSSHMVQQI KQNINQNFLT SSKETVVSLV 250 260 270 280 290 300 EALEQGKSEK IIEQVEVASK LLEGLSTDIY TPLLRQLKEA SQDLQAVAKS SGAGGGDCGI 310 320 330 ALSFDAQSTK TLKNRWADLG IELLYQERIG HDDKS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome of the bacterium Streptococcus pneumoniae strain R6." Hoskins J., Alborn W.E. Jr., Arnold J., Blaszczak L.C., Burgett S., DeHoff B.S., Estrem S.T., Fritz L., Fu D.-J., Fuller W., Geringer C., Gilmour R., Glass J.S., Khoja H., Kraft A.R., Lagace R.E., LeBlanc D.J., Lee L.N. , Lefkowitz E.J., Lu J., Matsushima P., McAhren S.M., McHenney M., McLeaster K., Mundy C.W., Nicas T.I., Norris F.H., O'Gara M., Peery R.B., Robertson G.T., Rockey P., Sun P.-M., Winkler M.E., Yang Y., Young-Bellido M., Zhao G., Zook C.A., Baltz R.H., Jaskunas S.R., Rosteck P.R. Jr., Skatrud P.L., Glass J.I. J. Bacteriol. 183:5709-5717(2001) [PubMed: 11544234] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-255 / R6.
[2]	"Crystal structure of the Streptococcus pneumoniae phosphomevalonate kinase, a member of the GHMP kinase superfamily." Romanowski M.J., Bonanno J.B., Burley S.K. Proteins 47:568-571(2002) [PubMed: 12001237] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.42 ANGSTROMS).
[3]	"Structure of the ternary complex of phosphomevalonate kinase: the enzyme and its family." Andreassi J.L., Vetting M.W., Bilder P.W., Roderick S.L., Leyh T.S. Biochemistry 48:6461-6468(2009) [PubMed: 19485344] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE007317 Genomic DNA. Translation: AAK99144.1.

PIR

D97914.

RefSeq

NP_357934.1. NC_003098.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1K47	X-ray	2.42	A/B/C/D/E/F	1-335	[»]
3GON	X-ray	1.90	A	1-335	[»]

ProteinModelPortal

Q8DR49.

SMR

Q8DR49. Positions 1-329.

ModBase

Search...

Protein-protein interaction databases

STRING

Q8DR49.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

EBSTRT00000015984; EBSTRP00000015380; EBSTRG00000015984.

GeneID

934823.

GenomeReviews

Gene locus spr0340 in contig AE007317_GR.

KEGG

spr:spr0340.

PATRIC

19700517. VBIStrPne107296_0380.

Phylogenomic databases

eggNOG

COG1577.

GeneTree

EBGT00050000027443.

HOGENOM

HBG697370.

OMA

YGGWIAY.

ProtClustDB

CLSK877122.

Enzyme and pathway databases

BioCyc

SPNE171101:SPR0340-MONOMER.

Family and domain databases

InterPro

IPR006204. GHMP_kinase.
IPR013750. GHMP_kinase_C.
IPR005917. Pmev_kin_Gpos.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]

Gene3D

G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.

KO

K00938.

Pfam

PF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]

SUPFAM

SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.

TIGRFAMs

TIGR01220. Pmev_kin_Gr_pos. 1 hit.

ProtoNet

Search...

Entry information

Entry name

Q8DR49_STRR6

Accession

Primary (citable) accession number: Q8DR49

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2003
Last sequence update:	March 1, 2003
Last modified:	December 14, 2011
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)