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Q8DQZ1 (LACG1_STRR6) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
6-phospho-beta-galactosidase 1
EC=3.2.1.85
Alternative name(s):
Beta-D-phosphogalactoside galactohydrolase 1
Short name=PGALase 1
P-beta-Gal 1
Short name=PBG 1
Gene names
Name:lacG1
Ordered Locus Names:spr0424
OrganismStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Taxonomic identifier171101 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length470 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

A 6-phospho-beta-D-galactoside + H2O = 6-phospho-D-galactose + an alcohol. HAMAP MF_01574

Pathway

Carbohydrate metabolism; lactose degradation; D-galactose 6-phosphate and beta-D-glucose from lactose 6-phosphate: step 1/1. HAMAP MF_01574

Sequence similarities

Belongs to the glycosyl hydrolase 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4704706-phospho-beta-galactosidase 1 HAMAP MF_01574
PRO_0000260732

Sites

Active site1641Proton donor By similarity
Active site3781Nucleophile By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8DQZ1 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: CAE61D8921067D6D

FASTA47054,675
        10         20         30         40         50         60 
MENLQVKALP KEFLLGTATA AYQVEGATRV DGKGINMWDV YLQENSPFLP DPASDFYYRY 

        70         80         90        100        110        120 
EEDIALAAEH GLQALRLSIS WVRIFPDIDG DANVLAVHYY HRVFQSCLKH NVIPFVSLHH 

       130        140        150        160        170        180 
FDSPQKMLET GDWLNRENID RFIRYARFCF QEFTEVKHWF TINELMSLAA GQYIGGQFPP 

       190        200        210        220        230        240 
NHHFQLSEAI QANHNMLLAH ALAVLEFHQL GIEGKVGCIH ALKPGYPIDG QKENILAAKR 

       250        260        270        280        290        300 
YDVYNNKFLL DGTFLGYYSE DTLFHLNQIL EANNSSFIIE DGDLEIMKRA APLNTMFVMN 

       310        320        330        340        350        360 
YYRSEFIREY KGENRQEFNS TGIKGQSSFK LNALGEFVKK PGIPTTDWDW NIYPQGLFDM 

       370        380        390        400        410        420 
LLRIKEEYPQ HPVIYLTENG TALKEVKPEG ENDIIDDSKR IRYIEQHLHK VLEARDRGVN 

       430        440        450        460        470 
IQGYFIWSLQ DQFSWANGYN KRYGLFFVDY ETQKRYIKKS ALWVKGLKRN

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE007317 Genomic DNA. Translation: AAK99228.1.
PIRH97924.
RefSeqNP_358018.1. NC_003098.1.

3D structure databases

HSSPHSSP built from PDB template 1PBG based on UniProtKB P11546.
ProteinModelPortalQ8DQZ1.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ8DQZ1.

Protein family/group databases

CAZyGH1. Glycoside Hydrolase Family 1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBSTRT00000015780; EBSTRP00000015176; EBSTRG00000015780.
GeneID934741.
GenomeReviewsGene locus spr0424 in contig AE007317_GR.
KEGGspr:spr0424.
PATRIC19700689. VBIStrPne107296_0466.

Phylogenomic databases

eggNOGCOG2723.
GeneTreeEBGT00050000027409.
HOGENOMHBG316462.
OMATEATNDY.
PhylomeDBQ8DQZ1.
ProtClustDBPRK13511.

Enzyme and pathway databases

BioCycSPNE171101:SPR0424-MONOMER.

Family and domain databases

HAMAPMF_01574. LacG.
[Tree]
InterProIPR005928. 6P-beta-galactosidase.
IPR001360. Glyco_hydro_1.
IPR013781. Glyco_hydro_subgr_catalytic.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
Gene3DG3DSA:3.20.20.80. Glyco_hydro_cat. 1 hit.
KOK01220.
PANTHERPTHR10353. Glyco_hydro_1. 1 hit.
PfamPF00232. Glyco_hydro_1. 1 hit.
[Graphical view]
PRINTSPR00131. GLHYDRLASE1.
SUPFAMSSF51445. Glyco_hydro_cat. 1 hit.
TIGRFAMsTIGR01233. LacG. 1 hit.
PROSITEPS00572. GLYCOSYL_HYDROL_F1_1. False negative.
PS00653. GLYCOSYL_HYDROL_F1_2. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLACG1_STRR6
AccessionPrimary (citable) accession number: Q8DQZ1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: March 1, 2003
Last modified: January 25, 2012
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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