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Protein

6-phospho-beta-galactosidase 1

Gene

lacG1

Organism
Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

A 6-phospho-beta-D-galactoside + H2O = 6-phospho-D-galactose + an alcohol.UniRule annotation

Pathwayi: lactose degradation

This protein is involved in step 1 of the subpathway that synthesizes D-galactose 6-phosphate and beta-D-glucose from lactose 6-phosphate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. 6-phospho-beta-galactosidase 2 (lacG2), 6-phospho-beta-galactosidase 1 (lacG1)
This subpathway is part of the pathway lactose degradation, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-galactose 6-phosphate and beta-D-glucose from lactose 6-phosphate, the pathway lactose degradation and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei164Proton donorUniRule annotation1
Active sitei378NucleophileUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase

Enzyme and pathway databases

BioCyciSPNE171101:G1FZH-441-MONOMER
UniPathwayiUPA00542; UER00605

Protein family/group databases

CAZyiGH1 Glycoside Hydrolase Family 1

Names & Taxonomyi

Protein namesi
Recommended name:
6-phospho-beta-galactosidase 1UniRule annotation (EC:3.2.1.85UniRule annotation)
Alternative name(s):
Beta-D-phosphogalactoside galactohydrolase 1UniRule annotation
Short name:
PGALase 1UniRule annotation
P-beta-Gal 1UniRule annotation
Short name:
PBG 1UniRule annotation
Gene namesi
Name:lacG1UniRule annotation
Ordered Locus Names:spr0424
OrganismiStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Taxonomic identifieri171101 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000000586 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002607321 – 4706-phospho-beta-galactosidase 1Add BLAST470

Proteomic databases

PRIDEiQ8DQZ1

Interactioni

Protein-protein interaction databases

STRINGi171101.spr0424

Structurei

3D structure databases

ProteinModelPortaliQ8DQZ1
SMRiQ8DQZ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 1 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CS2 Bacteria
COG2723 LUCA
HOGENOMiHOG000088632
KOiK01220
OMAiNRWWLDP

Family and domain databases

HAMAPiMF_01574 LacG, 1 hit
InterProiView protein in InterPro
IPR005928 6P-beta-galactosidase
IPR001360 Glyco_hydro_1
IPR017853 Glycoside_hydrolase_SF
PANTHERiPTHR10353 PTHR10353, 1 hit
PfamiView protein in Pfam
PF00232 Glyco_hydro_1, 1 hit
PRINTSiPR00131 GLHYDRLASE1
SUPFAMiSSF51445 SSF51445, 1 hit
TIGRFAMsiTIGR01233 lacG, 1 hit

Sequencei

Sequence statusi: Complete.

Q8DQZ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENLQVKALP KEFLLGTATA AYQVEGATRV DGKGINMWDV YLQENSPFLP
60 70 80 90 100
DPASDFYYRY EEDIALAAEH GLQALRLSIS WVRIFPDIDG DANVLAVHYY
110 120 130 140 150
HRVFQSCLKH NVIPFVSLHH FDSPQKMLET GDWLNRENID RFIRYARFCF
160 170 180 190 200
QEFTEVKHWF TINELMSLAA GQYIGGQFPP NHHFQLSEAI QANHNMLLAH
210 220 230 240 250
ALAVLEFHQL GIEGKVGCIH ALKPGYPIDG QKENILAAKR YDVYNNKFLL
260 270 280 290 300
DGTFLGYYSE DTLFHLNQIL EANNSSFIIE DGDLEIMKRA APLNTMFVMN
310 320 330 340 350
YYRSEFIREY KGENRQEFNS TGIKGQSSFK LNALGEFVKK PGIPTTDWDW
360 370 380 390 400
NIYPQGLFDM LLRIKEEYPQ HPVIYLTENG TALKEVKPEG ENDIIDDSKR
410 420 430 440 450
IRYIEQHLHK VLEARDRGVN IQGYFIWSLQ DQFSWANGYN KRYGLFFVDY
460 470
ETQKRYIKKS ALWVKGLKRN
Length:470
Mass (Da):54,675
Last modified:March 1, 2003 - v1
Checksum:iCAE61D8921067D6D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE007317 Genomic DNA Translation: AAK99228.1
PIRiH97924
RefSeqiNP_358018.1, NC_003098.1
WP_000429432.1, NC_003098.1

Genome annotation databases

EnsemblBacteriaiAAK99228; AAK99228; spr0424
GeneIDi934741
KEGGispr:spr0424
PATRICifig|171101.6.peg.466

Similar proteinsi

Entry informationi

Entry nameiLACG1_STRR6
AccessioniPrimary (citable) accession number: Q8DQZ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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