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Q8DQK5

- THIM1_STRR6

UniProt

Q8DQK5 - THIM1_STRR6

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Protein

Hydroxyethylthiazole kinase 1

Gene

thiM1

Organism
Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).UniRule annotation

Catalytic activityi

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.UniRule annotation

Cofactori

Magnesium.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei39 – 391Substrate; via amide nitrogenUniRule annotation
Binding sitei115 – 1151ATPUniRule annotation
Binding sitei160 – 1601ATPUniRule annotation
Binding sitei187 – 1871Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. hydroxyethylthiazole kinase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. thiamine biosynthetic process Source: UniProtKB-KW
  2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Thiamine biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSPNE171101:GJC8-636-MONOMER.
UniPathwayiUPA00060; UER00139.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxyethylthiazole kinase 1UniRule annotation (EC:2.7.1.50UniRule annotation)
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase 1UniRule annotation
Short name:
TH kinase 1UniRule annotation
Short name:
Thz kinase 1UniRule annotation
Gene namesi
Name:thiM1UniRule annotation
Ordered Locus Names:spr0629
OrganismiStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Taxonomic identifieri171101 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000586: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 260260Hydroxyethylthiazole kinase 1PRO_0000156964Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi171101.spr0629.

Structurei

3D structure databases

ProteinModelPortaliQ8DQK5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Thz kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2145.
HOGENOMiHOG000114352.
KOiK00878.
OrthoDBiEOG628F8M.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
HAMAPiMF_00228. Thz_kinase.
InterProiIPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamiPF02110. HK. 1 hit.
[Graphical view]
PIRSFiPIRSF000513. Thz_kinase. 1 hit.
PRINTSiPR01099. HYETHTZKNASE.
SUPFAMiSSF53613. SSF53613. 1 hit.
TIGRFAMsiTIGR00694. thiM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8DQK5 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTSLKLLKEK APLVICITND VVKNFTANGL VALGASPAMS EFPADLEDLL
60 70 80 90 100
KYAGGLLINI GTLTDENWKL YQAALKIAEK YNVPAVLDPV ACGAGEYRKK
110 120 130 140 150
VADDLINNYK LAAIRGNAGE IASLVGIDVA SKGVDSAGVD NIDEIALAAN
160 170 180 190 200
EKFNIPIVVT GEVDAIAVNG EVVTIHNGSA MMPKVIGTGC LLGAVVASFI
210 220 230 240 250
GLEKGQELKS LETAMLVYNI AGEMAEKRPN GHLPGTFKVE FINALYEITD
260
EDVKEFKRVK
Length:260
Mass (Da):27,607
Last modified:May 24, 2004 - v2
Checksum:iCC3C8551E68049B8
GO

Sequence cautioni

The sequence AAK99433.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE007317 Genomic DNA. Translation: AAK99433.1. Different initiation.
PIRiE97950.
RefSeqiNP_358223.1. NC_003098.1.

Genome annotation databases

EnsemblBacteriaiAAK99433; AAK99433; spr0629.
GeneIDi934546.
KEGGispr:spr0629.
PATRICi19701155. VBIStrPne107296_0700.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE007317 Genomic DNA. Translation: AAK99433.1 . Different initiation.
PIRi E97950.
RefSeqi NP_358223.1. NC_003098.1.

3D structure databases

ProteinModelPortali Q8DQK5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 171101.spr0629.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK99433 ; AAK99433 ; spr0629 .
GeneIDi 934546.
KEGGi spr:spr0629.
PATRICi 19701155. VBIStrPne107296_0700.

Phylogenomic databases

eggNOGi COG2145.
HOGENOMi HOG000114352.
KOi K00878.
OrthoDBi EOG628F8M.

Enzyme and pathway databases

UniPathwayi UPA00060 ; UER00139 .
BioCyci SPNE171101:GJC8-636-MONOMER.

Family and domain databases

Gene3Di 3.40.1190.20. 1 hit.
HAMAPi MF_00228. Thz_kinase.
InterProi IPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view ]
Pfami PF02110. HK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000513. Thz_kinase. 1 hit.
PRINTSi PR01099. HYETHTZKNASE.
SUPFAMi SSF53613. SSF53613. 1 hit.
TIGRFAMsi TIGR00694. thiM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-255 / R6.

Entry informationi

Entry nameiTHIM1_STRR6
AccessioniPrimary (citable) accession number: Q8DQK5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: October 1, 2014
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3