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Q8DQK5 (THIM1_STRR6) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxyethylthiazole kinase 1

EC=2.7.1.50
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase 1
Short name=TH kinase 1
Short name=Thz kinase 1
Gene names
Name:thiM1
Ordered Locus Names:spr0629
OrganismStreptococcus pneumoniae (strain ATCC BAA-255 / R6) [Reference proteome] [HAMAP]
Taxonomic identifier171101 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length260 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole. HAMAP-Rule MF_00228

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00228

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1. HAMAP-Rule MF_00228

Sequence similarities

Belongs to the Thz kinase family.

Sequence caution

The sequence AAK99433.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 260260Hydroxyethylthiazole kinase 1 HAMAP-Rule MF_00228
PRO_0000156964

Sites

Binding site391Substrate; via amide nitrogen By similarity
Binding site1151ATP By similarity
Binding site1601ATP By similarity
Binding site1871Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8DQK5 [UniParc].

Last modified May 24, 2004. Version 2.
Checksum: CC3C8551E68049B8

FASTA26027,607
        10         20         30         40         50         60 
MTSLKLLKEK APLVICITND VVKNFTANGL VALGASPAMS EFPADLEDLL KYAGGLLINI 

        70         80         90        100        110        120 
GTLTDENWKL YQAALKIAEK YNVPAVLDPV ACGAGEYRKK VADDLINNYK LAAIRGNAGE 

       130        140        150        160        170        180 
IASLVGIDVA SKGVDSAGVD NIDEIALAAN EKFNIPIVVT GEVDAIAVNG EVVTIHNGSA 

       190        200        210        220        230        240 
MMPKVIGTGC LLGAVVASFI GLEKGQELKS LETAMLVYNI AGEMAEKRPN GHLPGTFKVE 

       250        260 
FINALYEITD EDVKEFKRVK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE007317 Genomic DNA. Translation: AAK99433.1. Different initiation.
PIRE97950.
RefSeqNP_358223.1. NC_003098.1.

3D structure databases

ProteinModelPortalQ8DQK5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING171101.spr0629.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK99433; AAK99433; spr0629.
GeneID934546.
KEGGspr:spr0629.
PATRIC19701155. VBIStrPne107296_0700.

Phylogenomic databases

eggNOGCOG2145.
HOGENOMHOG000114352.
KOK00878.
OrthoDBEOG628F8M.

Enzyme and pathway databases

BioCycSPNE171101:GJC8-636-MONOMER.
UniPathwayUPA00060; UER00139.

Family and domain databases

Gene3D3.40.1190.20. 1 hit.
HAMAPMF_00228. Thz_kinase.
InterProIPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamPF02110. HK. 1 hit.
[Graphical view]
PIRSFPIRSF000513. Thz_kinase. 1 hit.
PRINTSPR01099. HYETHTZKNASE.
SUPFAMSSF53613. SSF53613. 1 hit.
TIGRFAMsTIGR00694. thiM. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTHIM1_STRR6
AccessionPrimary (citable) accession number: Q8DQK5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: June 11, 2014
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways