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Q8DQJ9

- THIM2_STRR6

UniProt

Q8DQJ9 - THIM2_STRR6

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Protein
Hydroxyethylthiazole kinase 2
Gene
thiM2, spr0636
Organism
Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei41 – 411Substrate; via amide nitrogen By similarity
Binding sitei116 – 1161ATP By similarity
Binding sitei166 – 1661ATP By similarity
Binding sitei193 – 1931Substrate; via amide nitrogen By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. hydroxyethylthiazole kinase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. thiamine biosynthetic process Source: UniProtKB-KW
  2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Thiamine biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSPNE171101:GJC8-643-MONOMER.
UniPathwayiUPA00060; UER00139.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxyethylthiazole kinase 2 (EC:2.7.1.50)
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase 2
Short name:
TH kinase 2
Short name:
Thz kinase 2
Gene namesi
Name:thiM2
Ordered Locus Names:spr0636
OrganismiStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Taxonomic identifieri171101 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000586: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 267267Hydroxyethylthiazole kinase 2UniRule annotation
PRO_0000383899Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi171101.spr0636.

Structurei

3D structure databases

ProteinModelPortaliQ8DQJ9.

Family & Domainsi

Sequence similaritiesi

Belongs to the Thz kinase family.

Phylogenomic databases

eggNOGiCOG2145.
HOGENOMiHOG000114352.
KOiK00878.
OMAiAKPIMAE.
OrthoDBiEOG628F8M.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
HAMAPiMF_00228. Thz_kinase.
InterProiIPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamiPF02110. HK. 1 hit.
[Graphical view]
PIRSFiPIRSF000513. Thz_kinase. 1 hit.
PRINTSiPR01099. HYETHTZKNASE.
SUPFAMiSSF53613. SSF53613. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8DQJ9-1 [UniParc]FASTAAdd to Basket

« Hide

MQEFTNPFPI GSSSLIHCIT NEISCEMLAN GILALGCKPV MADDSREVLD    50
FTKQSQALFI NLGHLSAEKE KAIRMAASYA NQSSLPMVVD AVGVTTSSIR 100
KSLVKDLLDY RPTVLKGNMS EIRSLVGLKH HGVGVDASAK DQETEDLLQV 150
LKDWCQTYPG MSFLVTGPKD LVVSKNQVAV LGNGCTELDW ITGTGDLVGA 200
LTAVFLSQGK TGFEASCLAV SYLNIAAEKI VVQGMGLEEF RYQVLNQLSL 250
LRRDENWLDT IKGEVYE 267
Length:267
Mass (Da):29,081
Last modified:March 1, 2003 - v1
Checksum:i70B2FBA10D231FA1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE007317 Genomic DNA. Translation: AAK99440.1.
PIRiD97951.
H95083.
RefSeqiNP_358230.1. NC_003098.1.

Genome annotation databases

EnsemblBacteriaiAAK99440; AAK99440; spr0636.
GeneIDi934435.
KEGGispr:spr0636.
PATRICi19701169. VBIStrPne107296_0707.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE007317 Genomic DNA. Translation: AAK99440.1 .
PIRi D97951.
H95083.
RefSeqi NP_358230.1. NC_003098.1.

3D structure databases

ProteinModelPortali Q8DQJ9.
ModBasei Search...

Protein-protein interaction databases

STRINGi 171101.spr0636.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK99440 ; AAK99440 ; spr0636 .
GeneIDi 934435.
KEGGi spr:spr0636.
PATRICi 19701169. VBIStrPne107296_0707.

Phylogenomic databases

eggNOGi COG2145.
HOGENOMi HOG000114352.
KOi K00878.
OMAi AKPIMAE.
OrthoDBi EOG628F8M.

Enzyme and pathway databases

UniPathwayi UPA00060 ; UER00139 .
BioCyci SPNE171101:GJC8-643-MONOMER.

Family and domain databases

Gene3Di 3.40.1190.20. 1 hit.
HAMAPi MF_00228. Thz_kinase.
InterProi IPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view ]
Pfami PF02110. HK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000513. Thz_kinase. 1 hit.
PRINTSi PR01099. HYETHTZKNASE.
SUPFAMi SSF53613. SSF53613. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-255 / R6.

Entry informationi

Entry nameiTHIM2_STRR6
AccessioniPrimary (citable) accession number: Q8DQJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: March 1, 2003
Last modified: June 11, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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