UniProtKB - Q8DQB5 (Q8DQB5_STRR6)
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Protein
DNA topoisomerase 4 subunit B
Gene
parE
Organism
Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Status
Functioni
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.UniRule annotation
Catalytic activityi
ATP-dependent breakage, passage and rejoining of double-stranded DNA.UniRule annotationSAAS annotation
Cofactori
Mg2+SAAS annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 11 | ATPUniRule annotation | 1 | |
Binding sitei | 51 | ATPUniRule annotation | 1 | |
Binding sitei | 78 | ATPUniRule annotation | 1 | |
Binding sitei | 344 | ATPUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 118 – 124 | ATPUniRule annotation | 7 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- DNA binding Source: UniProtKB-UniRule
- DNA topoisomerase type II (ATP-hydrolyzing) activity Source: GO_Central
GO - Biological processi
- chromosome segregation Source: GO_Central
- DNA topological change Source: GO_Central
Keywordsi
Molecular function | DNA-bindingUniRule annotation, Isomerase, TopoisomeraseUniRule annotation |
Ligand | ATP-bindingUniRule annotation, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | SPNE171101:G1FZH-796-MONOMER. |
Names & Taxonomyi
Protein namesi | Recommended name: DNA topoisomerase 4 subunit BUniRule annotation (EC:5.99.1.3UniRule annotation)Alternative name(s): Topoisomerase IV subunit BUniRule annotation |
Gene namesi | Name:parEUniRule annotationImported Ordered Locus Names:spr0756Imported |
Organismi | Streptococcus pneumoniae (strain ATCC BAA-255 / R6)Imported |
Taxonomic identifieri | 171101 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus › |
Proteomesi |
|
Subcellular locationi
GO - Cellular componenti
- chromosome Source: InterPro
- nucleoid Source: GO_Central
Interactioni
Subunit structurei
Heterotetramer composed of ParC and ParE.UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 461 | Interaction with DNAUniRule annotation | 1 | |
Sitei | 513 | Interaction with DNAUniRule annotation | 1 | |
Sitei | 629 | Interaction with DNAUniRule annotation | 1 |
Protein-protein interaction databases
STRINGi | 171101.spr0756. |
Structurei
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4LP0 | X-ray | 1.95 | A | 1-226 | [»] | |
4LPB | X-ray | 1.75 | A | 1-226 | [»] | |
4MOT | X-ray | 1.75 | A | 1-226 | [»] | |
5BOC | X-ray | 2.20 | A | 1-226 | [»] | |
5BOD | X-ray | 2.20 | A | 1-226 | [»] | |
ProteinModelPortali | Q8DQB5. | |||||
SMRi | Q8DQB5. | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 427 – 541 | ToprimInterPro annotationAdd BLAST | 115 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | ENOG4105C7D. Bacteria. COG0187. LUCA. |
HOGENOMi | HOG000075154. |
KOi | K02622. |
OMAi | KIAYAWT. |
Family and domain databases
CDDi | cd00075. HATPase_c. 1 hit. |
Gene3Di | 3.30.230.10. 1 hit. 3.30.565.10. 1 hit. 3.40.50.670. 1 hit. |
HAMAPi | MF_00939. ParE_type2. 1 hit. |
InterProi | View protein in InterPro IPR002288. DNA_gyrase_B_C. IPR003594. HATPase_C. IPR036890. HATPase_C_sf. IPR005740. ParE_type2. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. IPR001241. Topo_IIA. IPR013760. Topo_IIA-like_dom_sf. IPR013759. Topo_IIA_B_C. IPR013506. Topo_IIA_bsu_dom2. IPR018522. TopoIIA_CS. IPR006171. TOPRIM_domain. |
PANTHERi | PTHR10169. PTHR10169. 1 hit. PTHR10169:SF44. PTHR10169:SF44. 1 hit. |
Pfami | View protein in Pfam PF00204. DNA_gyraseB. 1 hit. PF00986. DNA_gyraseB_C. 1 hit. PF02518. HATPase_c. 1 hit. PF01751. Toprim. 1 hit. |
SMARTi | View protein in SMART SM00387. HATPase_c. 1 hit. SM00433. TOP2c. 1 hit. |
SUPFAMi | SSF54211. SSF54211. 1 hit. SSF55874. SSF55874. 1 hit. SSF56719. SSF56719. 1 hit. |
TIGRFAMsi | TIGR01058. parE_Gpos. 1 hit. |
PROSITEi | View protein in PROSITE PS00177. TOPOISOMERASE_II. 1 hit. PS50880. TOPRIM. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q8DQB5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSKKEININN YNDDAIQVLE GLDAVRKRPG MYIGSTDGAG LHHLVWEIVD
60 70 80 90 100
NAVDEALSGF GDRIDVTINK DGSLTVQDHG RGMPTGMHAM GIPTVEVIFT
110 120 130 140 150
ILHAGGKFGQ GGYKTSGGLH GVGSSVVNAL SSWLEVEITR DGAVYKQRFE
160 170 180 190 200
NGGKPVTTLK KIGTALKSKT GTKVTFMPDA TIFSTTDFKY NTISERLNES
210 220 230 240 250
AFLLKNVTLS LTDKRTDEAI EFHYENGVQD FVSYLNEDKE ILTPVLYFEG
260 270 280 290 300
EDNGFQVEVA LQYNDGFSDN ILSFVNNVRT KDGGTHETGL KSAITKVMND
310 320 330 340 350
YARKTGLLKE KDKNLEGSDY REGLAAVLSI LVPEEHLQFE GQTKDKLGSP
360 370 380 390 400
LARPVVDGIV ADKLTFFLME NGELASNLIR KAIKARDARE AARKARDESR
410 420 430 440 450
NGKKNKKDKG LLSGKLTPAQ SKNPAKNELY LVEGDSAGGS AKQGRDRKFQ
460 470 480 490 500
AILPLRGKVI NTAKAKMADI LKNEEINTMI YTIGAGVGAD FSIEDANYDK
510 520 530 540 550
IIIMTDADTD GAHIQTLLLT FFYRYMRPLV EAGHVYIALP PLYKMSKGKG
560 570 580 590 600
KKEEVAYAWT DGELEELRKQ FGKGATLQRY KGLGEMNADQ LWETTMNPET
610 620 630 640
RTLIRVTIED LARAERRVNV LMGDKVEPRR KWIEDNVKFT LEEATVF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE007317 Genomic DNA. Translation: AAK99560.1. |
PIRi | D97966. |
RefSeqi | NP_358350.1. NC_003098.1. WP_000037270.1. NC_003098.1. |
Genome annotation databases
EnsemblBacteriai | AAK99560; AAK99560; spr0756. |
GeneIDi | 934298. |
KEGGi | spr:spr0756. |
PATRICi | fig|171101.6.peg.836. |
Similar proteinsi
Entry informationi
Entry namei | Q8DQB5_STRR6 | |
Accessioni | Q8DQB5Primary (citable) accession number: Q8DQB5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | March 1, 2003 |
Last sequence update: | March 1, 2003 | |
Last modified: | February 28, 2018 | |
This is version 120 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |