parE

Functionⁱ

Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.UniRule annotation

Catalytic activityⁱ

ATP-dependent breakage, passage and rejoining of double-stranded DNA.UniRule annotationSAAS annotation

Cofactorⁱ

Mg²⁺SAAS annotation

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	11	ATPUniRule annotation	1
Binding siteⁱ	51	ATPUniRule annotation	1
Binding siteⁱ	78	ATPUniRule annotation	1
Binding siteⁱ	344	ATPUniRule annotation	1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	118 – 124	ATPUniRule annotation		7

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-UniRule
DNA binding Source: UniProtKB-UniRule
DNA topoisomerase type II (ATP-hydrolyzing) activity Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

chromosome segregation Source: GO_Central
DNA topological change Source: GO_Central

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-bindingUniRule annotation, Isomerase, TopoisomeraseUniRule annotation
Ligand	ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCycⁱ	SPNE171101:G1FZH-796-MONOMER.

BioCycⁱ

SPNE171101:G1FZH-796-MONOMER.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: DNA topoisomerase 4 subunit BUniRule annotation (EC:5.99.1.3UniRule annotation) Alternative name(s): Topoisomerase IV subunit BUniRule annotation
Gene namesⁱ	Name:parEUniRule annotationImported Ordered Locus Names:spr0756Imported
Organismⁱ	Streptococcus pneumoniae (strain ATCC BAA-255 / R6)Imported
Taxonomic identifierⁱ	171101 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Terrabacteria group › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus › Streptococcus pneumoniae
Proteomesⁱ	UP000000586 Componentⁱ: Chromosome

Subcellular locationⁱ

GO - Cellular componentⁱ

chromosome Source: InterPro
nucleoid Source: GO_Central

View the complete GO annotation on QuickGO ...

Interactionⁱ

Subunit structureⁱ

Heterotetramer composed of ParC and ParE.UniRule annotation

Sites

Feature key	Position(s)	DescriptionActions	Length
Siteⁱ	461	Interaction with DNAUniRule annotation	1
Siteⁱ	513	Interaction with DNAUniRule annotation	1
Siteⁱ	629	Interaction with DNAUniRule annotation	1

Protein-protein interaction databases

STRINGⁱ	171101.spr0756.

STRINGⁱ

171101.spr0756.

Structureⁱ

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4LP0	X-ray	1.95	A	1-226	[»]
	4LPB	X-ray	1.75	A	1-226	[»]
	4MOT	X-ray	1.75	A	1-226	[»]
	5BOC	X-ray	2.20	A	1-226	[»]
	5BOD	X-ray	2.20	A	1-226	[»]
ProteinModelPortalⁱ	Q8DQB5.
SMRⁱ	Q8DQB5.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	427 – 541	ToprimInterPro annotationAdd BLAST		115

Sequence similaritiesⁱ

Belongs to the type II topoisomerase family. ParE type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGⁱ	ENOG4105C7D. Bacteria. COG0187. LUCA.
HOGENOMⁱ	HOG000075154.
KEGG Orthology (KO) More...KOⁱ	K02622.
OMAⁱ	KIAYAWT.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00075. HATPase_c. 1 hit.
Gene3Dⁱ	3.30.230.10. 1 hit. 3.30.565.10. 1 hit. 3.40.50.670. 1 hit.
HAMAPⁱ	MF_00939. ParE_type2. 1 hit.
InterProⁱ	View protein in InterPro IPR002288. DNA_gyrase_B_C. IPR003594. HATPase_C. IPR036890. HATPase_C_sf. IPR005740. ParE_type2. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. IPR001241. Topo_IIA. IPR013760. Topo_IIA-like_dom_sf. IPR013759. Topo_IIA_B_C. IPR013506. Topo_IIA_bsu_dom2. IPR018522. TopoIIA_CS. IPR006171. TOPRIM_domain.
PANTHERⁱ	PTHR10169. PTHR10169. 1 hit. PTHR10169:SF44. PTHR10169:SF44. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00204. DNA_gyraseB. 1 hit. PF00986. DNA_gyraseB_C. 1 hit. PF02518. HATPase_c. 1 hit. PF01751. Toprim. 1 hit.
SMARTⁱ	View protein in SMART SM00387. HATPase_c. 1 hit. SM00433. TOP2c. 1 hit.
SUPFAMⁱ	SSF54211. SSF54211. 1 hit. SSF55874. SSF55874. 1 hit. SSF56719. SSF56719. 1 hit.
TIGRFAMsⁱ	TIGR01058. parE_Gpos. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00177. TOPOISOMERASE_II. 1 hit. PS50880. TOPRIM. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q8DQB5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSKKEININN YNDDAIQVLE GLDAVRKRPG MYIGSTDGAG LHHLVWEIVD 
        60         70         80         90        100
NAVDEALSGF GDRIDVTINK DGSLTVQDHG RGMPTGMHAM GIPTVEVIFT 
       110        120        130        140        150
ILHAGGKFGQ GGYKTSGGLH GVGSSVVNAL SSWLEVEITR DGAVYKQRFE 
       160        170        180        190        200
NGGKPVTTLK KIGTALKSKT GTKVTFMPDA TIFSTTDFKY NTISERLNES 
       210        220        230        240        250
AFLLKNVTLS LTDKRTDEAI EFHYENGVQD FVSYLNEDKE ILTPVLYFEG 
       260        270        280        290        300
EDNGFQVEVA LQYNDGFSDN ILSFVNNVRT KDGGTHETGL KSAITKVMND 
       310        320        330        340        350
YARKTGLLKE KDKNLEGSDY REGLAAVLSI LVPEEHLQFE GQTKDKLGSP 
       360        370        380        390        400
LARPVVDGIV ADKLTFFLME NGELASNLIR KAIKARDARE AARKARDESR 
       410        420        430        440        450
NGKKNKKDKG LLSGKLTPAQ SKNPAKNELY LVEGDSAGGS AKQGRDRKFQ 
       460        470        480        490        500
AILPLRGKVI NTAKAKMADI LKNEEINTMI YTIGAGVGAD FSIEDANYDK 
       510        520        530        540        550
IIIMTDADTD GAHIQTLLLT FFYRYMRPLV EAGHVYIALP PLYKMSKGKG 
       560        570        580        590        600
KKEEVAYAWT DGELEELRKQ FGKGATLQRY KGLGEMNADQ LWETTMNPET 
       610        620        630        640 
RTLIRVTIED LARAERRVNV LMGDKVEPRR KWIEDNVKFT LEEATVF

Length:647

Mass (Da):71,665

Last modified:March 1, 2003 - v1

Checksum:ⁱ0AF7382C72772713

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AE007317 Genomic DNA. Translation: AAK99560.1.
PIRⁱ	D97966.
NCBI Reference Sequences More...RefSeqⁱ	NP_358350.1. NC_003098.1. WP_000037270.1. NC_003098.1.

Genome annotation databases

EnsemblBacteriaⁱ	AAK99560; AAK99560; spr0756.
GeneIDⁱ	934298.
KEGGⁱ	spr:spr0756.
PATRICⁱ	fig\|171101.6.peg.836.

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q8DQB5	A0A0H2ZNP3	Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466)	647	UniRef100_A0A0H2ZNP3	Cluster: DNA topoisomerase 4 subunit B	2

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q8DQB5	Q59961 Q3HZ66 UPI00038E921A A0A0E4CSF9 K8N1I3 K0ZGZ2 K0Z227 W1XXR7 A0A2I1YJ69 A0A2I1U312 +693	Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) Streptococcus pneumoniae Streptococcus varani Streptococcus sp. F0442 Streptococcus sp. GMD4S Streptococcus sp. GMD6S human gut metagenome Streptococcus macedonicus Streptococcus anginosus Streptococcus sp. HMSC034F03 And more	647	UniRef90_Q59961	Cluster: DNA topoisomerase 4 subunit B	704

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q8DQB5	Q59961 Q3HZ66 UPI00038E921A A0A0E4CSF9 K8N1I3 K0ZGZ2 K0Z227 W1XXR7 UPI00066C45EC J3JPI5 +1017	Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) Streptococcus pneumoniae Streptococcus varani Streptococcus sp. F0442 Streptococcus sp. GMD4S Streptococcus sp. GMD6S human gut metagenome Streptococcus pseudopneumoniae Streptococcus ratti FA-1 = DSM 20564 Streptococcus orisratti And more	647	UniRef50_Q59961	Cluster: DNA topoisomerase 4 subunit B	1,028

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AE007317 Genomic DNA. Translation: AAK99560.1.
PIRⁱ	D97966.
NCBI Reference Sequences More...RefSeqⁱ	NP_358350.1. NC_003098.1. WP_000037270.1. NC_003098.1.

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4LP0	X-ray	1.95	A	1-226	[»]
	4LPB	X-ray	1.75	A	1-226	[»]
	4MOT	X-ray	1.75	A	1-226	[»]
	5BOC	X-ray	2.20	A	1-226	[»]
	5BOD	X-ray	2.20	A	1-226	[»]
ProteinModelPortalⁱ	Q8DQB5.
SMRⁱ	Q8DQB5.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	171101.spr0756.

STRINGⁱ

171101.spr0756.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AAK99560; AAK99560; spr0756.
GeneIDⁱ	934298.
KEGGⁱ	spr:spr0756.
PATRICⁱ	fig\|171101.6.peg.836.

Phylogenomic databases

eggNOGⁱ	ENOG4105C7D. Bacteria. COG0187. LUCA.
HOGENOMⁱ	HOG000075154.
KEGG Orthology (KO) More...KOⁱ	K02622.
OMAⁱ	KIAYAWT.

Enzyme and pathway databases

BioCycⁱ	SPNE171101:G1FZH-796-MONOMER.

BioCycⁱ

SPNE171101:G1FZH-796-MONOMER.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00075. HATPase_c. 1 hit.
Gene3Dⁱ	3.30.230.10. 1 hit. 3.30.565.10. 1 hit. 3.40.50.670. 1 hit.
HAMAPⁱ	MF_00939. ParE_type2. 1 hit.
InterProⁱ	View protein in InterPro IPR002288. DNA_gyrase_B_C. IPR003594. HATPase_C. IPR036890. HATPase_C_sf. IPR005740. ParE_type2. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. IPR001241. Topo_IIA. IPR013760. Topo_IIA-like_dom_sf. IPR013759. Topo_IIA_B_C. IPR013506. Topo_IIA_bsu_dom2. IPR018522. TopoIIA_CS. IPR006171. TOPRIM_domain.
PANTHERⁱ	PTHR10169. PTHR10169. 1 hit. PTHR10169:SF44. PTHR10169:SF44. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00204. DNA_gyraseB. 1 hit. PF00986. DNA_gyraseB_C. 1 hit. PF02518. HATPase_c. 1 hit. PF01751. Toprim. 1 hit.
SMARTⁱ	View protein in SMART SM00387. HATPase_c. 1 hit. SM00433. TOP2c. 1 hit.
SUPFAMⁱ	SSF54211. SSF54211. 1 hit. SSF55874. SSF55874. 1 hit. SSF56719. SSF56719. 1 hit.
TIGRFAMsⁱ	TIGR01058. parE_Gpos. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00177. TOPOISOMERASE_II. 1 hit. PS50880. TOPRIM. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q8DQB5_STRR6
Accessionⁱ	Q8DQB5Primary (citable) accession number: Q8DQB5
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	March 1, 2003
	Last sequence update:	March 1, 2003
	Last modified:	February 28, 2018
	This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structureCombined sources, Complete proteome, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8DQB5 (Q8DQB5_STRR6)

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DNA topoisomerase 4 subunit B

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Sites

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ