Teichoic acid phosphorylcholine esterase/choline binding protein E (CbpE) - Streptococcus pneumoniae (strain ATCC BAA-255 / R6)

Preferred order of sections

Names and origin

Protein names

Submitted name:
Teichoic acid phosphorylcholine esterase/choline binding protein E (CbpE) EMBL AAK99635.1

Gene names

Name:	lytD EMBL AAK99635.1
Ordered Locus Names:	spr0831

Organism

Streptococcus pneumoniae (strain ATCC BAA-255 / R6)

Taxonomic identifier

171101 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	627 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Ligand	Calcium PDB 1WRA PDB 2BIB Metal-binding PDB 1WRA PDB 2BIB Zinc PDB 2BIB
Technical term	3D-structure PDB 1WRA PDB 2BIB Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	hydrolase activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Sites

Metal binding

61

1

Calcium 1 PDB 1WRA PDB 2BIB

Metal binding

62

1

Calcium 1 PDB 1WRA PDB 2BIB

Metal binding

62

1

Calcium 2 PDB 1WRA PDB 2BIB

Metal binding

64

1

Calcium 1; via carbonyl oxygen PDB 1WRA PDB 2BIB

Metal binding

110

1

Zinc 1; via tele nitrogen PDB 2BIB

Metal binding

112

1

Zinc 1; via pros nitrogen PDB 2BIB

Metal binding

114

1

Zinc 2 PDB 2BIB

Metal binding

115

1

Zinc 2; via tele nitrogen PDB 2BIB

Metal binding

117

1

Calcium 2; via carbonyl oxygen PDB 1WRA PDB 2BIB

Metal binding

120

1

Calcium 2 PDB 1WRA PDB 2BIB

Metal binding

121

1

Calcium 2 PDB 1WRA PDB 2BIB

Metal binding

208

1

Zinc 1 PDB 2BIB

Metal binding

228

1

Zinc 1 PDB 2BIB

Metal binding

228

1

Zinc 2 PDB 2BIB

Metal binding

254

1

Zinc 2; via tele nitrogen PDB 2BIB

Sequences

Sequence

Length

Mass (Da)

Tools

Q8DQ62 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 6B309D30177369F5
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FASTA

627

72,118

        10         20         30         40         50         60 
MKKKLTSLAL VGAFLGLSWY GNVQAQESSG NKIHFINVQE GGSDAIILES NGHFAMVDTG 

        70         80         90        100        110        120 
EDYDFPDGSD SRYPWREGIE TSYKHVLTDR VFRRLKELSV QKLDFILVTH THSDHIGNVD 

       130        140        150        160        170        180 
ELLSTYPVDR VYLKKYSDSR ITNSERLWDN LYGYDKVLQT ATETGVSVIQ NITQGDAHFQ 

       190        200        210        220        230        240 
FGDMDIQLYN YENETDSSGE LKKIWDDNSN SLISVVKVNG KKIYLGGDLD NVHGAEDKYG 

       250        260        270        280        290        300 
PLIGKVDLMK FNHHHDTNKS NTKDFIKNLS PSLIVQTSDS LPWKNGVDSE YVNWLKERGI 

       310        320        330        340        350        360 
ERINAASKDY DATVFDIRKD GFVNISTSYK PIPSFQAGWH KSAYGNWWYQ APDSTGEYAV 

       370        380        390        400        410        420 
GWNEIEGEWY YFNQTGILLQ NQWKKWNNHW FYLTDSGASA KNWKKIDGIW YYFNKENQME 

       430        440        450        460        470        480 
IGWVQDKEQW YYLDVDGSMK TGWLQYMGQW YYFAPSGEMK MGWVKDKETW YYMDSTGVMK 

       490        500        510        520        530        540 
TGEIEVAGQH YYLEDSGAMK QGWHKKANDW YFYKTDGSRA VGWIKDKDKW YFLKENGQLL 

       550        560        570        580        590        600 
VNGKTPEGYT VDSSGAWLVD VSIEKSATIK TTSHSEIKES KEVVKKDLEN KETSQHESVT 

       610        620 
NFSTSQDLTS STSQSSETSV NKSESEQ

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome of the bacterium Streptococcus pneumoniae strain R6." Hoskins J., Alborn W.E. Jr., Arnold J., Blaszczak L.C., Burgett S., DeHoff B.S., Estrem S.T., Fritz L., Fu D.-J., Fuller W., Geringer C., Gilmour R., Glass J.S., Khoja H., Kraft A.R., Lagace R.E., LeBlanc D.J., Lee L.N. Glass J.I. J. Bacteriol. 183:5709-5717(2001) [PubMed: 11544234] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-255 / R6.
[2]	"Crystal structure of phosphorylcholine esterase domain of the virulence factor choline-binding protein e from streptococcus pneumoniae: new structural features among the metallo-beta-lactamase superfamily." Garau G., Lemaire D., Vernet T., Dideberg O., Di Guilmi A.M. J. Biol. Chem. 280:28591-28600(2005) [PubMed: 15908436] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 27-334 IN COMPLEX WITH CALCIUM.
[3]	"Insights into pneumococcal pathogenesis from the crystal structure of the modular teichoic acid phosphorylcholine esterase Pce." Hermoso J.A., Lagartera L., Gonzalez A., Stelter M., Garcia P., Martinez-Ripoll M., Garcia J.L., Menendez M. Nat. Struct. Mol. Biol. 12:533-538(2005) [PubMed: 15895092] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.92 ANGSTROMS) OF 26-572 IN COMPLEX WITH CALCIUM AND ZINC.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE007317 Genomic DNA. Translation: AAK99635.1.

PIR

G97975.

RefSeq

NP_358425.1. NC_003098.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1WRA	X-ray	2.00	A/B	27-334	[»]
2BIB	X-ray	1.92	A	26-572	[»]

ProteinModelPortal

Q8DQ62.

SMR

Q8DQ62. Positions 26-565.

ModBase

Search...

Protein-protein interaction databases

STRING

Q8DQ62.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

EBSTRT00000015272; EBSTRP00000014668; EBSTRG00000015272.

GeneID

934372.

GenomeReviews

Gene locus spr0831 in contig AE007317_GR.

KEGG

spr:spr0831.

PATRIC

19701602. VBIStrPne107296_0920.

Phylogenomic databases

eggNOG

COG5263.

GeneTree

EBGT00050000026602.

HOGENOM

HBG702245.

OMA

HYYLEES.

ProtClustDB

CLSK559958.

Enzyme and pathway databases

BioCyc

SPNE171101:SPR0831-MONOMER.

Family and domain databases

InterPro

IPR001279. Beta-lactamas-like.
IPR018337. Cell_wall/Cho-bd_repeat.
[Graphical view]

Pfam

PF01473. CW_binding_1. 7 hits.
PF00753. Lactamase_B. 1 hit.
[Graphical view]

SMART

SM00849. Lactamase_B. 1 hit.
[Graphical view]

PROSITE

PS51170. CW. 10 hits.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

Q8DQ62_STRR6

Accession

Primary (citable) accession number: Q8DQ62

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2003
Last sequence update:	March 1, 2003
Last modified:	December 14, 2011
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)