Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Teichoic acid phosphorylcholine esterase/choline binding protein E (CbpE)

Gene

lytD

Organism
Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi61 – 611Calcium 1Combined sources
Metal bindingi62 – 621Calcium 1Combined sources
Metal bindingi62 – 621Calcium 2Combined sources
Metal bindingi64 – 641Calcium 1; via carbonyl oxygenCombined sources
Metal bindingi110 – 1101Iron 1; via tele nitrogenCombined sources
Metal bindingi110 – 1101Zinc 1; via tele nitrogenCombined sources
Metal bindingi112 – 1121Iron 1; via pros nitrogenCombined sources
Metal bindingi112 – 1121Zinc 1; via pros nitrogenCombined sources
Metal bindingi114 – 1141Iron 2Combined sources
Metal bindingi114 – 1141Zinc 2Combined sources
Metal bindingi115 – 1151Iron 2; via tele nitrogenCombined sources
Metal bindingi115 – 1151Zinc 2; via tele nitrogenCombined sources
Metal bindingi117 – 1171Calcium 2; via carbonyl oxygenCombined sources
Metal bindingi120 – 1201Calcium 2Combined sources
Metal bindingi121 – 1211Calcium 2Combined sources
Metal bindingi208 – 2081Iron 1Combined sources
Metal bindingi208 – 2081Zinc 1Combined sources
Metal bindingi228 – 2281Iron 1Combined sources
Metal bindingi228 – 2281Iron 2Combined sources
Metal bindingi228 – 2281Zinc 1Combined sources
Metal bindingi228 – 2281Zinc 2Combined sources
Metal bindingi254 – 2541Iron 2; via tele nitrogenCombined sources
Metal bindingi254 – 2541Zinc 2; via tele nitrogenCombined sources

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

CalciumCombined sources, IronCombined sources, Metal-bindingCombined sources, ZincCombined sources

Enzyme and pathway databases

BioCyciSPNE171101:GJC8-842-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Teichoic acid phosphorylcholine esterase/choline binding protein E (CbpE)Imported
Gene namesi
Name:lytDImported
Ordered Locus Names:spr0831Imported
OrganismiStreptococcus pneumoniae (strain ATCC BAA-255 / R6)Imported
Taxonomic identifieri171101 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000000586 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Chaini26 – 627602Sequence analysisPRO_5004304449Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi171101.spr0831.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WRAX-ray2.00A/B27-334[»]
2BIBX-ray1.92A26-572[»]
ProteinModelPortaliQ8DQ62.
SMRiQ8DQ62. Positions 26-565.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8DQ62.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini42 – 278237Lactamase_BInterPro annotationAdd
BLAST

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG4108AUE. Bacteria.
COG2333. LUCA.
HOGENOMiHOG000285074.
OMAiWYFYKTG.
OrthoDBiEOG644ZNS.

Family and domain databases

Gene3Di3.60.15.10. 1 hit.
InterProiIPR018337. Cell_wall/Cho-bd_repeat.
IPR001279. Metallo-B-lactamas.
[Graphical view]
PfamiPF01473. CW_binding_1. 7 hits.
PF00753. Lactamase_B. 1 hit.
[Graphical view]
SMARTiSM00849. Lactamase_B. 1 hit.
[Graphical view]
SUPFAMiSSF56281. SSF56281. 1 hit.
PROSITEiPS51170. CW. 10 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8DQ62-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKKLTSLAL VGAFLGLSWY GNVQAQESSG NKIHFINVQE GGSDAIILES
60 70 80 90 100
NGHFAMVDTG EDYDFPDGSD SRYPWREGIE TSYKHVLTDR VFRRLKELSV
110 120 130 140 150
QKLDFILVTH THSDHIGNVD ELLSTYPVDR VYLKKYSDSR ITNSERLWDN
160 170 180 190 200
LYGYDKVLQT ATETGVSVIQ NITQGDAHFQ FGDMDIQLYN YENETDSSGE
210 220 230 240 250
LKKIWDDNSN SLISVVKVNG KKIYLGGDLD NVHGAEDKYG PLIGKVDLMK
260 270 280 290 300
FNHHHDTNKS NTKDFIKNLS PSLIVQTSDS LPWKNGVDSE YVNWLKERGI
310 320 330 340 350
ERINAASKDY DATVFDIRKD GFVNISTSYK PIPSFQAGWH KSAYGNWWYQ
360 370 380 390 400
APDSTGEYAV GWNEIEGEWY YFNQTGILLQ NQWKKWNNHW FYLTDSGASA
410 420 430 440 450
KNWKKIDGIW YYFNKENQME IGWVQDKEQW YYLDVDGSMK TGWLQYMGQW
460 470 480 490 500
YYFAPSGEMK MGWVKDKETW YYMDSTGVMK TGEIEVAGQH YYLEDSGAMK
510 520 530 540 550
QGWHKKANDW YFYKTDGSRA VGWIKDKDKW YFLKENGQLL VNGKTPEGYT
560 570 580 590 600
VDSSGAWLVD VSIEKSATIK TTSHSEIKES KEVVKKDLEN KETSQHESVT
610 620
NFSTSQDLTS STSQSSETSV NKSESEQ
Length:627
Mass (Da):72,118
Last modified:March 1, 2003 - v1
Checksum:i6B309D30177369F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE007317 Genomic DNA. Translation: AAK99635.1.
PIRiG97975.
RefSeqiNP_358425.1. NC_003098.1.
WP_000728289.1. NC_003098.1.

Genome annotation databases

EnsemblBacteriaiAAK99635; AAK99635; spr0831.
GeneIDi934372.
KEGGispr:spr0831.
PATRICi19701602. VBIStrPne107296_0920.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE007317 Genomic DNA. Translation: AAK99635.1.
PIRiG97975.
RefSeqiNP_358425.1. NC_003098.1.
WP_000728289.1. NC_003098.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WRAX-ray2.00A/B27-334[»]
2BIBX-ray1.92A26-572[»]
ProteinModelPortaliQ8DQ62.
SMRiQ8DQ62. Positions 26-565.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi171101.spr0831.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK99635; AAK99635; spr0831.
GeneIDi934372.
KEGGispr:spr0831.
PATRICi19701602. VBIStrPne107296_0920.

Phylogenomic databases

eggNOGiENOG4108AUE. Bacteria.
COG2333. LUCA.
HOGENOMiHOG000285074.
OMAiWYFYKTG.
OrthoDBiEOG644ZNS.

Enzyme and pathway databases

BioCyciSPNE171101:GJC8-842-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ8DQ62.

Family and domain databases

Gene3Di3.60.15.10. 1 hit.
InterProiIPR018337. Cell_wall/Cho-bd_repeat.
IPR001279. Metallo-B-lactamas.
[Graphical view]
PfamiPF01473. CW_binding_1. 7 hits.
PF00753. Lactamase_B. 1 hit.
[Graphical view]
SMARTiSM00849. Lactamase_B. 1 hit.
[Graphical view]
SUPFAMiSSF56281. SSF56281. 1 hit.
PROSITEiPS51170. CW. 10 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-255 / R6Imported.
  2. "Crystal structure of phosphorylcholine esterase domain of the virulence factor choline-binding protein e from streptococcus pneumoniae: new structural features among the metallo-beta-lactamase superfamily."
    Garau G., Lemaire D., Vernet T., Dideberg O., Di Guilmi A.M.
    J. Biol. Chem. 280:28591-28600(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 27-334 IN COMPLEX WITH CALCIUM AND IRON.
  3. "Insights into pneumococcal pathogenesis from the crystal structure of the modular teichoic acid phosphorylcholine esterase Pce."
    Hermoso J.A., Lagartera L., Gonzalez A., Stelter M., Garcia P., Martinez-Ripoll M., Garcia J.L., Menendez M.
    Nat. Struct. Mol. Biol. 12:533-538(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.92 ANGSTROMS) OF 26-572 IN COMPLEX WITH CALCIUM AND ZINC.

Entry informationi

Entry nameiQ8DQ62_STRR6
AccessioniPrimary (citable) accession number: Q8DQ62
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: March 16, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.