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Q8DPP6

- LACG2_STRR6

UniProt

Q8DPP6 - LACG2_STRR6

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Protein

6-phospho-beta-galactosidase 2

Gene

lacG2

Organism
Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

A 6-phospho-beta-D-galactoside + H2O = 6-phospho-D-galactose + an alcohol.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei160 – 1601Proton donorUniRule annotation
Active sitei375 – 3751NucleophileUniRule annotation

GO - Molecular functioni

  1. 6-phospho-beta-galactosidase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. lactose catabolic process via tagatose-6-phosphate Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

BioCyciSPNE171101:GJC8-1080-MONOMER.
UniPathwayiUPA00542; UER00605.

Protein family/group databases

CAZyiGH1. Glycoside Hydrolase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phospho-beta-galactosidase 2UniRule annotation (EC:3.2.1.85UniRule annotation)
Alternative name(s):
Beta-D-phosphogalactoside galactohydrolase 2UniRule annotation
Short name:
PGALase 2UniRule annotation
P-beta-Gal 2UniRule annotation
Short name:
PBG 2UniRule annotation
Gene namesi
Name:lacG2UniRule annotation
Ordered Locus Names:spr1069
OrganismiStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Taxonomic identifieri171101 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000586: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4684686-phospho-beta-galactosidase 2PRO_0000260733Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi171101.spr1069.

Structurei

3D structure databases

ProteinModelPortaliQ8DPP6.
SMRiQ8DPP6. Positions 1-468.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 1 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2723.
HOGENOMiHOG000088632.
KOiK01220.
OMAiIGRREAP.
OrthoDBiEOG60658J.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
HAMAPiMF_01574. LacG.
InterProiIPR005928. 6P-beta-galactosidase.
IPR001360. Glyco_hydro_1.
IPR018120. Glyco_hydro_1_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10353. PTHR10353. 1 hit.
PfamiPF00232. Glyco_hydro_1. 1 hit.
[Graphical view]
PRINTSiPR00131. GLHYDRLASE1.
SUPFAMiSSF51445. SSF51445. 1 hit.
TIGRFAMsiTIGR01233. lacG. 1 hit.
PROSITEiPS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8DPP6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTKTLPKDFI FGGATAAYQA EGATHTDGKG PVAWDKYLED NYWYTAEPAS
60 70 80 90 100
DFYNRYPVDL KLAEEYGVNG IRISIAWSRI FPTGYGQVNA KGVEFYHNLF
110 120 130 140 150
AECHKRHVEP FVTLHHFDTP EALHSNGDFL NRENIEHFVD YAAFCFEEFP
160 170 180 190 200
EVNYWTTFNE IGPIGDGQYL VGKFPPGIQY DLAKVFQSHH NMMVSHARAV
210 220 230 240 250
KLYKDKGYKG EIGVVHALPT KYPLDHENPA DVRAAELEDI IHNKFILDAT
260 270 280 290 300
YLGRYSAETM EGVNHILSVN GGSLDLREED FTALEAAKDL NDFLGINYYM
310 320 330 340 350
SDWMEAFDGE TEIIHNGKGK KGSSKYQIKG VGRRVAPDYV PRTDWDWIIY
360 370 380 390 400
PQGLYDQIMR VKKDYPNYKK IYITENGLGY KDEFVDNTVY DDGRIDYVKQ
410 420 430 440 450
HLEILSDAIA DGANVKGYFI WSLMDVFSWS NGYEKRYGLF YVDFETQERY
460
PKKSAHWYKK VAETQIID
Length:468
Mass (Da):53,927
Last modified:March 1, 2003 - v1
Checksum:i075F73A048259D7A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE007317 Genomic DNA. Translation: AAK99872.1.
PIRiD98005.
RefSeqiNP_358662.1. NC_003098.1.

Genome annotation databases

EnsemblBacteriaiAAK99872; AAK99872; spr1069.
GeneIDi932827.
KEGGispr:spr1069.
PATRICi19702088. VBIStrPne107296_1161.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE007317 Genomic DNA. Translation: AAK99872.1 .
PIRi D98005.
RefSeqi NP_358662.1. NC_003098.1.

3D structure databases

ProteinModelPortali Q8DPP6.
SMRi Q8DPP6. Positions 1-468.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 171101.spr1069.

Protein family/group databases

CAZyi GH1. Glycoside Hydrolase Family 1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK99872 ; AAK99872 ; spr1069 .
GeneIDi 932827.
KEGGi spr:spr1069.
PATRICi 19702088. VBIStrPne107296_1161.

Phylogenomic databases

eggNOGi COG2723.
HOGENOMi HOG000088632.
KOi K01220.
OMAi IGRREAP.
OrthoDBi EOG60658J.

Enzyme and pathway databases

UniPathwayi UPA00542 ; UER00605 .
BioCyci SPNE171101:GJC8-1080-MONOMER.

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
HAMAPi MF_01574. LacG.
InterProi IPR005928. 6P-beta-galactosidase.
IPR001360. Glyco_hydro_1.
IPR018120. Glyco_hydro_1_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR10353. PTHR10353. 1 hit.
Pfami PF00232. Glyco_hydro_1. 1 hit.
[Graphical view ]
PRINTSi PR00131. GLHYDRLASE1.
SUPFAMi SSF51445. SSF51445. 1 hit.
TIGRFAMsi TIGR01233. lacG. 1 hit.
PROSITEi PS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-255 / R6.

Entry informationi

Entry nameiLACG2_STRR6
AccessioniPrimary (citable) accession number: Q8DPP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: March 1, 2003
Last modified: October 1, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3