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Q8DPP6

- LACG2_STRR6

UniProt

Q8DPP6 - LACG2_STRR6

Protein

6-phospho-beta-galactosidase 2

Gene

lacG2

Organism
Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    A 6-phospho-beta-D-galactoside + H2O = 6-phospho-D-galactose + an alcohol.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei160 – 1601Proton donorUniRule annotation
    Active sitei375 – 3751NucleophileUniRule annotation

    GO - Molecular functioni

    1. 6-phospho-beta-galactosidase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. lactose catabolic process via tagatose-6-phosphate Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Enzyme and pathway databases

    BioCyciSPNE171101:GJC8-1080-MONOMER.
    UniPathwayiUPA00542; UER00605.

    Protein family/group databases

    CAZyiGH1. Glycoside Hydrolase Family 1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    6-phospho-beta-galactosidase 2UniRule annotation (EC:3.2.1.85UniRule annotation)
    Alternative name(s):
    Beta-D-phosphogalactoside galactohydrolase 2UniRule annotation
    Short name:
    PGALase 2UniRule annotation
    P-beta-Gal 2UniRule annotation
    Short name:
    PBG 2UniRule annotation
    Gene namesi
    Name:lacG2UniRule annotation
    Ordered Locus Names:spr1069
    OrganismiStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
    Taxonomic identifieri171101 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000000586: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 4684686-phospho-beta-galactosidase 2PRO_0000260733Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi171101.spr1069.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8DPP6.
    SMRiQ8DPP6. Positions 1-468.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 1 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2723.
    HOGENOMiHOG000088632.
    KOiK01220.
    OMAiIGRREAP.
    OrthoDBiEOG60658J.

    Family and domain databases

    Gene3Di3.20.20.80. 1 hit.
    HAMAPiMF_01574. LacG.
    InterProiIPR005928. 6P-beta-galactosidase.
    IPR001360. Glyco_hydro_1.
    IPR018120. Glyco_hydro_1_AS.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PANTHERiPTHR10353. PTHR10353. 1 hit.
    PfamiPF00232. Glyco_hydro_1. 1 hit.
    [Graphical view]
    PRINTSiPR00131. GLHYDRLASE1.
    SUPFAMiSSF51445. SSF51445. 1 hit.
    TIGRFAMsiTIGR01233. lacG. 1 hit.
    PROSITEiPS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
    PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8DPP6-1 [UniParc]FASTAAdd to Basket

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    MTKTLPKDFI FGGATAAYQA EGATHTDGKG PVAWDKYLED NYWYTAEPAS    50
    DFYNRYPVDL KLAEEYGVNG IRISIAWSRI FPTGYGQVNA KGVEFYHNLF 100
    AECHKRHVEP FVTLHHFDTP EALHSNGDFL NRENIEHFVD YAAFCFEEFP 150
    EVNYWTTFNE IGPIGDGQYL VGKFPPGIQY DLAKVFQSHH NMMVSHARAV 200
    KLYKDKGYKG EIGVVHALPT KYPLDHENPA DVRAAELEDI IHNKFILDAT 250
    YLGRYSAETM EGVNHILSVN GGSLDLREED FTALEAAKDL NDFLGINYYM 300
    SDWMEAFDGE TEIIHNGKGK KGSSKYQIKG VGRRVAPDYV PRTDWDWIIY 350
    PQGLYDQIMR VKKDYPNYKK IYITENGLGY KDEFVDNTVY DDGRIDYVKQ 400
    HLEILSDAIA DGANVKGYFI WSLMDVFSWS NGYEKRYGLF YVDFETQERY 450
    PKKSAHWYKK VAETQIID 468
    Length:468
    Mass (Da):53,927
    Last modified:March 1, 2003 - v1
    Checksum:i075F73A048259D7A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE007317 Genomic DNA. Translation: AAK99872.1.
    PIRiD98005.
    RefSeqiNP_358662.1. NC_003098.1.

    Genome annotation databases

    EnsemblBacteriaiAAK99872; AAK99872; spr1069.
    GeneIDi932827.
    KEGGispr:spr1069.
    PATRICi19702088. VBIStrPne107296_1161.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE007317 Genomic DNA. Translation: AAK99872.1 .
    PIRi D98005.
    RefSeqi NP_358662.1. NC_003098.1.

    3D structure databases

    ProteinModelPortali Q8DPP6.
    SMRi Q8DPP6. Positions 1-468.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 171101.spr1069.

    Protein family/group databases

    CAZyi GH1. Glycoside Hydrolase Family 1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK99872 ; AAK99872 ; spr1069 .
    GeneIDi 932827.
    KEGGi spr:spr1069.
    PATRICi 19702088. VBIStrPne107296_1161.

    Phylogenomic databases

    eggNOGi COG2723.
    HOGENOMi HOG000088632.
    KOi K01220.
    OMAi IGRREAP.
    OrthoDBi EOG60658J.

    Enzyme and pathway databases

    UniPathwayi UPA00542 ; UER00605 .
    BioCyci SPNE171101:GJC8-1080-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.80. 1 hit.
    HAMAPi MF_01574. LacG.
    InterProi IPR005928. 6P-beta-galactosidase.
    IPR001360. Glyco_hydro_1.
    IPR018120. Glyco_hydro_1_AS.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    PANTHERi PTHR10353. PTHR10353. 1 hit.
    Pfami PF00232. Glyco_hydro_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00131. GLHYDRLASE1.
    SUPFAMi SSF51445. SSF51445. 1 hit.
    TIGRFAMsi TIGR01233. lacG. 1 hit.
    PROSITEi PS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
    PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-255 / R6.

    Entry informationi

    Entry nameiLACG2_STRR6
    AccessioniPrimary (citable) accession number: Q8DPP6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2006
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3