ID   Q8DPM0_STRR6            Unreviewed;       625 AA.
AC   Q8DPM0;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   27-MAR-2024, entry version 112.
DE   RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE            EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN   OrderedLocusNames=spr1102 {ECO:0000313|EMBL:AAK99905.1};
OS   Streptococcus pneumoniae (strain ATCC BAA-255 / R6).
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=171101 {ECO:0000313|EMBL:AAK99905.1, ECO:0000313|Proteomes:UP000000586};
RN   [1] {ECO:0000313|EMBL:AAK99905.1, ECO:0000313|Proteomes:UP000000586}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-255 / R6 {ECO:0000313|Proteomes:UP000000586};
RX   PubMed=11544234; DOI=10.1128/JB.183.19.5709-5717.2001;
RA   Hoskins J.A., Alborn W.Jr., Arnold J., Blaszczak L., Burgett S.,
RA   DeHoff B.S., Estrem S., Fritz L., Fu D.-J., Fuller W., Geringer C.,
RA   Gilmour R., Glass J.S., Khoja H., Kraft A., LaGace R., LeBlanc D.J.,
RA   Lee L.N., Lefkowitz E.J., Lu J., Matsushima P., McAhren S., McHenney M.,
RA   McLeaster K., Mundy C., Nicas T.I., Norris F.H., O'Gara M., Peery R.,
RA   Robertson G.T., Rockey P., Sun P.-M., Winkler M.E., Yang Y.,
RA   Young-Bellido M., Zhao G., Zook C., Baltz R.H., Jaskunas S.Richard.,
RA   Rosteck P.R.Jr., Skatrud P.L., Glass J.I.;
RT   "Genome of the bacterium Streptococcus pneumoniae strain R6.";
RL   J. Bacteriol. 183:5709-5717(2001).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC         N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC         homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC         COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC         Evidence={ECO:0000256|ARBA:ARBA00001279};
CC   -!- SIMILARITY: Belongs to the N(4)/N(6)-methyltransferase family.
CC       {ECO:0000256|ARBA:ARBA00006594}.
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DR   EMBL; AE007317; AAK99905.1; -; Genomic_DNA.
DR   PIR; E98009; E98009.
DR   PIR; G95141; G95141.
DR   RefSeq; NP_358695.1; NC_003098.1.
DR   AlphaFoldDB; Q8DPM0; -.
DR   STRING; 171101.spr1102; -.
DR   REBASE; 5624; SpnRII.
DR   KEGG; spr:spr1102; -.
DR   PATRIC; fig|171101.6.peg.1197; -.
DR   eggNOG; COG0286; Bacteria.
DR   eggNOG; COG1002; Bacteria.
DR   HOGENOM; CLU_456257_0_0_9; -.
DR   Proteomes; UP000000586; Chromosome.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR   InterPro; IPR011639; MethylTrfase_TaqI-like_dom.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   Pfam; PF07669; Eco57I; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   PROSITE; PS00092; N6_MTASE; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000313|EMBL:AAK99905.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000586}.
FT   DOMAIN          289..385
FT                   /note="Type II methyltransferase M.TaqI-like"
FT                   /evidence="ECO:0000259|Pfam:PF07669"
SQ   SEQUENCE   625 AA;  71869 MW;  3A36917CFA15A218 CRC64;
     MLMTIDISEE SLAKESADLL KILLKDRTTK KSIVWATHSY ELLGKGFAPS DRINPSKVTG
     NFANLIQPRS EKSKYEQKDR TKIRAEVFTP TWLVAKQNGY VESKLGSLSL EEYVDLRWLE
     VTCGEAPYMV TRYDTVTGEE IPLSERVGFV DRKLQRISRE VSDEVTFYKL VKDAYHASYG
     YEYQGDSLLL ARENLLATFE DYYLAKTGNQ PTLEQKKEIA TIISYNVFQM DGLKKSSPYS
     AKQKQSQQLS LFADELEVQE VEESKTHIKD WKKNRMIGFE RLSSEESEMK FDVVIGNPPY
     QETGEARDEP IYHYFIDEAY KIADKSILIT PARFLFKAGQ TPKNWMEKML EDKHLKVQFY
     ELKSGKVFTG TDIKGGVAIT YRDVDKDLGP IGVFTIFETL NGIVKKIEKH PEFETFSDLV
     YPQGIYRFSN KLFSDYPNAE KLQGKGTKNK IVSKSLTQLD FVFKNNEEKD HVALLGRIGS
     ERVYRYINKK YLDLPETFEN YNVFVPEANG SGALGEVLST PLIGEPLIGH TDTFLSIGNF
     KTKFEADACI KFIKTKFARV LLGVLKVTQH NSRKTWYYVP LQDFTVNSDI DWTQSVTDID
     RQLDQKYDLS PEEIAFIENH VREMD
//