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Q8DPI2 (ISPD_STRR6) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
EC=2.7.7.60
Alternative name(s):
4-diphosphocytidyl-2C-methyl-D-erythritol synthase
MEP cytidylyltransferase
Short name=MCT
Gene names
Name:ispD
Ordered Locus Names:spr1149
OrganismStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Taxonomic identifier171101 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length235 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) By similarity. HAMAP MF_00108

Catalytic activity

CTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol. HAMAP MF_00108

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6. HAMAP MF_00108

Sequence similarities

Belongs to the IspD family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2352352-C-methyl-D-erythritol 4-phosphate cytidylyltransferase HAMAP MF_00108
PRO_0000075632

Sites

Site141Transition state stabilizer By similarity
Site221Transition state stabilizer By similarity
Site1611Positions MEP for the nucleophilic attack By similarity
Site2181Positions MEP for the nucleophilic attack By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8DPI2 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 0CD17F5952786D97

FASTA23526,242
        10         20         30         40         50         60 
MIYAGILAGG TGTRMGISNL PKQFLELGDR PILIHTIEKF VLEPSIEKIV VGVHGDWVSH 

        70         80         90        100        110        120 
AEDLVDKYLP LYKERIIITK GGADRNTSIK NIIEAIDAYR PLTPEDIVVT HDSVRPFITL 

       130        140        150        160        170        180 
RMIQDNIQLA QNHDAVDTVV EAVDTIVEST NGQFITDIPN RAHLYQGQTP QTFRCKDFMD 

       190        200        210        220        230 
LYGSLSDEEK EILTDACKIF VIKGKDVALA KGEYSNLKIT TVTDLKIAKS MIEKD

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE007317 Genomic DNA. Translation: AAK99952.1.
PIRD98015.
RefSeqNP_358742.1. NC_003098.1.

3D structure databases

ProteinModelPortalQ8DPI2.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ8DPI2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBSTRT00000015908; EBSTRP00000015304; EBSTRG00000015908.
GeneID933316.
GenomeReviewsGene locus spr1149 in contig AE007317_GR.
KEGGspr:spr1149.
PATRIC19702262. VBIStrPne107296_1247.

Phylogenomic databases

eggNOGCOG1211.
GeneTreeEBGT00050000027822.
HOGENOMHBG672839.
OMAGELFNIK.
PhylomeDBQ8DPI2.
ProtClustDBPRK00155.

Enzyme and pathway databases

BioCycSPNE171101:SPR1149-MONOMER.

Family and domain databases

HAMAPMF_00108. IspD.
[Tree]
InterProIPR001228. ISPD_synthase.
IPR018294. ISPD_synthase_CS.
[Graphical view]
KOK00991.
PfamPF01128. IspD. 1 hit.
[Graphical view]
PROSITEPS01295. ISPD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameISPD_STRR6
AccessionPrimary (citable) accession number: Q8DPI2
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: March 1, 2003
Last modified: January 25, 2012
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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