Peptidoglycan GlcNAc deacetylase - Streptococcus pneumoniae (strain ATCC BAA-255 / R6)

Preferred order of sections

Names and origin

Protein names

Submitted name:
Peptidoglycan GlcNAc deacetylase EMBL AAL00137.1
EC=3.5.1.- EMBL AAL00137.1

Gene names

Name:	pgdA EMBL AAL00137.1
Ordered Locus Names:	spr1333

Organism

Streptococcus pneumoniae (strain ATCC BAA-255 / R6)

Taxonomic identifier

171101 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	463 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Ligand	Metal-binding PDB 2C1G PDB 2C1I Zinc PDB 2C1G PDB 2C1I
Molecular function	Hydrolase EMBL AAL00137.1
Technical term	3D-structure PDB 2C1G PDB 2C1I Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Sites

Metal binding

144

1

Zinc 1 PDB 2C1G PDB 2C1I

Metal binding

146

1

Zinc 1 PDB 2C1G PDB 2C1I

Metal binding

276

1

Zinc 2 PDB 2C1G PDB 2C1I

Metal binding

326

1

Zinc 2; via tele nitrogen PDB 2C1G PDB 2C1I

Metal binding

330

1

Zinc 2; via tele nitrogen PDB 2C1G PDB 2C1I

Sequences

Sequence

Length

Mass (Da)

Tools

Q8DP63 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 12E1935E66521EDE
Show »

FASTA

463

52,675

        10         20         30         40         50         60 
MNKSRLGRGR HGKTRHVLLA LIGILAISIC LLGGFIAFKI YQQKSFEQKI ESLKKEKDDQ 

        70         80         90        100        110        120 
LSEGNQKEHF RQGQAEVIAY YPLQGEKVIS SVRELINQDV KDKLESKDNL VFYYTEQEES 

       130        140        150        160        170        180 
GLKGVVNRNV TKQIYDLVAF KIEETEKTSL GKVHLTEDGQ PFTLDQLFSD ASKAKEQLIK 

       190        200        210        220        230        240 
ELTSFIEDKK IEQDQSEQIV KNFSDQDLSA WNFDYKDSQI ILYPSPVVEN LEEIALPVSA 

       250        260        270        280        290        300 
FFDVIQSSYL LEKDAALYQS YFDKKHQKVV ALTFDDGPNP ATTPQVLETL AKYDIKATFF 

       310        320        330        340        350        360 
VLGKNVSGNE DLVKRIKSEG HVVGNHSWSH PILSQLSLDE AKKQITDTED VLTKVLGSSS 

       370        380        390        400        410        420 
KLMRPPYGAI TDDIRNSLDL SFIMWDVDSL DWKSKNEASI LTEIQHQVAN GSIVLMHDIH 

       430        440        450        460 
SPTVNALPRV IEYLKNQGYT FVTIPEMLNT RLKAHELYYS RDE

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome of the bacterium Streptococcus pneumoniae strain R6." Hoskins J., Alborn W.E. Jr., Arnold J., Blaszczak L.C., Burgett S., DeHoff B.S., Estrem S.T., Fritz L., Fu D.-J., Fuller W., Geringer C., Gilmour R., Glass J.S., Khoja H., Kraft A.R., Lagace R.E., LeBlanc D.J., Lee L.N. Glass J.I. J. Bacteriol. 183:5709-5717(2001) [PubMed: 11544234] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-255 / R6.
[2]	"Structure and metal-dependent mechanism of peptidoglycan deacetylase, a streptococcal virulence factor." Blair D.E., Schuttelkopf A.W., MacRae J.I., van Aalten D.M. Proc. Natl. Acad. Sci. U.S.A. 102:15429-15434(2005) [PubMed: 16221761] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.35 ANGSTROMS) OF 38-463 IN COMPLEX WITH ZINC.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE007317 Genomic DNA. Translation: AAL00137.1.

PIR

D98038.

RefSeq

NP_358926.1. NC_003098.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2C1G	X-ray	1.75	A	38-463	[»]
2C1I	X-ray	1.35	A	38-463	[»]

ProteinModelPortal

Q8DP63.

SMR

Q8DP63. Positions 46-463.

ModBase

Search...

Protein-protein interaction databases

STRING

Q8DP63.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

EBSTRT00000015857; EBSTRP00000015253; EBSTRG00000015857.

GeneID

934547.

GenomeReviews

Gene locus spr1333 in contig AE007317_GR.

KEGG

spr:spr1333.

PATRIC

19702660. VBIStrPne107296_1445.

Phylogenomic databases

eggNOG

COG0726.

GeneTree

EBGT00050000027091.

HOGENOM

HBG703418.

OMA

LVAFKIE.

PhylomeDB

Q8DP63.

ProtClustDB

CLSK884105.

Enzyme and pathway databases

BioCyc

SPNE171101:SPR1333-MONOMER.

Family and domain databases

InterPro

IPR011330. Glyco_hydro/deAcase_b/a-brl.
IPR017219. Peptidoglycan_deacetylase.
IPR002509. Polysac_deacetylase.
[Graphical view]

Gene3D

G3DSA:3.20.20.370. Polysac_deacetylase. 1 hit.

KO

K01463.

Pfam

PF01522. Polysacc_deac_1. 1 hit.
[Graphical view]

PIRSF

PIRSF037479. PG_GlcNAc_deacetylase. 1 hit.

SUPFAM

SSF88713. Glyco_hydro/deAcase_b/a-brl. 1 hit.

ProtoNet

Search...

Entry information

Entry name

Q8DP63_STRR6

Accession

Primary (citable) accession number: Q8DP63

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2003
Last sequence update:	March 1, 2003
Last modified:	December 14, 2011
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)