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Protein

Cell division protein FtsZ

Gene

ftsZ

Organism
Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei140GTPUniRule annotation1
Binding sitei144GTPUniRule annotation1
Binding sitei188GTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi22 – 26GTPUniRule annotation5
Nucleotide bindingi109 – 111GTPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, SeptationUniRule annotation
LigandGTP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division protein FtsZUniRule annotation
Gene namesi
Name:ftsZUniRule annotationImported
Ordered Locus Names:spr1510Imported
OrganismiStreptococcus pneumoniae (strain ATCC BAA-255 / R6)Imported
Taxonomic identifieri171101 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000000586 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation
  • Note: Assembles at midcell at the inner surface of the cytoplasmic membrane.UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Proteomic databases

PRIDEiQ8DNV9.

Interactioni

Subunit structurei

Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.UniRule annotation

Binary interactionsi

WithEntry#Exp.IntActNotes
mapZQ8DR552EBI-16131344,EBI-16131327

Protein-protein interaction databases

DIPiDIP-61346N.
IntActiQ8DNV9. 1 interactor.
STRINGi171101.spr1510.

Structurei

3D structure databases

ProteinModelPortaliQ8DNV9.
SMRiQ8DNV9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 206TubulinInterPro annotationAdd BLAST193
Domaini208 – 325Tubulin_CInterPro annotationAdd BLAST118

Sequence similaritiesi

Belongs to the FtsZ family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CDK. Bacteria.
COG0206. LUCA.
HOGENOMiHOG000049094.
KOiK03531.
OMAiMRAVKGI.

Family and domain databases

CDDicd02201. FtsZ_type1. 1 hit.
Gene3Di3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
HAMAPiMF_00909. FtsZ. 1 hit.
InterProiView protein in InterPro
IPR000158. Cell_div_FtsZ.
IPR020805. Cell_div_FtsZ_CS.
IPR024757. FtsZ_C.
IPR008280. Tub_FtsZ_C.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR037103. Tubulin/FtsZ_C_sf.
IPR036525. Tubulin/FtsZ_GTPase_sf.
IPR003008. Tubulin_FtsZ_GTPase.
PfamiView protein in Pfam
PF12327. FtsZ_C. 1 hit.
PF00091. Tubulin. 1 hit.
PRINTSiPR00423. CELLDVISFTSZ.
SMARTiView protein in SMART
SM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
TIGRFAMsiTIGR00065. ftsZ. 1 hit.
PROSITEiView protein in PROSITE
PS01134. FTSZ_1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8DNV9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTFSFDTAAA QGAVIKVIGV GGGGGNAINR MVDEGVTGVE FIAANTDVQA
60 70 80 90 100
LSSTKAETVI QLGPKLTRGL GAGGQPEVGR KAAEESEETL TEAISGADMV
110 120 130 140 150
FITAGMGGGS GTGAAPVIAR IAKDLGALTV GVVTRPFGFE GSKRGQFAVE
160 170 180 190 200
GINQLREHVD TLLIISNNNL LEIVDKKTPL LEALSEADNV LRQGVQGITD
210 220 230 240 250
LITNPGLINL DFADVKTVMA NKGNALMGIG IGSGEERVVE AARKAIYSPL
260 270 280 290 300
LETTIDGAED VIVNVTGGLD LTLIEAEEAS QIVNQAAGQG VNIWLGTSID
310 320 330 340 350
ESMRDEIRVT VVATGVRQDR VEKVVAPQAR SATNYRETVK PAHSHGFDRH
360 370 380 390 400
FDMAETVELP KQNPRRLEPT QASAFGDWDL RRESIVRTTD SVVSPVERFE
410
APISQDEDEL DTPPFFKNR
Length:419
Mass (Da):44,416
Last modified:March 1, 2003 - v1
Checksum:iEEBB217812BD2B90
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE007317 Genomic DNA. Translation: AAL00314.1.
PIRiE98060.
H95193.
RefSeqiNP_359103.1. NC_003098.1.
WP_000144280.1. NC_003098.1.

Genome annotation databases

EnsemblBacteriaiAAL00314; AAL00314; spr1510.
GeneIDi933826.
KEGGispr:spr1510.
PATRICifig|171101.6.peg.1630.

Similar proteinsi

Entry informationi

Entry nameiQ8DNV9_STRR6
AccessioniPrimary (citable) accession number: Q8DNV9
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: October 25, 2017
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported