Q8DNU0 (Q8DNU0_STRR6) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Phospho-2-dehydro-3-deoxyheptonate aldolase PIRNR PIRNR001361
EC=2.5.1.54 PIRNR PIRNR001361

Alternative name(s):
3-deoxy-D-arabino-heptulosonate 7-phosphate synthase PIRNR PIRNR001361
DAHP synthase PIRNR PIRNR001361
Phospho-2-keto-3-deoxyheptonate aldolase PIRNR PIRNR001361

Gene names

Name:	aroF EMBL AAL00346.1
Ordered Locus Names:	spr1542

Organism

Streptococcus pneumoniae (strain ATCC BAA-255 / R6)

Taxonomic identifier

171101 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	343 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) By similarity. PIRNR PIRNR001361
Catalytic activity	Phosphoenolpyruvate + D-erythrose 4-phosphate + H2O = 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate. PIRNR PIRNR001361
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7. PIRNR PIRNR001361
Sequence similarities	Belongs to the class-I DAHP synthase family. PIRNR PIRNR001361

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis PIRNR PIRNR001361
Molecular function	Transferase PIRNR PIRNR001361 EMBL AAL00346.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3-deoxy-7-phosphoheptulonate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8DNU0 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 573CC7A247AD71ED	FASTA	343	38,753
	10 20 30 40 50 60 MAFIEKGQEI DMEVIKAETQ LSAEALRLKE SRDRELADII SGEDDRILLV IGPCSSDNEE 70 80 90 100 110 120 AVLEYARRLS ALQKKVADKI FMVMRVYTAK PRTNGDGYKG LVHQPDTSKA PSLINGLQAV 130 140 150 160 170 180 RQLHYRVITE TGLTTADEML YPSNLILVDD LVSYHAVGAR SVEDQEHRFV ASGIDAPVGM 190 200 210 220 230 240 KNPTSGNLGV MFNAIYAAQN KQTFLYHGQE VETSGNPLAH VILRGAVNEY GNYMPNYYYE 250 260 270 280 290 300 NLLQAIERYE TMGLENPFIL IDTNHDNSGK QYMEQIRIVR QTLQNRDWNE KIKKTVRGFM 310 320 330 340 IESYLADGRQ NQPEIFGCSI TDPCLGWENT EALVEEIYVT LTK

References

[1]

"Genome of the bacterium Streptococcus pneumoniae strain R6." Hoskins J., Alborn W.E. Jr., Arnold J., Blaszczak L.C., Burgett S., DeHoff B.S., Estrem S.T., Fritz L., Fu D.-J., Fuller W., Geringer C., Gilmour R., Glass J.S., Khoja H., Kraft A.R., Lagace R.E., LeBlanc D.J., Lee L.N. , Lefkowitz E.J., Lu J., Matsushima P., McAhren S.M., McHenney M., McLeaster K., Mundy C.W., Nicas T.I., Norris F.H., O'Gara M., Peery R.B., Robertson G.T., Rockey P., Sun P.-M., Winkler M.E., Yang Y., Young-Bellido M., Zhao G., Zook C.A., Baltz R.H., Jaskunas S.R., Rosteck P.R. Jr., Skatrud P.L., Glass J.I. J. Bacteriol. 183:5709-5717(2001) [PubMed: 11544234] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-255 / R6.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE007317 Genomic DNA. Translation: AAL00346.1.
PIR	A95198. E98064.
RefSeq	NP_359135.1. NC_003098.1.
3D structure databases
HSSP	HSSP built from PDB template 1KFL based on UniProtKB P00886.
ProteinModelPortal	Q8DNU0.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8DNU0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTRT00000015090; EBSTRP00000014486; EBSTRG00000015090.
GeneID	932815.
GenomeReviews	Gene locus spr1542 in contig AE007317_GR.
KEGG	spr:spr1542.
PATRIC	19703101. VBIStrPne107296_1665.
Phylogenomic databases
eggNOG	COG0722.
GeneTree	EBGT00050000028141.
HOGENOM	HBG670536.
OMA	MDNSFKL.
PhylomeDB	Q8DNU0.
ProtClustDB	PRK09261.
Enzyme and pathway databases
BioCyc	SPNE171101:SPR1542-MONOMER.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR006218. DAHP1/KDSA. IPR006219. DHAP_synth_1. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01626.
PANTHER	PTHR21225. AroFGH. 1 hit.
Pfam	PF00793. DAHP_synth_1. 1 hit. [Graphical view]
PIRSF	PIRSF001361. DAHP_synthase. 1 hit.
TIGRFAMs	TIGR00034. AroFGH. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q8DNU0_STRR6

Accession

Primary (citable) accession number: Q8DNU0

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2003
Last sequence update:	March 1, 2003
Last modified:	January 25, 2012
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)