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Q8DNR9

- PHPP_STRR6

UniProt

Q8DNR9 - PHPP_STRR6

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Protein
Protein phosphatase PhpP
Gene
phpP, pppL, spr1578
Organism
Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Protein phosphatase able to dephosphorylate StkP-P and other phosphorylated protein substrates. PhpP and its cognate protein kinase StkP appear to constitute a functional signaling couple in vivo, PhpP's primary role being probably to control phosphorylation levels of StkP and of its targets. PhpP thus performs an essential control of StkP activity By similarity.

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 manganese ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi36 – 361Manganese 1 By similarity
Metal bindingi36 – 361Manganese 2 By similarity
Metal bindingi37 – 371Manganese 1; via carbonyl oxygen By similarity
Metal bindingi192 – 1921Manganese 2 By similarity
Metal bindingi231 – 2311Manganese 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciSPNE171101:GJC8-1591-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein phosphatase PhpP (EC:3.1.3.16)
    Alternative name(s):
    PP2C-type phosphatase
    Ser/Thr phosphoprotein phosphatase
    Short name:
    STPP
    Gene namesi
    Name:phpP
    Synonyms:pppL
    Ordered Locus Names:spr1578
    OrganismiStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
    Taxonomic identifieri171101 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000000586: Chromosome

    Subcellular locationi

    Cytoplasm
    Note: Mainly localizes to the midcell division sites. Delocalizes from the septum in the presence of antibiotics that target the latest stages of cell-wall biosynthesis and in cells that have stopped dividing.1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 246246Protein phosphatase PhpP
    PRO_0000418148Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi171101.spr1578.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8DNR9.
    SMRiQ8DNR9. Positions 1-238.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PP2C family.

    Phylogenomic databases

    eggNOGiCOG0631.
    HOGENOMiHOG000235782.
    KOiK01090.
    OMAiHEECQGM.
    OrthoDBiEOG65N17S.

    Family and domain databases

    Gene3Di3.60.40.10. 1 hit.
    InterProiIPR001932. PP2C-like_dom.
    IPR015655. Protein_Pase_2C.
    [Graphical view]
    PANTHERiPTHR13832. PTHR13832. 1 hit.
    SMARTiSM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view]
    SUPFAMiSSF81606. SSF81606. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8DNR9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEISLLTDVG QKRTNNQDYV NHYVNRAGRT MIILADGMGG HRAGNIASEM    50
    AVTDLGVAWV DTQIDTVNEV REWFAHYLEI ENQKIHQLGQ DEAYRGMGTT 100
    LEVLAIIDNQ AIYAHIGDSR IGLIRGEEYH QLTSDHSLVN ELLKAGQLTP 150
    EEAEAHPQKN IITQSIGQKD EIQPDFGTVI LESGDYLLLN SDGLTNMISG 200
    SEIRDIVTSD IPLADKTETL VRFANNAGGL DNITVALVSM NEEDAE 246
    Length:246
    Mass (Da):27,103
    Last modified:March 1, 2003 - v1
    Checksum:iC7D368C6ECE86E94
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE007317 Genomic DNA. Translation: AAL00381.1.
    PIRiH95201.
    H98068.
    RefSeqiNP_359170.1. NC_003098.1.

    Genome annotation databases

    EnsemblBacteriaiAAL00381; AAL00381; spr1578.
    GeneIDi933328.
    KEGGispr:spr1578.
    PATRICi19703179. VBIStrPne107296_1705.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE007317 Genomic DNA. Translation: AAL00381.1 .
    PIRi H95201.
    H98068.
    RefSeqi NP_359170.1. NC_003098.1.

    3D structure databases

    ProteinModelPortali Q8DNR9.
    SMRi Q8DNR9. Positions 1-238.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 171101.spr1578.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL00381 ; AAL00381 ; spr1578 .
    GeneIDi 933328.
    KEGGi spr:spr1578.
    PATRICi 19703179. VBIStrPne107296_1705.

    Phylogenomic databases

    eggNOGi COG0631.
    HOGENOMi HOG000235782.
    KOi K01090.
    OMAi HEECQGM.
    OrthoDBi EOG65N17S.

    Enzyme and pathway databases

    BioCyci SPNE171101:GJC8-1591-MONOMER.

    Family and domain databases

    Gene3Di 3.60.40.10. 1 hit.
    InterProi IPR001932. PP2C-like_dom.
    IPR015655. Protein_Pase_2C.
    [Graphical view ]
    PANTHERi PTHR13832. PTHR13832. 1 hit.
    SMARTi SM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81606. SSF81606. 1 hit.
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-255 / R6.
    2. "Control of cell division in Streptococcus pneumoniae by the conserved Ser/Thr protein kinase StkP."
      Beilharz K., Novakova L., Fadda D., Branny P., Massidda O., Veening J.W.
      Proc. Natl. Acad. Sci. U.S.A. 109:E905-E913(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, OVEREXPRESSION.
      Strain: ATCC BAA-255 / R6.

    Entry informationi

    Entry nameiPHPP_STRR6
    AccessioniPrimary (citable) accession number: Q8DNR9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2012
    Last sequence update: March 1, 2003
    Last modified: May 14, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Overexpression of PhpP leads to a phenotype comparable to cells lacking stkP, with an increased cell length.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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