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Protein

Protein phosphatase PhpP

Gene

phpP

Organism
Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Protein phosphatase able to dephosphorylate StkP-P and other phosphorylated protein substrates. PhpP and its cognate protein kinase StkP appear to constitute a functional signaling couple in vivo, PhpP's primary role being probably to control phosphorylation levels of StkP and of its targets. PhpP thus performs an essential control of StkP activity (By similarity).By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi36 – 361Manganese 1By similarity
Metal bindingi36 – 361Manganese 2By similarity
Metal bindingi37 – 371Manganese 1; via carbonyl oxygenBy similarity
Metal bindingi192 – 1921Manganese 2By similarity
Metal bindingi231 – 2311Manganese 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciSPNE171101:GJC8-1591-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase PhpP (EC:3.1.3.16)
Alternative name(s):
PP2C-type phosphatase
Ser/Thr phosphoprotein phosphatase
Short name:
STPP
Gene namesi
Name:phpP
Synonyms:pppL
Ordered Locus Names:spr1578
OrganismiStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Taxonomic identifieri171101 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000586: Chromosome

Subcellular locationi

Cytoplasm 1 Publication
Note: Mainly localizes to the midcell division sites. Delocalizes from the septum in the presence of antibiotics that target the latest stages of cell-wall biosynthesis and in cells that have stopped dividing.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 246246Protein phosphatase PhpPPRO_0000418148Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi171101.spr1578.

Structurei

3D structure databases

ProteinModelPortaliQ8DNR9.
SMRiQ8DNR9. Positions 1-238.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PP2C family.Curated

Phylogenomic databases

eggNOGiCOG0631.
HOGENOMiHOG000235782.
KOiK01090.
OMAiFFIVADG.
OrthoDBiEOG65N17S.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8DNR9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEISLLTDVG QKRTNNQDYV NHYVNRAGRT MIILADGMGG HRAGNIASEM
60 70 80 90 100
AVTDLGVAWV DTQIDTVNEV REWFAHYLEI ENQKIHQLGQ DEAYRGMGTT
110 120 130 140 150
LEVLAIIDNQ AIYAHIGDSR IGLIRGEEYH QLTSDHSLVN ELLKAGQLTP
160 170 180 190 200
EEAEAHPQKN IITQSIGQKD EIQPDFGTVI LESGDYLLLN SDGLTNMISG
210 220 230 240
SEIRDIVTSD IPLADKTETL VRFANNAGGL DNITVALVSM NEEDAE
Length:246
Mass (Da):27,103
Last modified:March 1, 2003 - v1
Checksum:iC7D368C6ECE86E94
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE007317 Genomic DNA. Translation: AAL00381.1.
PIRiH95201.
H98068.
RefSeqiNP_359170.1. NC_003098.1.

Genome annotation databases

EnsemblBacteriaiAAL00381; AAL00381; spr1578.
GeneIDi933328.
KEGGispr:spr1578.
PATRICi19703179. VBIStrPne107296_1705.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE007317 Genomic DNA. Translation: AAL00381.1.
PIRiH95201.
H98068.
RefSeqiNP_359170.1. NC_003098.1.

3D structure databases

ProteinModelPortaliQ8DNR9.
SMRiQ8DNR9. Positions 1-238.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi171101.spr1578.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL00381; AAL00381; spr1578.
GeneIDi933328.
KEGGispr:spr1578.
PATRICi19703179. VBIStrPne107296_1705.

Phylogenomic databases

eggNOGiCOG0631.
HOGENOMiHOG000235782.
KOiK01090.
OMAiFFIVADG.
OrthoDBiEOG65N17S.

Enzyme and pathway databases

BioCyciSPNE171101:GJC8-1591-MONOMER.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-255 / R6.
  2. "Control of cell division in Streptococcus pneumoniae by the conserved Ser/Thr protein kinase StkP."
    Beilharz K., Novakova L., Fadda D., Branny P., Massidda O., Veening J.W.
    Proc. Natl. Acad. Sci. U.S.A. 109:E905-E913(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, OVEREXPRESSION.
    Strain: ATCC BAA-255 / R6.

Entry informationi

Entry nameiPHPP_STRR6
AccessioniPrimary (citable) accession number: Q8DNR9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2012
Last sequence update: March 1, 2003
Last modified: January 7, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Overexpression of PhpP leads to a phenotype comparable to cells lacking stkP, with an increased cell length.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.