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Q8DNR9

- PHPP_STRR6

UniProt

Q8DNR9 - PHPP_STRR6

Protein

Protein phosphatase PhpP

Gene

phpP

Organism
Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Protein phosphatase able to dephosphorylate StkP-P and other phosphorylated protein substrates. PhpP and its cognate protein kinase StkP appear to constitute a functional signaling couple in vivo, PhpP's primary role being probably to control phosphorylation levels of StkP and of its targets. PhpP thus performs an essential control of StkP activity By similarity.By similarity

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi36 – 361Manganese 1By similarity
    Metal bindingi36 – 361Manganese 2By similarity
    Metal bindingi37 – 371Manganese 1; via carbonyl oxygenBy similarity
    Metal bindingi192 – 1921Manganese 2By similarity
    Metal bindingi231 – 2311Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. phosphoprotein phosphatase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciSPNE171101:GJC8-1591-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein phosphatase PhpP (EC:3.1.3.16)
    Alternative name(s):
    PP2C-type phosphatase
    Ser/Thr phosphoprotein phosphatase
    Short name:
    STPP
    Gene namesi
    Name:phpP
    Synonyms:pppL
    Ordered Locus Names:spr1578
    OrganismiStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
    Taxonomic identifieri171101 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000000586: Chromosome

    Subcellular locationi

    Cytoplasm 1 Publication
    Note: Mainly localizes to the midcell division sites. Delocalizes from the septum in the presence of antibiotics that target the latest stages of cell-wall biosynthesis and in cells that have stopped dividing.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 246246Protein phosphatase PhpPPRO_0000418148Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi171101.spr1578.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8DNR9.
    SMRiQ8DNR9. Positions 1-238.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PP2C family.Curated

    Phylogenomic databases

    eggNOGiCOG0631.
    HOGENOMiHOG000235782.
    KOiK01090.
    OMAiHEECQGM.
    OrthoDBiEOG65N17S.

    Family and domain databases

    Gene3Di3.60.40.10. 1 hit.
    InterProiIPR001932. PP2C-like_dom.
    IPR015655. Protein_Pase_2C.
    [Graphical view]
    PANTHERiPTHR13832. PTHR13832. 1 hit.
    SMARTiSM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view]
    SUPFAMiSSF81606. SSF81606. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8DNR9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEISLLTDVG QKRTNNQDYV NHYVNRAGRT MIILADGMGG HRAGNIASEM    50
    AVTDLGVAWV DTQIDTVNEV REWFAHYLEI ENQKIHQLGQ DEAYRGMGTT 100
    LEVLAIIDNQ AIYAHIGDSR IGLIRGEEYH QLTSDHSLVN ELLKAGQLTP 150
    EEAEAHPQKN IITQSIGQKD EIQPDFGTVI LESGDYLLLN SDGLTNMISG 200
    SEIRDIVTSD IPLADKTETL VRFANNAGGL DNITVALVSM NEEDAE 246
    Length:246
    Mass (Da):27,103
    Last modified:March 1, 2003 - v1
    Checksum:iC7D368C6ECE86E94
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE007317 Genomic DNA. Translation: AAL00381.1.
    PIRiH95201.
    H98068.
    RefSeqiNP_359170.1. NC_003098.1.

    Genome annotation databases

    EnsemblBacteriaiAAL00381; AAL00381; spr1578.
    GeneIDi933328.
    KEGGispr:spr1578.
    PATRICi19703179. VBIStrPne107296_1705.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE007317 Genomic DNA. Translation: AAL00381.1 .
    PIRi H95201.
    H98068.
    RefSeqi NP_359170.1. NC_003098.1.

    3D structure databases

    ProteinModelPortali Q8DNR9.
    SMRi Q8DNR9. Positions 1-238.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 171101.spr1578.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL00381 ; AAL00381 ; spr1578 .
    GeneIDi 933328.
    KEGGi spr:spr1578.
    PATRICi 19703179. VBIStrPne107296_1705.

    Phylogenomic databases

    eggNOGi COG0631.
    HOGENOMi HOG000235782.
    KOi K01090.
    OMAi HEECQGM.
    OrthoDBi EOG65N17S.

    Enzyme and pathway databases

    BioCyci SPNE171101:GJC8-1591-MONOMER.

    Family and domain databases

    Gene3Di 3.60.40.10. 1 hit.
    InterProi IPR001932. PP2C-like_dom.
    IPR015655. Protein_Pase_2C.
    [Graphical view ]
    PANTHERi PTHR13832. PTHR13832. 1 hit.
    SMARTi SM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81606. SSF81606. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-255 / R6.
    2. "Control of cell division in Streptococcus pneumoniae by the conserved Ser/Thr protein kinase StkP."
      Beilharz K., Novakova L., Fadda D., Branny P., Massidda O., Veening J.W.
      Proc. Natl. Acad. Sci. U.S.A. 109:E905-E913(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, OVEREXPRESSION.
      Strain: ATCC BAA-255 / R6.

    Entry informationi

    Entry nameiPHPP_STRR6
    AccessioniPrimary (citable) accession number: Q8DNR9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2012
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Overexpression of PhpP leads to a phenotype comparable to cells lacking stkP, with an increased cell length.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3