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Q8DNR9 (PHPP_STRR6) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein phosphatase PhpP

EC=3.1.3.16
Alternative name(s):
PP2C-type phosphatase
Ser/Thr phosphoprotein phosphatase
Short name=STPP
Gene names
Name:phpP
Synonyms:pppL
Ordered Locus Names:spr1578
OrganismStreptococcus pneumoniae (strain ATCC BAA-255 / R6) [Reference proteome] [HAMAP]
Taxonomic identifier171101 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length246 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Protein phosphatase able to dephosphorylate StkP-P and other phosphorylated protein substrates. PhpP and its cognate protein kinase StkP appear to constitute a functional signaling couple in vivo, PhpP's primary role being probably to control phosphorylation levels of StkP and of its targets. PhpP thus performs an essential control of StkP activity By similarity.

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactor

Binds 2 manganese ions per subunit By similarity.

Subcellular location

Cytoplasm. Note: Mainly localizes to the midcell division sites. Delocalizes from the septum in the presence of antibiotics that target the latest stages of cell-wall biosynthesis and in cells that have stopped dividing. Ref.2

Miscellaneous

Overexpression of PhpP leads to a phenotype comparable to cells lacking stkP, with an increased cell length.

Sequence similarities

Belongs to the PP2C family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandManganese
Metal-binding
   Molecular functionHydrolase
Protein phosphatase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoprotein phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 246246Protein phosphatase PhpP
PRO_0000418148

Sites

Metal binding361Manganese 1 By similarity
Metal binding361Manganese 2 By similarity
Metal binding371Manganese 1; via carbonyl oxygen By similarity
Metal binding1921Manganese 2 By similarity
Metal binding2311Manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8DNR9 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: C7D368C6ECE86E94

FASTA24627,103
        10         20         30         40         50         60 
MEISLLTDVG QKRTNNQDYV NHYVNRAGRT MIILADGMGG HRAGNIASEM AVTDLGVAWV 

        70         80         90        100        110        120 
DTQIDTVNEV REWFAHYLEI ENQKIHQLGQ DEAYRGMGTT LEVLAIIDNQ AIYAHIGDSR 

       130        140        150        160        170        180 
IGLIRGEEYH QLTSDHSLVN ELLKAGQLTP EEAEAHPQKN IITQSIGQKD EIQPDFGTVI 

       190        200        210        220        230        240 
LESGDYLLLN SDGLTNMISG SEIRDIVTSD IPLADKTETL VRFANNAGGL DNITVALVSM 


NEEDAE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE007317 Genomic DNA. Translation: AAL00381.1.
PIRH95201.
H98068.
RefSeqNP_359170.1. NC_003098.1.

3D structure databases

ProteinModelPortalQ8DNR9.
SMRQ8DNR9. Positions 1-238.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING171101.spr1578.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL00381; AAL00381; spr1578.
GeneID933328.
KEGGspr:spr1578.
PATRIC19703179. VBIStrPne107296_1705.

Phylogenomic databases

eggNOGCOG0631.
HOGENOMHOG000235782.
KOK01090.
OMAHEECQGM.
OrthoDBEOG65N17S.

Enzyme and pathway databases

BioCycSPNE171101:GJC8-1591-MONOMER.

Family and domain databases

Gene3D3.60.40.10. 1 hit.
InterProIPR001932. PP2C-like_dom.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERPTHR13832. PTHR13832. 1 hit.
SMARTSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMSSF81606. SSF81606. 1 hit.
ProtoNetSearch...

Entry information

Entry namePHPP_STRR6
AccessionPrimary (citable) accession number: Q8DNR9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2012
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families