Q8DNL8 (GALT1_STRR6) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Galactose-1-phosphate uridylyltransferase 1
Short name=Gal-1-P uridylyltransferase 1
EC=2.7.7.12

Alternative name(s):
UDP-glucose--hexose-1-phosphate uridylyltransferase 1

Gene names

Name:	galT1
Ordered Locus Names:	spr1648

Organism

Streptococcus pneumoniae (strain ATCC BAA-255 / R6)

Taxonomic identifier

171101 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	491 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	UDP-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-galactose. HAMAP MF_00571
Pathway	Carbohydrate metabolism; galactose metabolism. HAMAP MF_00571
Subcellular location	Cytoplasm Potential HAMAP MF_00571.
Sequence similarities	Belongs to the galactose-1-phosphate uridylyltransferase type 2 family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Galactose metabolism
Cellular component	Cytoplasm
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	galactose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	UDP-glucose:hexose-1-phosphate uridylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 491	491	Galactose-1-phosphate uridylyltransferase 1 HAMAP MF_00571		PRO_0000169916

Sequences

	Sequence		Length	Mass (Da)
	Q8DNL8 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: A67A027CDA34F56A	FASTA	491	56,448
	10 20 30 40 50 60 MKTIIDNFVD RVIEYGMYNE IDKIYVKNRV LALIGEEGTD RISDENDLKQ IKDYLVEIAL 70 80 90 100 110 120 KNGKIKDLIE EKECLGAELM NFIVPLPSRL NDIFWSSYDI SPQEAVEEFY KLSKDSDYIK 130 140 150 160 170 180 TSAIAKNIEF RASTKYGELE ITINLSKPEK DPKTIAAEKL VKATNYPKCL LCMENEGYQG 190 200 210 220 230 240 RINYPARSNH RIIRLKLGDE VWGFQYSPYL YFNEHAIFLN SQHVPMAITS KTFEQLLEIV 250 260 270 280 290 300 DILPGYFAGS NSDLPISGGS ILSHNHYQGG KHIFPMEKAK FESEFRFKDF EDVNAGIVKW 310 320 330 340 350 360 PMSVIRLQSE NKNRLLDLAT KILNKWREYS DLEVDIIAMT EDVPHHTVTP IARKVDGRYE 370 380 390 400 410 420 LDIVLRDNHT TEQYPDGVFH PHQDVQHIKK ENIGLIEVMG LAILPPRLKP ELEEVGKYLL 430 440 450 460 470 480 GEDNAIADYH LEWADQLKEK YPRINKEEVN SVVQHEAGQV FARVLEDAGV YKNTPSGHEA 490 FMRFVKSVGI N

References

[1]

"Genome of the bacterium Streptococcus pneumoniae strain R6." Hoskins J., Alborn W.E. Jr., Arnold J., Blaszczak L.C., Burgett S., DeHoff B.S., Estrem S.T., Fritz L., Fu D.-J., Fuller W., Geringer C., Gilmour R., Glass J.S., Khoja H., Kraft A.R., Lagace R.E., LeBlanc D.J., Lee L.N. , Lefkowitz E.J., Lu J., Matsushima P., McAhren S.M., McHenney M., McLeaster K., Mundy C.W., Nicas T.I., Norris F.H., O'Gara M., Peery R.B., Robertson G.T., Rockey P., Sun P.-M., Winkler M.E., Yang Y., Young-Bellido M., Zhao G., Zook C.A., Baltz R.H., Jaskunas S.R., Rosteck P.R. Jr., Skatrud P.L., Glass J.I. J. Bacteriol. 183:5709-5717(2001) [PubMed: 11544234] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-255 / R6.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE007317 Genomic DNA. Translation: AAL00451.1.
PIR	F98077.
RefSeq	NP_359240.1. NC_003098.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q8DNL8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTRT00000015369; EBSTRP00000014765; EBSTRG00000015369.
GeneID	932967.
GenomeReviews	Gene locus spr1648 in contig AE007317_GR.
KEGG	spr:spr1648.
PATRIC	19703324. VBIStrPne107296_1777.
Phylogenomic databases
eggNOG	COG4468.
GeneTree	EBGT00050000027103.
HOGENOM	HBG337915.
OMA	TICHENE.
PhylomeDB	Q8DNL8.
ProtClustDB	PRK05270.
Enzyme and pathway databases
BioCyc	SPNE171101:SPR1648-MONOMER.
Family and domain databases
HAMAP	MF_00571. GalP_UDP_trans. [Tree]
InterPro	IPR000766. GalP_uridyl_Trfase_II. IPR023425. GalP_uridyl_Trfase_II_CS. IPR005850. GalP_Utransf_C. IPR005849. GalP_Utransf_N. [Graphical view]
KO	K00965.
Pfam	PF02744. GalP_UDP_tr_C. 1 hit. PF01087. GalP_UDP_transf. 1 hit. [Graphical view]
PIRSF	PIRSF006005. GalT_BS. 1 hit.
TIGRFAMs	TIGR01239. GalT_2. 1 hit.
PROSITE	PS01163. GAL_P_UDP_TRANSF_II. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GALT1_STRR6

Accession

Primary (citable) accession number: Q8DNL8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 30, 2003
Last sequence update:	March 1, 2003
Last modified:	January 25, 2012
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program