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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Streptococcus pneumoniae (strain ATCC BAA-255 / R6)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. ATP-dependent 6-phosphofructokinase (pfkA)
  4. Fructose-bisphosphate aldolase (fba)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei291Proton donorUniRule annotation1
Active sitei312UniRule annotation1
Active sitei426UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciSPNE171101:G1FZH-1995-MONOMER
UniPathwayiUPA00109; UER00181

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Synonyms:gpi
Ordered Locus Names:spr1882
OrganismiStreptococcus pneumoniae (strain ATCC BAA-255 / R6)
Taxonomic identifieri171101 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000000586 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001807391 – 449Glucose-6-phosphate isomeraseAdd BLAST449

Proteomic databases

PRIDEiQ8DN74

Interactioni

Protein-protein interaction databases

STRINGi171101.spr1882

Structurei

3D structure databases

ProteinModelPortaliQ8DN74
SMRiQ8DN74
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QYV Bacteria
COG0166 LUCA
HOGENOMiHOG000100403
KOiK01810
OMAiVERCKAM

Family and domain databases

CDDicd05015 SIS_PGI_1, 1 hit
cd05016 SIS_PGI_2, 1 hit
HAMAPiMF_00473 G6P_isomerase, 1 hit
InterProiView protein in InterPro
IPR001672 G6P_Isomerase
IPR018189 Phosphoglucose_isomerase_CS
IPR035476 SIS_PGI_1
IPR035482 SIS_PGI_2
PANTHERiPTHR11469 PTHR11469, 1 hit
PfamiView protein in Pfam
PF00342 PGI, 1 hit
PRINTSiPR00662 G6PISOMERASE
PROSITEiView protein in PROSITE
PS00765 P_GLUCOSE_ISOMERASE_1, 1 hit
PS00174 P_GLUCOSE_ISOMERASE_2, 1 hit
PS51463 P_GLUCOSE_ISOMERASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q8DN74-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHIKFDYSK VLDKFVAPHE VEYMQSQVTA ADELIRKGTG AGSDFLGWLD
60 70 80 90 100
LPEKYDREEF DRILKAAEQI KSDSDVLVVI GIGGSYLGAK AAIDFLNHHF
110 120 130 140 150
ANLQTKEERK APQILYAGNS ISSTYLADLV EYVADKDFSV NVISKSGTTT
160 170 180 190 200
EPAIAFRVFK ELLVKKYGQE EANKRIYATT DRQKGAVKVE ADANGWGTFV
210 220 230 240 250
VPDDIGGRFS VLTAVGLLPI AASGADIKAL MEGANAARKD YTSDKISENE
260 270 280 290 300
AYQYAAVRNI LYRKGYATEI LVNYEPSLQY FSEWWKQLAG ESEGKDQKGI
310 320 330 340 350
YPTSANFSTD LHSLGQFIQE GTRIMFETVV RVDKPRKNVL IPTLEEDLDG
360 370 380 390 400
LGYLQGKDVD FVNKKATDGV LLAHTDGDVP NMYVTLPEQD AFTLGYTIYF
410 420 430 440
FELAIALSGY LNAINPFDQP GVEAYKRNMF ALLGKPGFEE LSKELNARL
Length:449
Mass (Da):49,878
Last modified:March 1, 2003 - v1
Checksum:i563518A955D0C1E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE007317 Genomic DNA Translation: AAL00684.1
PIRiG98106
RefSeqiNP_359473.1, NC_003098.1
WP_000018262.1, NC_003098.1

Genome annotation databases

EnsemblBacteriaiAAL00684; AAL00684; spr1882
GeneIDi934060
KEGGispr:spr1882
PATRICifig|171101.6.peg.2031

Similar proteinsi

Entry informationi

Entry nameiG6PI_STRR6
AccessioniPrimary (citable) accession number: Q8DN74
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 23, 2003
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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