Q8DMS9 (LPXD_THEEB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
UDP-3-O-acylglucosamine N-acyltransferase
EC=2.3.1.-

Gene names

Name:	lpxD
Ordered Locus Names:	tll0032

Organism

Thermosynechococcus elongatus (strain BP-1)

Taxonomic identifier

197221 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Thermosynechococcus

Protein attributes

Sequence length	338 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP MF_00523
Catalytic activity	(3R)-3-hydroxyacyl-[acyl-carrier-protein] + UDP-3-O-acyl-alpha-D-glucosamine = UDP-2,3-diacyl-alpha-D-glucosamine + [acyl-carrier-protein]. HAMAP MF_00523
Pathway	Bacterial outer membrane biogenesis; LPS lipid A biosynthesis. HAMAP MF_00523
Subunit structure	Homotrimer By similarity. HAMAP MF_00523
Sequence similarities	Belongs to the transferase hexapeptide repeat family. LpxD subfamily.

Ontologies

Keywords
Biological process	Lipid A biosynthesis Lipid synthesis
Domain	Repeat
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	transferase activity, transferring acyl groups other than amino-acyl groups Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 338	338	UDP-3-O-acylglucosamine N-acyltransferase HAMAP MF_00523		PRO_0000059705
Sites
	Active site	239	1	Proton acceptor By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8DMS9 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: C45EA661C9DA45FF	FASTA	338	35,763
	10 20 30 40 50 60 MRLADVAERF GATLDCPEHG DRPVLGVAPL ETATATDISF LANPKYTALL QTTQAAAVFV 70 80 90 100 110 120 RPDFQGEAAC PLLRVPHPYL AFAKCIEWFY PQPKPVAKIH PTAILGADVV LGAEVTIGAY 130 140 150 160 170 180 TVIGDRVRIG DRTVIDSHCT LYDDVVIGSD CRIYSHCALR ERVQLGDRVI LQNSVVLGSD 190 200 210 220 230 240 GFGYVPLPDG RHYKIPQVGT VVIGNDVEIG AGTTIDRATL GETTVANGTK IDNLTMVAHN 250 260 270 280 290 300 CTIGENAILC AQVGLAGSTH IGNHVVLAGQ VGAAGHLTIG DRTVVSAKSG ISSSVPPDSR 310 320 330 MGGIPAMDQT LYLKVSAAVK QLPDLLKRVR KLEAKVGE

References

[1]

"Complete genome structure of the thermophilic cyanobacterium Thermosynechococcus elongatus BP-1." Nakamura Y., Kaneko T., Sato S., Ikeuchi M., Katoh H., Sasamoto S., Watanabe A., Iriguchi M., Kawashima K., Kimura T., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Nakazaki N., Shimpo S., Sugimoto M. , Takeuchi C., Yamada M., Tabata S. DNA Res. 9:123-130(2002) [PubMed: 12240834] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: BP-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000039 Genomic DNA. Translation: BAC07585.1.
RefSeq	NP_680823.1. NC_004113.1.
3D structure databases
ProteinModelPortal	Q8DMS9.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8DMS9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1010653.
GenomeReviews	Gene locus tll0032 in contig BA000039_GR.
KEGG	tel:tll0032.
NMPDR	fig|197221.1.peg.32.
PATRIC	23925238. VBITheElo119873_0031.
Phylogenomic databases
eggNOG	COG1044.
HOGENOM	HBG469615.
OMA	SYPAKIM.
Enzyme and pathway databases
BioCyc	TELO197221:TLL0032-MONOMER.
Family and domain databases
HAMAP	MF_00523. LpxD. [Tree]
InterPro	IPR001451. Hexapep_transf. IPR011004. Trimer_LpxA-like. IPR007691. UDP-3-O_GlcNAc_AcTrfase. IPR020573. UDP_GlcNAc_AcTrfase_non-rep. [Graphical view]
KO	K02536.
Pfam	PF00132. Hexapep. 5 hits. PF04613. LpxD. 1 hit. [Graphical view]
SUPFAM	SSF51161. Trimer_LpxA_like. 1 hit.
TIGRFAMs	TIGR01853. Lipid_A_lpxD. 1 hit.
PROSITE	PS00101. HEXAPEP_TRANSFERASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LPXD_THEEB

Accession

Primary (citable) accession number: Q8DMS9

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 22, 2003
Last sequence update:	March 1, 2003
Last modified:	January 25, 2012
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program