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Protein

Alanine racemase

Gene

tll0460

Organism
Thermosynechococcus elongatus (strain BP-1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei76 – 761Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei175 – 1751SubstrateUniRule annotation
Active sitei304 – 3041Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei352 – 3521Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:tll0460Imported
OrganismiThermosynechococcus elongatus (strain BP-1)Imported
Taxonomic identifieri197221 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesThermosynechococcus
ProteomesiUP000000440 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei76 – 761N6-(pyridoxal phosphate)lysineUniRule annotation

Proteomic databases

PRIDEiQ8DLM4.

Interactioni

Protein-protein interaction databases

STRINGi197221.tll0460.

Structurei

3D structure databases

ProteinModelPortaliQ8DLM4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000031444.
KOiK01775.
OMAiITMDQLM.
OrthoDBiEOG6PP9NJ.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8DLM4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIYIESQTLS GCRVSHSLRG SYGVRIETTM LSQEQLTSSH ECERAWIEID
60 70 80 90 100
LAALAANTRS LRQWLAPTTE LLAVVKADAY GHGALTVAQT VLAHGATWLG
110 120 130 140 150
VATIPEGIAL RQAGITAPIL VLGSVNLPVQ VQMMAQWQLQ PTLSTPKQAL
160 170 180 190 200
IFSDYADRLR EPLDVHLMID TGMSRLGCPW QDAVGFVQFV QRLPHLRIQG
210 220 230 240 250
IYSHFASADD PDASLMRQQQ AYFEQVWEQI SALGLGPVRR HMANSAATLA
260 270 280 290 300
NRSSHYDMVR IGLSLYGVYP ASHLRGVVPL RPVMQVRSRI TLLKEIPAGT
310 320 330 340 350
GISYGHQFIA PQPMKIAVVG IGYADGVPRL LSNKLEVLVQ GKRLRQVGAI
360 370 380 390 400
TMDQLMIDVS DMDGLQEGDV VTLLGEDGGD CLTVETWAEA LGTITWEILC
410
GFKNRLPRIP VS
Length:412
Mass (Da):45,153
Last modified:March 1, 2003 - v1
Checksum:i629827F652FD161D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000039 Genomic DNA. Translation: BAC08012.1.
RefSeqiNP_681250.2. NC_004113.1.

Genome annotation databases

EnsemblBacteriaiBAC08012; BAC08012; BAC08012.
GeneIDi1012702.
KEGGitel:tll0460.
PATRICi23926164. VBITheElo119873_0485.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000039 Genomic DNA. Translation: BAC08012.1.
RefSeqiNP_681250.2. NC_004113.1.

3D structure databases

ProteinModelPortaliQ8DLM4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi197221.tll0460.

Proteomic databases

PRIDEiQ8DLM4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC08012; BAC08012; BAC08012.
GeneIDi1012702.
KEGGitel:tll0460.
PATRICi23926164. VBITheElo119873_0485.

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000031444.
KOiK01775.
OMAiITMDQLM.
OrthoDBiEOG6PP9NJ.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BP-1Imported.

Entry informationi

Entry nameiQ8DLM4_THEEB
AccessioniPrimary (citable) accession number: Q8DLM4
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2003
Last sequence update: March 1, 2003
Last modified: March 4, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.