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Q8DLK8

- GSA_THEEB

UniProt

Q8DLK8 - GSA_THEEB

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Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Thermosynechococcus elongatus (strain BP-1)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi

GO - Molecular functioni

  1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro
  3. transaminase activity Source: InterPro

GO - Biological processi

  1. chlorophyll biosynthetic process Source: UniProtKB-HAMAP
  2. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Chlorophyll biosynthesis, Porphyrin biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00251; UER00317.
UPA00668.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
Short name:
GSAUniRule annotation
Alternative name(s):
Glutamate-1-semialdehyde aminotransferaseUniRule annotation
Short name:
GSA-ATUniRule annotation
Gene namesi
Name:hemLUniRule annotation
Ordered Locus Names:tlr0479
OrganismiThermosynechococcus elongatus (strain BP-1)
Taxonomic identifieri197221 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesThermosynechococcus
ProteomesiUP000000440: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 437437Glutamate-1-semialdehyde 2,1-aminomutasePRO_0000120460Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei277 – 2771N6-(pyridoxal phosphate)lysineUniRule annotation

Proteomic databases

PRIDEiQ8DLK8.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi197221.tlr0479.

Structurei

Secondary structure

1
437
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi48 – 536Combined sources
Beta strandi55 – 584Combined sources
Beta strandi63 – 686Combined sources
Turni69 – 735Combined sources
Helixi81 – 9111Combined sources
Helixi102 – 11413Combined sources
Beta strandi119 – 1268Combined sources
Helixi127 – 14216Combined sources
Beta strandi146 – 1516Combined sources
Beta strandi188 – 1925Combined sources
Helixi196 – 20510Combined sources
Turni207 – 2093Combined sources
Beta strandi210 – 2156Combined sources
Beta strandi217 – 2193Combined sources
Beta strandi221 – 2233Combined sources
Helixi231 – 24111Combined sources
Beta strandi245 – 2506Combined sources
Turni251 – 2566Combined sources
Helixi261 – 2666Combined sources
Beta strandi271 – 2755Combined sources
Helixi277 – 2804Combined sources
Beta strandi286 – 2905Combined sources
Helixi292 – 2954Combined sources
Helixi314 – 32714Combined sources
Helixi332 – 35221Combined sources
Turni353 – 3553Combined sources
Beta strandi359 – 3635Combined sources
Beta strandi366 – 3738Combined sources
Helixi379 – 3824Combined sources
Helixi387 – 39913Combined sources
Helixi420 – 43415Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CFBX-ray2.85A27-437[»]
ProteinModelPortaliQ8DLK8.
SMRiQ8DLK8. Positions 11-437.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8DLK8.

Family & Domainsi

Sequence similaritiesi

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0001.
HOGENOMiHOG000020210.
KOiK01845.
OMAiRAIKPYP.
OrthoDBiEOG6QVRHN.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_00375. HemL_aminotrans_3.
InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00713. hemL. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8DLK8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRELTLTTTV FQTTKSQEIF AAAQKLMPGG VSSPVRAFKS VGGQPIVFDH
60 70 80 90 100
VKGAHIWDVD GNQYIDYVGS WGPAIVGHAH PEVIDALHAA LEKGTSFGAP
110 120 130 140 150
CLLENILAEM VIAAVPSVEM VRFVNSGTEA CMAVLRLMRA YTQREKVIKF
160 170 180 190 200
EGCYHGHADM FLVKAGSGVA TLGLPDSPGV PKATTAATLT APYNDLEAVS
210 220 230 240 250
RLFEQYPNDI AGVILEPVVG NAGFIPPDAG FLEGLRELTK QYGALLVFDE
260 270 280 290 300
VMTGFRIAYG GAQEKFGVTP DLTTLGKVIG GGLPVGAYGG RAEIMKMVAP
310 320 330 340 350
AGPVYQAGTL SGNPLAMTAG IKTLEILSRP GSYEHLDRIT GKLVQGLLDA
360 370 380 390 400
AREFGHEVCG GHISGMFGLF FTAGPVTNYE QAKQSDLKKF AAFHRGMLEQ
410 420 430
GIYLAPSQFE AGFTSLAHTE ADIERTIAAA RTVLSQL
Length:437
Mass (Da):46,450
Last modified:June 20, 2003 - v2
Checksum:i5FDD56F62A179C23
GO

Sequence cautioni

The sequence BAC08031.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000039 Genomic DNA. Translation: BAC08031.1. Different initiation.
RefSeqiNP_681269.2. NC_004113.1.

Genome annotation databases

EnsemblBacteriaiBAC08031; BAC08031; BAC08031.
GeneIDi1012458.
KEGGitel:tlr0479.
PATRICi23926202. VBITheElo119873_0504.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000039 Genomic DNA. Translation: BAC08031.1 . Different initiation.
RefSeqi NP_681269.2. NC_004113.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2CFB X-ray 2.85 A 27-437 [» ]
ProteinModelPortali Q8DLK8.
SMRi Q8DLK8. Positions 11-437.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 197221.tlr0479.

Proteomic databases

PRIDEi Q8DLK8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC08031 ; BAC08031 ; BAC08031 .
GeneIDi 1012458.
KEGGi tel:tlr0479.
PATRICi 23926202. VBITheElo119873_0504.

Phylogenomic databases

eggNOGi COG0001.
HOGENOMi HOG000020210.
KOi K01845.
OMAi RAIKPYP.
OrthoDBi EOG6QVRHN.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00317 .
UPA00668 .

Miscellaneous databases

EvolutionaryTracei Q8DLK8.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPi MF_00375. HemL_aminotrans_3.
InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR00713. hemL. 1 hit.
PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BP-1.

Entry informationi

Entry nameiGSA_THEEB
AccessioniPrimary (citable) accession number: Q8DLK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: June 20, 2003
Last modified: November 26, 2014
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3