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Q8DLK8

- GSA_THEEB

UniProt

Q8DLK8 - GSA_THEEB

Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Thermosynechococcus elongatus (strain BP-1)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 2 (20 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: InterPro
    3. transaminase activity Source: InterPro

    GO - Biological processi

    1. chlorophyll biosynthetic process Source: UniProtKB-HAMAP
    2. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Chlorophyll biosynthesis, Porphyrin biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    UniPathwayiUPA00251; UER00317.
    UPA00668.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
    Short name:
    GSAUniRule annotation
    Alternative name(s):
    Glutamate-1-semialdehyde aminotransferaseUniRule annotation
    Short name:
    GSA-ATUniRule annotation
    Gene namesi
    Name:hemLUniRule annotation
    Ordered Locus Names:tlr0479
    OrganismiThermosynechococcus elongatus (strain BP-1)
    Taxonomic identifieri197221 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesThermosynechococcus
    ProteomesiUP000000440: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 437437Glutamate-1-semialdehyde 2,1-aminomutasePRO_0000120460Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei277 – 2771N6-(pyridoxal phosphate)lysineUniRule annotation

    Proteomic databases

    PRIDEiQ8DLK8.

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi197221.tlr0479.

    Structurei

    Secondary structure

    1
    437
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi48 – 536
    Beta strandi55 – 584
    Beta strandi63 – 686
    Turni69 – 735
    Helixi81 – 9111
    Helixi102 – 11413
    Beta strandi119 – 1268
    Helixi127 – 14216
    Beta strandi146 – 1516
    Beta strandi188 – 1925
    Helixi196 – 20510
    Turni207 – 2093
    Beta strandi210 – 2156
    Beta strandi217 – 2193
    Beta strandi221 – 2233
    Helixi231 – 24111
    Beta strandi245 – 2506
    Turni251 – 2566
    Helixi261 – 2666
    Beta strandi271 – 2755
    Helixi277 – 2804
    Beta strandi286 – 2905
    Helixi292 – 2954
    Helixi314 – 32714
    Helixi332 – 35221
    Turni353 – 3553
    Beta strandi359 – 3635
    Beta strandi366 – 3738
    Helixi379 – 3824
    Helixi387 – 39913
    Helixi420 – 43415

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2CFBX-ray2.85A27-437[»]
    ProteinModelPortaliQ8DLK8.
    SMRiQ8DLK8. Positions 11-437.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8DLK8.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0001.
    HOGENOMiHOG000020210.
    KOiK01845.
    OMAiRAIKPYP.
    OrthoDBiEOG6QVRHN.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPiMF_00375. HemL_aminotrans_3.
    InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR11986. PTHR11986. 1 hit.
    PfamiPF00202. Aminotran_3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR00713. hemL. 1 hit.
    PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8DLK8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRELTLTTTV FQTTKSQEIF AAAQKLMPGG VSSPVRAFKS VGGQPIVFDH    50
    VKGAHIWDVD GNQYIDYVGS WGPAIVGHAH PEVIDALHAA LEKGTSFGAP 100
    CLLENILAEM VIAAVPSVEM VRFVNSGTEA CMAVLRLMRA YTQREKVIKF 150
    EGCYHGHADM FLVKAGSGVA TLGLPDSPGV PKATTAATLT APYNDLEAVS 200
    RLFEQYPNDI AGVILEPVVG NAGFIPPDAG FLEGLRELTK QYGALLVFDE 250
    VMTGFRIAYG GAQEKFGVTP DLTTLGKVIG GGLPVGAYGG RAEIMKMVAP 300
    AGPVYQAGTL SGNPLAMTAG IKTLEILSRP GSYEHLDRIT GKLVQGLLDA 350
    AREFGHEVCG GHISGMFGLF FTAGPVTNYE QAKQSDLKKF AAFHRGMLEQ 400
    GIYLAPSQFE AGFTSLAHTE ADIERTIAAA RTVLSQL 437
    Length:437
    Mass (Da):46,450
    Last modified:June 20, 2003 - v2
    Checksum:i5FDD56F62A179C23
    GO

    Sequence cautioni

    The sequence BAC08031.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000039 Genomic DNA. Translation: BAC08031.1. Different initiation.
    RefSeqiNP_681269.2. NC_004113.1.

    Genome annotation databases

    EnsemblBacteriaiBAC08031; BAC08031; BAC08031.
    GeneIDi1012458.
    KEGGitel:tlr0479.
    PATRICi23926202. VBITheElo119873_0504.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000039 Genomic DNA. Translation: BAC08031.1 . Different initiation.
    RefSeqi NP_681269.2. NC_004113.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2CFB X-ray 2.85 A 27-437 [» ]
    ProteinModelPortali Q8DLK8.
    SMRi Q8DLK8. Positions 11-437.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 197221.tlr0479.

    Proteomic databases

    PRIDEi Q8DLK8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC08031 ; BAC08031 ; BAC08031 .
    GeneIDi 1012458.
    KEGGi tel:tlr0479.
    PATRICi 23926202. VBITheElo119873_0504.

    Phylogenomic databases

    eggNOGi COG0001.
    HOGENOMi HOG000020210.
    KOi K01845.
    OMAi RAIKPYP.
    OrthoDBi EOG6QVRHN.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00317 .
    UPA00668 .

    Miscellaneous databases

    EvolutionaryTracei Q8DLK8.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPi MF_00375. HemL_aminotrans_3.
    InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR11986. PTHR11986. 1 hit.
    Pfami PF00202. Aminotran_3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR00713. hemL. 1 hit.
    PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BP-1.

    Entry informationi

    Entry nameiGSA_THEEB
    AccessioniPrimary (citable) accession number: Q8DLK8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2003
    Last sequence update: June 20, 2003
    Last modified: October 1, 2014
    This is version 85 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3