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Q8DLK8

- GSA_THEEB

UniProt

Q8DLK8 - GSA_THEEB

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Protein
Glutamate-1-semialdehyde 2,1-aminomutase
Gene
hemL, tlr0479
Organism
Thermosynechococcus elongatus (strain BP-1)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro
  3. transaminase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. chlorophyll biosynthetic process Source: UniProtKB-HAMAP
  2. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Chlorophyll biosynthesis, Porphyrin biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00251; UER00317.
UPA00668.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase (EC:5.4.3.8)
Short name:
GSA
Alternative name(s):
Glutamate-1-semialdehyde aminotransferase
Short name:
GSA-AT
Gene namesi
Name:hemL
Ordered Locus Names:tlr0479
OrganismiThermosynechococcus elongatus (strain BP-1)
Taxonomic identifieri197221 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesThermosynechococcus
ProteomesiUP000000440: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 437437Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation
PRO_0000120460Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei277 – 2771N6-(pyridoxal phosphate)lysine By similarity

Proteomic databases

PRIDEiQ8DLK8.

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi197221.tlr0479.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi48 – 536
Beta strandi55 – 584
Beta strandi63 – 686
Turni69 – 735
Helixi81 – 9111
Helixi102 – 11413
Beta strandi119 – 1268
Helixi127 – 14216
Beta strandi146 – 1516
Beta strandi188 – 1925
Helixi196 – 20510
Turni207 – 2093
Beta strandi210 – 2156
Beta strandi217 – 2193
Beta strandi221 – 2233
Helixi231 – 24111
Beta strandi245 – 2506
Turni251 – 2566
Helixi261 – 2666
Beta strandi271 – 2755
Helixi277 – 2804
Beta strandi286 – 2905
Helixi292 – 2954
Helixi314 – 32714
Helixi332 – 35221
Turni353 – 3553
Beta strandi359 – 3635
Beta strandi366 – 3738
Helixi379 – 3824
Helixi387 – 39913
Helixi420 – 43415

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CFBX-ray2.85A27-437[»]
ProteinModelPortaliQ8DLK8.
SMRiQ8DLK8. Positions 11-437.

Miscellaneous databases

EvolutionaryTraceiQ8DLK8.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0001.
HOGENOMiHOG000020210.
KOiK01845.
OMAiRAIKPYP.
OrthoDBiEOG6QVRHN.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_00375. HemL_aminotrans_3.
InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00713. hemL. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8DLK8-1 [UniParc]FASTAAdd to Basket

« Hide

MRELTLTTTV FQTTKSQEIF AAAQKLMPGG VSSPVRAFKS VGGQPIVFDH    50
VKGAHIWDVD GNQYIDYVGS WGPAIVGHAH PEVIDALHAA LEKGTSFGAP 100
CLLENILAEM VIAAVPSVEM VRFVNSGTEA CMAVLRLMRA YTQREKVIKF 150
EGCYHGHADM FLVKAGSGVA TLGLPDSPGV PKATTAATLT APYNDLEAVS 200
RLFEQYPNDI AGVILEPVVG NAGFIPPDAG FLEGLRELTK QYGALLVFDE 250
VMTGFRIAYG GAQEKFGVTP DLTTLGKVIG GGLPVGAYGG RAEIMKMVAP 300
AGPVYQAGTL SGNPLAMTAG IKTLEILSRP GSYEHLDRIT GKLVQGLLDA 350
AREFGHEVCG GHISGMFGLF FTAGPVTNYE QAKQSDLKKF AAFHRGMLEQ 400
GIYLAPSQFE AGFTSLAHTE ADIERTIAAA RTVLSQL 437
Length:437
Mass (Da):46,450
Last modified:June 20, 2003 - v2
Checksum:i5FDD56F62A179C23
GO

Sequence cautioni

The sequence BAC08031.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000039 Genomic DNA. Translation: BAC08031.1. Different initiation.
RefSeqiNP_681269.2. NC_004113.1.

Genome annotation databases

EnsemblBacteriaiBAC08031; BAC08031; BAC08031.
GeneIDi1012458.
KEGGitel:tlr0479.
PATRICi23926202. VBITheElo119873_0504.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000039 Genomic DNA. Translation: BAC08031.1 . Different initiation.
RefSeqi NP_681269.2. NC_004113.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2CFB X-ray 2.85 A 27-437 [» ]
ProteinModelPortali Q8DLK8.
SMRi Q8DLK8. Positions 11-437.
ModBasei Search...

Protein-protein interaction databases

STRINGi 197221.tlr0479.

Proteomic databases

PRIDEi Q8DLK8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC08031 ; BAC08031 ; BAC08031 .
GeneIDi 1012458.
KEGGi tel:tlr0479.
PATRICi 23926202. VBITheElo119873_0504.

Phylogenomic databases

eggNOGi COG0001.
HOGENOMi HOG000020210.
KOi K01845.
OMAi RAIKPYP.
OrthoDBi EOG6QVRHN.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00317 .
UPA00668 .

Miscellaneous databases

EvolutionaryTracei Q8DLK8.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPi MF_00375. HemL_aminotrans_3.
InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR00713. hemL. 1 hit.
PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BP-1.

Entry informationi

Entry nameiGSA_THEEB
AccessioniPrimary (citable) accession number: Q8DLK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: June 20, 2003
Last modified: May 14, 2014
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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