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Protein

1,4-alpha-glucan branching enzyme GlgB

Gene

glgB

Organism
Thermosynechococcus elongatus (strain BP-1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.UniRule annotation

Catalytic activityi

Transfers a segment of a (1->4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei431 – 4311NucleophileUniRule annotation
Active sitei484 – 4841Proton donorUniRule annotation

GO - Molecular functioni

  1. 1,4-alpha-glucan branching enzyme activity Source: UniProtKB-HAMAP
  2. cation binding Source: InterPro
  3. hydrolase activity, hydrolyzing O-glycosyl compounds Source: InterPro

GO - Biological processi

  1. glycogen biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Carbohydrate metabolism, Glycogen biosynthesis, Glycogen metabolism

Enzyme and pathway databases

UniPathwayiUPA00164.

Protein family/group databases

CAZyiCBM48. Carbohydrate-Binding Module Family 48.
GH13. Glycoside Hydrolase Family 13.

Names & Taxonomyi

Protein namesi
Recommended name:
1,4-alpha-glucan branching enzyme GlgBUniRule annotation (EC:2.4.1.18UniRule annotation)
Alternative name(s):
1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferaseUniRule annotation
Alpha-(1->4)-glucan branching enzymeUniRule annotation
Glycogen branching enzymeUniRule annotation
Short name:
BEUniRule annotation
Gene namesi
Name:glgBUniRule annotation
Ordered Locus Names:tll0578
OrganismiThermosynechococcus elongatus (strain BP-1)
Taxonomic identifieri197221 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesThermosynechococcus
ProteomesiUP000000440: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7667661,4-alpha-glucan branching enzyme GlgBPRO_0000188754Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi197221.tll0578.

Structurei

3D structure databases

ProteinModelPortaliQ8DLB8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0296.
HOGENOMiHOG000283037.
KOiK00700.
OMAiQSIAFER.
OrthoDBiEOG6JX7GT.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
2.60.40.1180. 1 hit.
3.20.20.80. 1 hit.
HAMAPiMF_00685. GlgB.
InterProiIPR006048. A-amylase_b_C.
IPR006407. GlgB.
IPR015902. Glyco_hydro_13.
IPR013780. Glyco_hydro_13_b.
IPR006047. Glyco_hydro_13_cat_dom.
IPR004193. Glyco_hydro_13_N.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
[Graphical view]
PANTHERiPTHR10357. PTHR10357. 1 hit.
PfamiPF00128. Alpha-amylase. 1 hit.
PF02806. Alpha-amylase_C. 1 hit.
PF02922. CBM_48. 2 hits.
[Graphical view]
PIRSFiPIRSF000463. GlgB. 1 hit.
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF81296. SSF81296. 2 hits.
TIGRFAMsiTIGR01515. branching_enzym. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8DLB8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVSPEQIDR IVSNQHHDPF EILGCHQIQQ NGQSVWAVRA YLPNAERVSV
60 70 80 90 100
LCPEQRQEYP MTPVHHPHFF ECHIPVAELN NYQLKIYENG HERVIYDPYA
110 120 130 140 150
FRSPKLTDFD IHLFAEGNHH RIYEKLGAHL LTVDGVEGVY FAVWAPNARN
160 170 180 190 200
VSVIGDFNHW DGRKHQMARR GNGIWELFIP GLSVGERYKY EIKNQEGHIY
210 220 230 240 250
EKSDPYGFYQ EPRPKTASIV TDLNSYEWGD SDWLEKRRHT DPLNQPISVY
260 270 280 290 300
EVHLGSWLHA SMEDPPIGAD GQPQEPVQAA ELKPWARFLT YRELAAKLIP
310 320 330 340 350
YVKELGYTHI ELLPVAEHPF DGSWGYQVTG YYAPTSRYGS PHDFMYFVDQ
360 370 380 390 400
CHQNGIGVIV DWVPGHFPKD GHGLAFFDGT HLYEHADPRK GEHKEWGTLV
410 420 430 440 450
FNYGRHEVRN FLVANALFWF DKYHIDGIRV DAVASMLYLD YGRKEGEWIP
460 470 480 490 500
NEYGGRENLE AANFLRQVNH VIFSYFPGIL SIAEESTAWP MVSWPTYMGG
510 520 530 540 550
LGFNLKWNMG WMHDMLDYFS MDPWFRQFHH NNVTFSMWYH HSENFMLALS
560 570 580 590 600
HDEVVHGKSH IIGKMPGDRW QKFANLRCLF AYMFTHPGKK TMFMGMEFAQ
610 620 630 640 650
WSEWNVWSDL EWHLLQYEPH QQIKRFFGDL NHLYRSQPAL YSQDFKQEGF
660 670 680 690 700
EWIDCSDNRH SVVSFIRWDK DYQDFVVVVC NFTPQPHSHY RIGVPEHGFY
710 720 730 740 750
RELFNSDARE YGGSNMGNLG GKWADEWPYH QRRYSLDLCL PPLAVLILKL
760
DREKTVAERA RYNLQS
Length:766
Mass (Da):89,885
Last modified:March 1, 2003 - v1
Checksum:i42ED3BCF9036035E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000039 Genomic DNA. Translation: BAC08130.1.
RefSeqiNP_681368.1. NC_004113.1.
WP_011056426.1. NC_004113.1.

Genome annotation databases

EnsemblBacteriaiBAC08130; BAC08130; BAC08130.
GeneIDi1012543.
KEGGitel:tll0578.
PATRICi23926416. VBITheElo119873_0610.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000039 Genomic DNA. Translation: BAC08130.1.
RefSeqiNP_681368.1. NC_004113.1.
WP_011056426.1. NC_004113.1.

3D structure databases

ProteinModelPortaliQ8DLB8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi197221.tll0578.

Protein family/group databases

CAZyiCBM48. Carbohydrate-Binding Module Family 48.
GH13. Glycoside Hydrolase Family 13.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC08130; BAC08130; BAC08130.
GeneIDi1012543.
KEGGitel:tll0578.
PATRICi23926416. VBITheElo119873_0610.

Phylogenomic databases

eggNOGiCOG0296.
HOGENOMiHOG000283037.
KOiK00700.
OMAiQSIAFER.
OrthoDBiEOG6JX7GT.

Enzyme and pathway databases

UniPathwayiUPA00164.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
2.60.40.1180. 1 hit.
3.20.20.80. 1 hit.
HAMAPiMF_00685. GlgB.
InterProiIPR006048. A-amylase_b_C.
IPR006407. GlgB.
IPR015902. Glyco_hydro_13.
IPR013780. Glyco_hydro_13_b.
IPR006047. Glyco_hydro_13_cat_dom.
IPR004193. Glyco_hydro_13_N.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
[Graphical view]
PANTHERiPTHR10357. PTHR10357. 1 hit.
PfamiPF00128. Alpha-amylase. 1 hit.
PF02806. Alpha-amylase_C. 1 hit.
PF02922. CBM_48. 2 hits.
[Graphical view]
PIRSFiPIRSF000463. GlgB. 1 hit.
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF81296. SSF81296. 2 hits.
TIGRFAMsiTIGR01515. branching_enzym. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BP-1.

Entry informationi

Entry nameiGLGB_THEEB
AccessioniPrimary (citable) accession number: Q8DLB8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 15, 2003
Last sequence update: March 1, 2003
Last modified: March 4, 2015
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.