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Q8DKS3 (AROB_THEEB) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-dehydroquinate synthase
EC=4.2.3.4
Gene names
Name:aroB
Ordered Locus Names:tlr0784
OrganismThermosynechococcus elongatus (strain BP-1)
Taxonomic identifier197221 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Chroococcales › Thermosynechococcus

Protein attributes

Sequence length368 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110

Cofactor

NAD By similarity. HAMAP MF_00110

Divalent metal cations By similarity. HAMAP MF_00110

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110

Subunit structure

Monomer By similarity. HAMAP MF_00110

Subcellular location

Cytoplasm Probable HAMAP MF_00110.

Sequence similarities

Belongs to the dehydroquinate synthase family.

Sequence caution

The sequence BAC08335.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-dehydroquinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3683683-dehydroquinate synthase HAMAP MF_00110
PRO_0000140798

Sequences

Sequence LengthMass (Da)Tools
Q8DKS3 [UniParc].

Last modified December 15, 2003. Version 2.
Checksum: 3A6F35A28A259897

FASTA36839,775
        10         20         30         40         50         60 
MTTLIPVPLG EHSYRIAIGA NTRRQLPALL AAYTPLTPKA PALIVSNPQI WRHYGTDVQG 

        70         80         90        100        110        120 
ALTQAGWQVT PCILPAGERY KTLRTVEKIY DAALSQRLER GSTLFALGGG VIGDMTGFAA 

       130        140        150        160        170        180 
ATWLRGIAVV QIPTSLLAMV DAAIGGKTGV NHPQGKNLIG AFHQPRLVVI DPDVLATLPP 

       190        200        210        220        230        240 
REFRAGMAEV IKYGVIWDAE LFHLLSQLPR LDCMGALPSE QFIQVLRRSC QAKVDVVSKD 

       250        260        270        280        290        300 
EREAGLRAIL NYGHTIGHAL ESIGNYRLLN HGEAVAIGMI AAGELAVALG YWSAEAAAAQ 

       310        320        330        340        350        360 
RALILKAKLP TTIPPHFDVE GLLALLQHDK KVQAQNVRFI LPTAIGHGQI CDQVPAELIR 


ETLHRLQA

« Hide

References

[1]"Complete genome structure of the thermophilic cyanobacterium Thermosynechococcus elongatus BP-1."
Nakamura Y., Kaneko T., Sato S., Ikeuchi M., Katoh H., Sasamoto S., Watanabe A., Iriguchi M., Kawashima K., Kimura T., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Nakazaki N., Shimpo S., Sugimoto M. expand/collapse author list , Takeuchi C., Yamada M., Tabata S.
DNA Res. 9:123-130(2002) [PubMed: 12240834] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: BP-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000039 Genomic DNA. Translation: BAC08335.1. Different initiation.
RefSeqNP_681573.2. NC_004113.1.

3D structure databases

ProteinModelPortalQ8DKS3.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ8DKS3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1011723.
GenomeReviewsGene locus tlr0784 in contig BA000039_GR.
KEGGtel:tlr0784.
NMPDRfig|197221.1.peg.782.
PATRIC23926846. VBITheElo119873_0823.

Phylogenomic databases

eggNOGCOG0337.
HOGENOMHBG632303.
OMAMADEHEQ.
ProtClustDBPRK00002.

Enzyme and pathway databases

BioCycTELO197221:TLR0784-MONOMER.

Family and domain databases

HAMAPMF_00110. DHQ_synthase.
[Tree]
InterProIPR016037. DHQ_synth_AroB.
[Graphical view]
KOK01735.
PANTHERPTHR21090:SF1. DHQ_synth_AroB. 1 hit.
PIRSFPIRSF001455. DHQ_synth. 1 hit.
TIGRFAMsTIGR01357. AroB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROB_THEEB
AccessionPrimary (citable) accession number: Q8DKS3
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: December 15, 2003
Last modified: January 25, 2012
This is version 62 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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