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Q8DKM1

- PDXJ_THEEB

UniProt

Q8DKM1 - PDXJ_THEEB

Protein

Pyridoxine 5'-phosphate synthase

Gene

pdxJ

Organism
Thermosynechococcus elongatus (strain BP-1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.UniRule annotation

    Catalytic activityi

    1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = pyridoxine 5'-phosphate + phosphate + 2 H2O.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei7 – 713-amino-2-oxopropyl phosphateUniRule annotation
    Binding sitei18 – 1813-amino-2-oxopropyl phosphateUniRule annotation
    Active sitei43 – 431Proton acceptorUniRule annotation
    Binding sitei45 – 4511-deoxy-D-xylulose 5-phosphateUniRule annotation
    Binding sitei50 – 5011-deoxy-D-xylulose 5-phosphateUniRule annotation
    Active sitei70 – 701Proton acceptorUniRule annotation
    Binding sitei100 – 10011-deoxy-D-xylulose 5-phosphateUniRule annotation
    Sitei151 – 1511Transition state stabilizerUniRule annotation
    Active sitei191 – 1911Proton donorUniRule annotation
    Binding sitei192 – 19213-amino-2-oxopropyl phosphate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. pyridoxine 5'-phosphate synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. pyridoxine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Pyridoxine biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00244; UER00313.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyridoxine 5'-phosphate synthaseUniRule annotation (EC:2.6.99.2UniRule annotation)
    Short name:
    PNP synthaseUniRule annotation
    Gene namesi
    Name:pdxJUniRule annotation
    Ordered Locus Names:tlr0838
    OrganismiThermosynechococcus elongatus (strain BP-1)
    Taxonomic identifieri197221 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesThermosynechococcus
    ProteomesiUP000000440: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 238238Pyridoxine 5'-phosphate synthasePRO_0000190132Add
    BLAST

    Interactioni

    Subunit structurei

    Homooctamer; tetramer of dimers.UniRule annotation

    Protein-protein interaction databases

    STRINGi197221.tlr0838.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8DKM1.
    SMRiQ8DKM1. Positions 4-236.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni9 – 1021-deoxy-D-xylulose 5-phosphate bindingUniRule annotation
    Regioni213 – 21423-amino-2-oxopropyl phosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the PNP synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0854.
    HOGENOMiHOG000258094.
    KOiK03474.
    OMAiVPETRQE.
    OrthoDBiEOG6M9F0H.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_00279. PdxJ.
    InterProiIPR013785. Aldolase_TIM.
    IPR004569. PyrdxlP_synth_PdxJ.
    [Graphical view]
    PfamiPF03740. PdxJ. 1 hit.
    [Graphical view]
    SUPFAMiSSF63892. SSF63892. 1 hit.
    TIGRFAMsiTIGR00559. pdxJ. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8DKM1-1 [UniParc]FASTAAdd to Basket

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    MATLGVNIDH VATIRQARRT VEPDPVAAAL LAELGGADGI TVHLREDRRH    50
    IQERDVRLLR QTVRTHLNLE MAATPEMVAI ALDIRPDYVT LVPERREEVT 100
    TEGGLDVVSQ QEPLTQVVQT LQGAGIPVSL FIDADPTQLA AAAKTTAQFI 150
    ELHTGRYAEA KGEVAQQREL AILADGVQQA KALGLRVNAG HGLTYSNVGA 200
    IARLEGIEEL NIGHTIISRA VLVGMVQAVR DMKALISP 238
    Length:238
    Mass (Da):25,658
    Last modified:March 1, 2003 - v1
    Checksum:i6B5C6061C59D65DD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000039 Genomic DNA. Translation: BAC08390.1.
    RefSeqiNP_681628.1. NC_004113.1.
    WP_011056682.1. NC_004113.1.

    Genome annotation databases

    EnsemblBacteriaiBAC08390; BAC08390; BAC08390.
    GeneIDi1011556.
    KEGGitel:tlr0838.
    PATRICi23926966. VBITheElo119873_0883.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000039 Genomic DNA. Translation: BAC08390.1 .
    RefSeqi NP_681628.1. NC_004113.1.
    WP_011056682.1. NC_004113.1.

    3D structure databases

    ProteinModelPortali Q8DKM1.
    SMRi Q8DKM1. Positions 4-236.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 197221.tlr0838.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC08390 ; BAC08390 ; BAC08390 .
    GeneIDi 1011556.
    KEGGi tel:tlr0838.
    PATRICi 23926966. VBITheElo119873_0883.

    Phylogenomic databases

    eggNOGi COG0854.
    HOGENOMi HOG000258094.
    KOi K03474.
    OMAi VPETRQE.
    OrthoDBi EOG6M9F0H.

    Enzyme and pathway databases

    UniPathwayi UPA00244 ; UER00313 .

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_00279. PdxJ.
    InterProi IPR013785. Aldolase_TIM.
    IPR004569. PyrdxlP_synth_PdxJ.
    [Graphical view ]
    Pfami PF03740. PdxJ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF63892. SSF63892. 1 hit.
    TIGRFAMsi TIGR00559. pdxJ. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BP-1.

    Entry informationi

    Entry nameiPDXJ_THEEB
    AccessioniPrimary (citable) accession number: Q8DKM1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 30, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3