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Q8DKM1

- PDXJ_THEEB

UniProt

Q8DKM1 - PDXJ_THEEB

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Protein

Pyridoxine 5'-phosphate synthase

Gene

pdxJ

Organism
Thermosynechococcus elongatus (strain BP-1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.UniRule annotation

Catalytic activityi

1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = pyridoxine 5'-phosphate + phosphate + 2 H2O.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei7 – 713-amino-2-oxopropyl phosphateUniRule annotation
Binding sitei18 – 1813-amino-2-oxopropyl phosphateUniRule annotation
Active sitei43 – 431Proton acceptorUniRule annotation
Binding sitei45 – 4511-deoxy-D-xylulose 5-phosphateUniRule annotation
Binding sitei50 – 5011-deoxy-D-xylulose 5-phosphateUniRule annotation
Active sitei70 – 701Proton acceptorUniRule annotation
Binding sitei100 – 10011-deoxy-D-xylulose 5-phosphateUniRule annotation
Sitei151 – 1511Transition state stabilizerUniRule annotation
Active sitei191 – 1911Proton donorUniRule annotation
Binding sitei192 – 19213-amino-2-oxopropyl phosphate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. pyridoxine 5'-phosphate synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. pyridoxine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Pyridoxine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00244; UER00313.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyridoxine 5'-phosphate synthaseUniRule annotation (EC:2.6.99.2UniRule annotation)
Short name:
PNP synthaseUniRule annotation
Gene namesi
Name:pdxJUniRule annotation
Ordered Locus Names:tlr0838
OrganismiThermosynechococcus elongatus (strain BP-1)
Taxonomic identifieri197221 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesThermosynechococcus
ProteomesiUP000000440: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 238238Pyridoxine 5'-phosphate synthasePRO_0000190132Add
BLAST

Interactioni

Subunit structurei

Homooctamer; tetramer of dimers.UniRule annotation

Protein-protein interaction databases

STRINGi197221.tlr0838.

Structurei

3D structure databases

ProteinModelPortaliQ8DKM1.
SMRiQ8DKM1. Positions 4-236.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni9 – 1021-deoxy-D-xylulose 5-phosphate bindingUniRule annotation
Regioni213 – 21423-amino-2-oxopropyl phosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the PNP synthase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0854.
HOGENOMiHOG000258094.
KOiK03474.
OMAiVPETRQE.
OrthoDBiEOG6M9F0H.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00279. PdxJ.
InterProiIPR013785. Aldolase_TIM.
IPR004569. PyrdxlP_synth_PdxJ.
[Graphical view]
PfamiPF03740. PdxJ. 1 hit.
[Graphical view]
SUPFAMiSSF63892. SSF63892. 1 hit.
TIGRFAMsiTIGR00559. pdxJ. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8DKM1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATLGVNIDH VATIRQARRT VEPDPVAAAL LAELGGADGI TVHLREDRRH
60 70 80 90 100
IQERDVRLLR QTVRTHLNLE MAATPEMVAI ALDIRPDYVT LVPERREEVT
110 120 130 140 150
TEGGLDVVSQ QEPLTQVVQT LQGAGIPVSL FIDADPTQLA AAAKTTAQFI
160 170 180 190 200
ELHTGRYAEA KGEVAQQREL AILADGVQQA KALGLRVNAG HGLTYSNVGA
210 220 230
IARLEGIEEL NIGHTIISRA VLVGMVQAVR DMKALISP
Length:238
Mass (Da):25,658
Last modified:March 1, 2003 - v1
Checksum:i6B5C6061C59D65DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000039 Genomic DNA. Translation: BAC08390.1.
RefSeqiNP_681628.1. NC_004113.1.
WP_011056682.1. NC_004113.1.

Genome annotation databases

EnsemblBacteriaiBAC08390; BAC08390; BAC08390.
GeneIDi1011556.
KEGGitel:tlr0838.
PATRICi23926966. VBITheElo119873_0883.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000039 Genomic DNA. Translation: BAC08390.1 .
RefSeqi NP_681628.1. NC_004113.1.
WP_011056682.1. NC_004113.1.

3D structure databases

ProteinModelPortali Q8DKM1.
SMRi Q8DKM1. Positions 4-236.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 197221.tlr0838.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC08390 ; BAC08390 ; BAC08390 .
GeneIDi 1011556.
KEGGi tel:tlr0838.
PATRICi 23926966. VBITheElo119873_0883.

Phylogenomic databases

eggNOGi COG0854.
HOGENOMi HOG000258094.
KOi K03474.
OMAi VPETRQE.
OrthoDBi EOG6M9F0H.

Enzyme and pathway databases

UniPathwayi UPA00244 ; UER00313 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00279. PdxJ.
InterProi IPR013785. Aldolase_TIM.
IPR004569. PyrdxlP_synth_PdxJ.
[Graphical view ]
Pfami PF03740. PdxJ. 1 hit.
[Graphical view ]
SUPFAMi SSF63892. SSF63892. 1 hit.
TIGRFAMsi TIGR00559. pdxJ. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BP-1.

Entry informationi

Entry nameiPDXJ_THEEB
AccessioniPrimary (citable) accession number: Q8DKM1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: March 1, 2003
Last modified: November 26, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3