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Q8DKM1

- PDXJ_THEEB

UniProt

Q8DKM1 - PDXJ_THEEB

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Protein

Pyridoxine 5'-phosphate synthase

Gene
pdxJ, tlr0838
Organism
Thermosynechococcus elongatus (strain BP-1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate By similarity.UniRule annotation

Catalytic activityi

1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = pyridoxine 5'-phosphate + phosphate + 2 H2O.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei7 – 713-amino-2-oxopropyl phosphate By similarity
Binding sitei18 – 1813-amino-2-oxopropyl phosphate By similarity
Active sitei43 – 431Proton acceptor By similarity
Binding sitei45 – 4511-deoxy-D-xylulose 5-phosphate By similarity
Binding sitei50 – 5011-deoxy-D-xylulose 5-phosphate By similarity
Active sitei70 – 701Proton acceptor By similarity
Binding sitei100 – 10011-deoxy-D-xylulose 5-phosphate By similarity
Sitei151 – 1511Transition state stabilizer By similarity
Active sitei191 – 1911Proton donor By similarity
Binding sitei192 – 19213-amino-2-oxopropyl phosphate; via amide nitrogen By similarity

GO - Molecular functioni

  1. pyridoxine 5'-phosphate synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. pyridoxine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Pyridoxine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00244; UER00313.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyridoxine 5'-phosphate synthase (EC:2.6.99.2)
Short name:
PNP synthase
Gene namesi
Name:pdxJ
Ordered Locus Names:tlr0838
OrganismiThermosynechococcus elongatus (strain BP-1)
Taxonomic identifieri197221 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesThermosynechococcus
ProteomesiUP000000440: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 238238Pyridoxine 5'-phosphate synthaseUniRule annotationPRO_0000190132Add
BLAST

Interactioni

Subunit structurei

Homooctamer; tetramer of dimers By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi197221.tlr0838.

Structurei

3D structure databases

ProteinModelPortaliQ8DKM1.
SMRiQ8DKM1. Positions 4-236.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni9 – 1021-deoxy-D-xylulose 5-phosphate binding By similarity
Regioni213 – 21423-amino-2-oxopropyl phosphate binding By similarity

Sequence similaritiesi

Belongs to the PNP synthase family.

Phylogenomic databases

eggNOGiCOG0854.
HOGENOMiHOG000258094.
KOiK03474.
OMAiVPETRQE.
OrthoDBiEOG6M9F0H.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00279. PdxJ.
InterProiIPR013785. Aldolase_TIM.
IPR004569. PyrdxlP_synth_PdxJ.
[Graphical view]
PfamiPF03740. PdxJ. 1 hit.
[Graphical view]
SUPFAMiSSF63892. SSF63892. 1 hit.
TIGRFAMsiTIGR00559. pdxJ. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8DKM1-1 [UniParc]FASTAAdd to Basket

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MATLGVNIDH VATIRQARRT VEPDPVAAAL LAELGGADGI TVHLREDRRH    50
IQERDVRLLR QTVRTHLNLE MAATPEMVAI ALDIRPDYVT LVPERREEVT 100
TEGGLDVVSQ QEPLTQVVQT LQGAGIPVSL FIDADPTQLA AAAKTTAQFI 150
ELHTGRYAEA KGEVAQQREL AILADGVQQA KALGLRVNAG HGLTYSNVGA 200
IARLEGIEEL NIGHTIISRA VLVGMVQAVR DMKALISP 238
Length:238
Mass (Da):25,658
Last modified:March 1, 2003 - v1
Checksum:i6B5C6061C59D65DD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000039 Genomic DNA. Translation: BAC08390.1.
RefSeqiNP_681628.1. NC_004113.1.
WP_011056682.1. NC_004113.1.

Genome annotation databases

EnsemblBacteriaiBAC08390; BAC08390; BAC08390.
GeneIDi1011556.
KEGGitel:tlr0838.
PATRICi23926966. VBITheElo119873_0883.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000039 Genomic DNA. Translation: BAC08390.1 .
RefSeqi NP_681628.1. NC_004113.1.
WP_011056682.1. NC_004113.1.

3D structure databases

ProteinModelPortali Q8DKM1.
SMRi Q8DKM1. Positions 4-236.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 197221.tlr0838.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC08390 ; BAC08390 ; BAC08390 .
GeneIDi 1011556.
KEGGi tel:tlr0838.
PATRICi 23926966. VBITheElo119873_0883.

Phylogenomic databases

eggNOGi COG0854.
HOGENOMi HOG000258094.
KOi K03474.
OMAi VPETRQE.
OrthoDBi EOG6M9F0H.

Enzyme and pathway databases

UniPathwayi UPA00244 ; UER00313 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00279. PdxJ.
InterProi IPR013785. Aldolase_TIM.
IPR004569. PyrdxlP_synth_PdxJ.
[Graphical view ]
Pfami PF03740. PdxJ. 1 hit.
[Graphical view ]
SUPFAMi SSF63892. SSF63892. 1 hit.
TIGRFAMsi TIGR00559. pdxJ. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BP-1.

Entry informationi

Entry nameiPDXJ_THEEB
AccessioniPrimary (citable) accession number: Q8DKM1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: March 1, 2003
Last modified: September 3, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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