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Protein

Pyridoxine 5'-phosphate synthase

Gene

pdxJ

Organism
Thermosynechococcus elongatus (strain BP-1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.UniRule annotation

Catalytic activityi

1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = pyridoxine 5'-phosphate + phosphate + 2 H2O.UniRule annotation

Pathwayi: pyridoxine 5'-phosphate biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes pyridoxine 5'-phosphate from D-erythrose 4-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. 4-hydroxythreonine-4-phosphate dehydrogenase (pdxA)
  5. Pyridoxine 5'-phosphate synthase (pdxJ)
This subpathway is part of the pathway pyridoxine 5'-phosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyridoxine 5'-phosphate from D-erythrose 4-phosphate, the pathway pyridoxine 5'-phosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei73-amino-2-oxopropyl phosphateUniRule annotation1
Binding sitei183-amino-2-oxopropyl phosphateUniRule annotation1
Active sitei43Proton acceptorUniRule annotation1
Binding sitei451-deoxy-D-xylulose 5-phosphateUniRule annotation1
Binding sitei501-deoxy-D-xylulose 5-phosphateUniRule annotation1
Active sitei70Proton acceptorUniRule annotation1
Binding sitei1001-deoxy-D-xylulose 5-phosphateUniRule annotation1
Sitei151Transition state stabilizerUniRule annotation1
Active sitei191Proton donorUniRule annotation1
Binding sitei1923-amino-2-oxopropyl phosphate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processPyridoxine biosynthesis

Enzyme and pathway databases

BioCyciTELO197221:G1G3I-856-MONOMER
UniPathwayiUPA00244; UER00313

Names & Taxonomyi

Protein namesi
Recommended name:
Pyridoxine 5'-phosphate synthaseUniRule annotation (EC:2.6.99.2UniRule annotation)
Short name:
PNP synthaseUniRule annotation
Gene namesi
Name:pdxJUniRule annotation
Ordered Locus Names:tlr0838
OrganismiThermosynechococcus elongatus (strain BP-1)
Taxonomic identifieri197221 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesSynechococcaceaeThermosynechococcus
Proteomesi
  • UP000000440 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001901321 – 238Pyridoxine 5'-phosphate synthaseAdd BLAST238

Interactioni

Subunit structurei

Homooctamer; tetramer of dimers.UniRule annotation

Protein-protein interaction databases

STRINGi197221.tlr0838

Structurei

3D structure databases

ProteinModelPortaliQ8DKM1
SMRiQ8DKM1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni9 – 101-deoxy-D-xylulose 5-phosphate bindingUniRule annotation2
Regioni213 – 2143-amino-2-oxopropyl phosphate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the PNP synthase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CSZ Bacteria
COG0854 LUCA
HOGENOMiHOG000258094
KOiK03474
OMAiTSNAGWD
OrthoDBiPOG091H03D1

Family and domain databases

CDDicd00003 PNPsynthase, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00279 PdxJ, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR004569 PyrdxlP_synth_PdxJ
IPR036130 Pyridoxine-5'_phos_synth
PANTHERiPTHR30456 PTHR30456, 1 hit
PfamiView protein in Pfam
PF03740 PdxJ, 1 hit
SUPFAMiSSF63892 SSF63892, 1 hit
TIGRFAMsiTIGR00559 pdxJ, 1 hit

Sequencei

Sequence statusi: Complete.

Q8DKM1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATLGVNIDH VATIRQARRT VEPDPVAAAL LAELGGADGI TVHLREDRRH
60 70 80 90 100
IQERDVRLLR QTVRTHLNLE MAATPEMVAI ALDIRPDYVT LVPERREEVT
110 120 130 140 150
TEGGLDVVSQ QEPLTQVVQT LQGAGIPVSL FIDADPTQLA AAAKTTAQFI
160 170 180 190 200
ELHTGRYAEA KGEVAQQREL AILADGVQQA KALGLRVNAG HGLTYSNVGA
210 220 230
IARLEGIEEL NIGHTIISRA VLVGMVQAVR DMKALISP
Length:238
Mass (Da):25,658
Last modified:March 1, 2003 - v1
Checksum:i6B5C6061C59D65DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000039 Genomic DNA Translation: BAC08390.1
RefSeqiNP_681628.1, NC_004113.1
WP_011056682.1, NC_004113.1

Genome annotation databases

EnsemblBacteriaiBAC08390; BAC08390; BAC08390
GeneIDi1011556
KEGGitel:tlr0838
PATRICifig|197221.4.peg.883

Similar proteinsi

Entry informationi

Entry nameiPDXJ_THEEB
AccessioniPrimary (citable) accession number: Q8DKM1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: March 1, 2003
Last modified: February 28, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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