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Protein

Ribonuclease Z

Gene

rnz

Organism
Thermosynechococcus elongatus (strain BP-1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity).By similarity

Catalytic activityi

Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi62 – 621Zinc 1; catalyticBy similarity
Metal bindingi64 – 641Zinc 1; catalyticBy similarity
Active sitei66 – 661Proton acceptorSequence analysis
Metal bindingi66 – 661Zinc 2; catalyticBy similarity
Metal bindingi67 – 671Zinc 2; catalyticBy similarity
Metal bindingi139 – 1391Zinc 1; catalyticBy similarity
Metal bindingi210 – 2101Zinc 1; catalyticBy similarity
Metal bindingi210 – 2101Zinc 2; catalyticBy similarity
Metal bindingi268 – 2681Zinc 2; catalyticBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease Z (EC:3.1.26.11)
Short name:
RNase Z
Alternative name(s):
tRNA 3 endonuclease
tRNase Z
Gene namesi
Name:rnz
Ordered Locus Names:tll0915
OrganismiThermosynechococcus elongatus (strain BP-1)
Taxonomic identifieri197221 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesThermosynechococcus
Proteomesi
  • UP000000440 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 407407Ribonuclease ZPRO_0000155914Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi197221.tll0915.

Structurei

3D structure databases

ProteinModelPortaliQ8DKE4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 308308Ribonuclease ZAdd
BLAST
Regioni309 – 40799UnknownAdd
BLAST

Sequence similaritiesi

Belongs to the RNase Z family.Curated

Phylogenomic databases

eggNOGiENOG4105IES. Bacteria.
COG1234. LUCA.
HOGENOMiHOG000272419.
KOiK00784.
OMAiSYAFCSD.
OrthoDBiEOG61P6TK.

Family and domain databases

Gene3Di3.60.15.10. 2 hits.
HAMAPiMF_01818. RNase_Z_BN.
InterProiIPR001279. Metallo-B-lactamas.
IPR013471. RNase_Z/BN.
IPR010994. RuvA_2-like.
[Graphical view]
PfamiPF12706. Lactamase_B_2. 1 hit.
[Graphical view]
SUPFAMiSSF47781. SSF47781. 1 hit.
SSF56281. SSF56281. 1 hit.
TIGRFAMsiTIGR02651. RNase_Z. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8DKE4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEITFLGTSS GVPTRTRNVS SVALRLPQRK EIWLFDCGEA TQHQLLRSDL
60 70 80 90 100
RTSQIRRIFI THMHGDHIFG LMGLLASCGL AGTVSQIDVY GPPTLDRYIA
110 120 130 140 150
SCLRWSVMRL PYKLQVHTVE PGEVFSDGEF TVTCRLLHHR VPAFGYRVTE
160 170 180 190 200
GDRPGRFHVE KAQALGIPFG PLYGQLKQGK TITLEDGRTF DGRDFCDPPQ
210 220 230 240 250
RGRSMVYCTD TVFCDSAVEL AQQADVLIHE ATFSHQEANL AFARLHSTST
260 270 280 290 300
MAAQVAAFAQ VKLLFLTHFS ARYAPGNPVQ VEDLLAEAQA IFPNTRLAQD
310 320 330 340 350
FLHYAIPRDG QICAEMPPSD SPAAANIDTL EATLEPLEAQ TVAADAKNAP
360 370 380 390 400
AIAINRATRQ QMQQKLGIDA TTANAILERR RQQKFTCLGE LERLYPQVDW

SALNVLF
Length:407
Mass (Da):45,213
Last modified:March 1, 2003 - v1
Checksum:iC65FD56BA88A1601
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000039 Genomic DNA. Translation: BAC08467.1.
RefSeqiNP_681705.1. NC_004113.1.
WP_011056759.1. NC_004113.1.

Genome annotation databases

EnsemblBacteriaiBAC08467; BAC08467; BAC08467.
GeneIDi1011409.
KEGGitel:tll0915.
PATRICi23927120. VBITheElo119873_0960.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000039 Genomic DNA. Translation: BAC08467.1.
RefSeqiNP_681705.1. NC_004113.1.
WP_011056759.1. NC_004113.1.

3D structure databases

ProteinModelPortaliQ8DKE4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi197221.tll0915.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC08467; BAC08467; BAC08467.
GeneIDi1011409.
KEGGitel:tll0915.
PATRICi23927120. VBITheElo119873_0960.

Phylogenomic databases

eggNOGiENOG4105IES. Bacteria.
COG1234. LUCA.
HOGENOMiHOG000272419.
KOiK00784.
OMAiSYAFCSD.
OrthoDBiEOG61P6TK.

Family and domain databases

Gene3Di3.60.15.10. 2 hits.
HAMAPiMF_01818. RNase_Z_BN.
InterProiIPR001279. Metallo-B-lactamas.
IPR013471. RNase_Z/BN.
IPR010994. RuvA_2-like.
[Graphical view]
PfamiPF12706. Lactamase_B_2. 1 hit.
[Graphical view]
SUPFAMiSSF47781. SSF47781. 1 hit.
SSF56281. SSF56281. 1 hit.
TIGRFAMsiTIGR02651. RNase_Z. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BP-1.

Entry informationi

Entry nameiRNZ_THEEB
AccessioniPrimary (citable) accession number: Q8DKE4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: March 1, 2003
Last modified: May 11, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.