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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Thermosynechococcus elongatus (strain BP-1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:tll0971
OrganismiThermosynechococcus elongatus (strain BP-1)
Taxonomic identifieri197221 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesSynechococcaceaeThermosynechococcus
Proteomesi
  • UP000000440 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei26 – 46HelicalUniRule annotationAdd BLAST21
Transmembranei57 – 77HelicalUniRule annotationAdd BLAST21
Transmembranei103 – 123HelicalUniRule annotationAdd BLAST21
Transmembranei127 – 147HelicalUniRule annotationAdd BLAST21
Transmembranei171 – 191HelicalUniRule annotationAdd BLAST21
Transmembranei195 – 215HelicalUniRule annotationAdd BLAST21
Transmembranei225 – 245HelicalUniRule annotationAdd BLAST21
Transmembranei247 – 267HelicalUniRule annotationAdd BLAST21
Transmembranei275 – 295HelicalUniRule annotationAdd BLAST21
Transmembranei302 – 322HelicalUniRule annotationAdd BLAST21
Transmembranei356 – 376HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001089131 – 378Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST378

Interactioni

Protein-protein interaction databases

STRINGi197221.tll0971.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CPY. Bacteria.
COG0472. LUCA.
HOGENOMiHOG000275124.
KOiK01000.
OMAiLMSPLHH.
OrthoDBiPOG091H00VH.

Family and domain databases

CDDicd06852. GT_MraY. 1 hit.
HAMAPiMF_00038. MraY. 1 hit.
InterProiView protein in InterPro
IPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
PANTHERiPTHR22926. PTHR22926. 1 hit.
PfamiView protein in Pfam
PF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
TIGRFAMsiTIGR00445. mraY. 1 hit.
PROSITEiView protein in PROSITE
PS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8DK95-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLERPPMPST KTTAAIEPRW RAGQRLFRLL AIGLLIVTIA YDTGANHWQQ
60 70 80 90 100
PLQTLTLPWL VSFALVAVLG MAVVPLLRRL KTGQIIREDG PQSHLQKSGT
110 120 130 140 150
PTMGGIFFVP TGLGLAFLWT GFAQGKLSPT VGAIALLVLW YAAIGWWDDW
160 170 180 190 200
QVLRRQSNKG LSARLRLLLE GIGAALFCAW LVASDPTATV VTAPWGWVWP
210 220 230 240 250
LGMAFIPLAI FVPMAEGNAL NLTDGLDGLA GGTGAIALLT LGIILSPYPD
260 270 280 290 300
LQILAVVMSG ACLGFLWHNH HPARVFMGDT GSLALGAVLA GIGLASHHLW
310 320 330 340 350
ELLIVSGLFF VESLSVIAQV LYYKATKGPD GVGKRLLRMA PLHHHFELGG
360 370
WSELRIVRTF YGVVALLGLL CVLLQWLA
Length:378
Mass (Da):40,863
Last modified:March 1, 2003 - v1
Checksum:iAB9809D1B77B3178
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000039 Genomic DNA. Translation: BAC08523.1.
RefSeqiNP_681761.1. NC_004113.1.
WP_011056815.1. NC_004113.1.

Genome annotation databases

EnsemblBacteriaiBAC08523; BAC08523; BAC08523.
GeneIDi1011350.
KEGGitel:tll0971.
PATRICifig|197221.4.peg.1019.

Similar proteinsi

Entry informationi

Entry nameiMRAY_THEEB
AccessioniPrimary (citable) accession number: Q8DK95
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 1, 2003
Last modified: June 7, 2017
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families