Q8DJW4 (OTC_THEEB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ornithine carbamoyltransferase
Short name=OTCase
EC=2.1.3.3

Gene names

Name:	argF
Ordered Locus Names:	tll1106

Organism

Thermosynechococcus elongatus (strain BP-1)

Taxonomic identifier

197221 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Thermosynechococcus

Protein attributes

Sequence length	310 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. HAMAP MF_01109
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 1/3. HAMAP MF_01109
Subcellular location	Cytoplasm Probable HAMAP MF_01109.
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	ornithine carbamoyltransferase complex Inferred from electronic annotation. Source: InterPro
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro ornithine carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 310	310	Ornithine carbamoyltransferase HAMAP MF_01109		PRO_0000113045
Regions
	Region	57 – 61	5	Carbamoyl phosphate binding By similarity
	Region	268 – 271	4	Ornithine binding By similarity
Sites
	Binding site	108	1	Carbamoyl phosphate By similarity
	Binding site	135	1	Carbamoyl phosphate By similarity
	Site	37	1	Important for structural integrity By similarity
	Site	148	1	Important for structural integrity By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8DJW4 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: ACF3463DB230D166	FASTA	310	33,553
	10 20 30 40 50 60 MVGRFVMETL RGRDLLSIAD LSRAEAEYLL DLAAQMKIGK VAPQCPKVLG LLFQKASTRT 70 80 90 100 110 120 RVSFTVAMYQ LGGQVIDLNP QSTQVGRGEP LTDTARVLDR YLDAVAIRTY GQAELQLFAD 130 140 150 160 170 180 YARIPVINAL TDREHPCQIL ADLLTLRESF GTLAGLTLCY IGDGNNVAHS LLLGCALLGV 190 200 210 220 230 240 NIRVASPPQF APLADIVAQA KALSGGKSEV AVLTDPQAAA KGAHALYTDV WASMGQEAEA 250 260 270 280 290 300 GDRQPIFQPY QINDHLLALA DPRAIVLHCL PAHRDEEITA SVLEGPQSRV WEQAENRLHV 310 QKALLASLLV

References

[1]

"Complete genome structure of the thermophilic cyanobacterium Thermosynechococcus elongatus BP-1." Nakamura Y., Kaneko T., Sato S., Ikeuchi M., Katoh H., Sasamoto S., Watanabe A., Iriguchi M., Kawashima K., Kimura T., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Nakazaki N., Shimpo S., Sugimoto M. , Takeuchi C., Yamada M., Tabata S. DNA Res. 9:123-130(2002) [PubMed: 12240834] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: BP-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000039 Genomic DNA. Translation: BAC08659.1.
RefSeq	NP_681897.1. NC_004113.1.
3D structure databases
ProteinModelPortal	Q8DJW4.
SMR	Q8DJW4. Positions 12-309.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8DJW4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1012256.
GenomeReviews	Gene locus tll1106 in contig BA000039_GR.
KEGG	tel:tll1106.
NMPDR	fig|197221.1.peg.1106.
PATRIC	23927524. VBITheElo119873_1160.
Phylogenomic databases
eggNOG	COG0078.
HOGENOM	HBG579429.
OMA	KHLLSIK.
ProtClustDB	PRK00779.
Enzyme and pathway databases
BioCyc	TELO197221:TLL1106-MONOMER.
Family and domain databases
HAMAP	MF_01109. OTCase. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002292. Orn/put_carbamltrans. IPR024904. Orn_carbamltrans. [Graphical view]
KO	K00611.
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00102. OTCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00658. Orni_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OTC_THEEB

Accession

Primary (citable) accession number: Q8DJW4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2003
Last sequence update:	March 1, 2003
Last modified:	January 25, 2012
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program