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Q8DJI6

- GLMS_THEEB

UniProt

Q8DJI6 - GLMS_THEEB

Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Thermosynechococcus elongatus (strain BP-1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

    Catalytic activityi

    L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
    Active sitei621 – 6211For Fru-6P isomerization activityUniRule annotation

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. carbohydrate biosynthetic process Source: InterPro
    2. glutamine metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Protein family/group databases

    MEROPSiC44.971.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
    Alternative name(s):
    D-fructose-6-phosphate amidotransferaseUniRule annotation
    GFATUniRule annotation
    Glucosamine-6-phosphate synthaseUniRule annotation
    Hexosephosphate aminotransferaseUniRule annotation
    L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
    Gene namesi
    Name:glmSUniRule annotation
    Ordered Locus Names:tll1237
    OrganismiThermosynechococcus elongatus (strain BP-1)
    Taxonomic identifieri197221 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesThermosynechococcus
    ProteomesiUP000000440: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedUniRule annotation
    Chaini2 – 626625Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135398Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi197221.tll1237.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8DJI6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 222221Glutamine amidotransferase type-2UniRule annotationAdd
    BLAST
    Domaini293 – 441149SIS 1UniRule annotationAdd
    BLAST
    Domaini471 – 616146SIS 2UniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
    Contains 2 SIS domains.UniRule annotation

    Keywords - Domaini

    Glutamine amidotransferase, Repeat

    Phylogenomic databases

    eggNOGiCOG0449.
    HOGENOMiHOG000258896.
    KOiK00820.
    OMAiPVTRRFM.
    OrthoDBiEOG6KT2Q1.

    Family and domain databases

    Gene3Di3.60.20.10. 1 hit.
    HAMAPiMF_00164. GlmS.
    InterProiIPR017932. GATase_2_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view]
    PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
    PfamiPF01380. SIS. 2 hits.
    [Graphical view]
    SUPFAMiSSF56235. SSF56235. 1 hit.
    TIGRFAMsiTIGR01135. glmS. 1 hit.
    PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8DJI6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCGIVGYIGP QGAAQILLQG LQKLEYRGYD SAGIATLNEG ELLCVRAKGK    50
    LQNLVEKVEQ LDIVAHVGIG HTRWATHGKP EEYNAHPHRD SRDRLAVVQN 100
    GIIENYRELR DQLQARGHIF RSETDTEVIP HLIAELLPET PTANGLLEAV 150
    RQAVHQLEGA FAIAVICADY PDELIVARQQ APLVIGFGQG EFFCASDTPA 200
    IIPYTRAVLP LENGELARLT PTGVEVYDFE GHRLRKTPRT LNWNPVMVEK 250
    QGFKHYMLKE IYEQPGVVRA CLENYLRADW EVASPFSPVQ LNLPPSLLDN 300
    LQHIQIVACG TSWHAGLVGK YLLEQVAQIP TSVQYASEFR YAPPPLLPHT 350
    LTIGVTQSGE TADTLAALEM ELKRRQGLDG ALQPRLLGIT NRPESSLGHL 400
    VPHIIDTRAG IEIGVAATKT FVAQLMAFYL LTLELSWQRQ SCDRSRLAEL 450
    VTGLRQLPAQ MEQILESQER YIEALSHDFW ETQDFIFLGR GINFPIALEG 500
    ALKLKEISYI HAEGYPAGEM KHGPIALLDA KVPVVTIAMP GSVFEKVLSN 550
    AQEARARDAR LIGVTPLDEA EAQHTFDNLL PVPEVDELLS PILTVIPLQL 600
    LAYHIAARRG LDVDQPRNLA KSVTVE 626
    Length:626
    Mass (Da):69,351
    Last modified:January 23, 2007 - v3
    Checksum:i7F08A571AFBEAFD2
    GO

    Sequence cautioni

    The sequence BAC08789.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000039 Genomic DNA. Translation: BAC08789.1. Different initiation.
    RefSeqiNP_682027.1. NC_004113.1.

    Genome annotation databases

    EnsemblBacteriaiBAC08789; BAC08789; BAC08789.
    GeneIDi1010480.
    KEGGitel:tll1237.
    PATRICi23927806. VBITheElo119873_1301.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000039 Genomic DNA. Translation: BAC08789.1 . Different initiation.
    RefSeqi NP_682027.1. NC_004113.1.

    3D structure databases

    ProteinModelPortali Q8DJI6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 197221.tll1237.

    Protein family/group databases

    MEROPSi C44.971.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC08789 ; BAC08789 ; BAC08789 .
    GeneIDi 1010480.
    KEGGi tel:tll1237.
    PATRICi 23927806. VBITheElo119873_1301.

    Phylogenomic databases

    eggNOGi COG0449.
    HOGENOMi HOG000258896.
    KOi K00820.
    OMAi PVTRRFM.
    OrthoDBi EOG6KT2Q1.

    Family and domain databases

    Gene3Di 3.60.20.10. 1 hit.
    HAMAPi MF_00164. GlmS.
    InterProi IPR017932. GATase_2_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view ]
    PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
    Pfami PF01380. SIS. 2 hits.
    [Graphical view ]
    SUPFAMi SSF56235. SSF56235. 1 hit.
    TIGRFAMsi TIGR01135. glmS. 1 hit.
    PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BP-1.

    Entry informationi

    Entry nameiGLMS_THEEB
    AccessioniPrimary (citable) accession number: Q8DJI6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 16, 2003
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 75 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3