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Q8DJE4

- MTAP_THEEB

UniProt

Q8DJE4 - MTAP_THEEB

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Protein

S-methyl-5'-thioadenosine phosphorylase

Gene

mtnP

Organism
Thermosynechococcus elongatus (strain BP-1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.UniRule annotation

Catalytic activityi

S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei11 – 111PhosphateUniRule annotation
Sitei169 – 1691Important for substrate specificityUniRule annotation
Binding sitei187 – 1871Substrate; via amide nitrogenUniRule annotation
Binding sitei188 – 1881PhosphateUniRule annotation
Sitei224 – 2241Important for substrate specificityUniRule annotation

GO - Molecular functioni

  1. phosphorylase activity Source: InterPro
  2. S-methyl-5-thioadenosine phosphorylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. L-methionine biosynthetic process from methylthioadenosine Source: UniProtKB-HAMAP
  2. purine ribonucleoside salvage Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Purine salvage

Enzyme and pathway databases

UniPathwayiUPA00904; UER00873.

Names & Taxonomyi

Protein namesi
Recommended name:
S-methyl-5'-thioadenosine phosphorylaseUniRule annotation (EC:2.4.2.28UniRule annotation)
Alternative name(s):
5'-methylthioadenosine phosphorylaseUniRule annotation
Short name:
MTA phosphorylaseUniRule annotation
Short name:
MTAPUniRule annotation
Gene namesi
Name:mtnPUniRule annotation
Ordered Locus Names:tlr1281
OrganismiThermosynechococcus elongatus (strain BP-1)
Taxonomic identifieri197221 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesThermosynechococcus
ProteomesiUP000000440: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 289289S-methyl-5'-thioadenosine phosphorylasePRO_0000415101Add
BLAST

Interactioni

Subunit structurei

Homohexamer. Dimer of a homotrimer.UniRule annotation

Protein-protein interaction databases

STRINGi197221.tlr1281.

Structurei

3D structure databases

ProteinModelPortaliQ8DJE4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni53 – 542Phosphate bindingUniRule annotation
Regioni86 – 872Phosphate bindingUniRule annotation
Regioni211 – 2133Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0005.
HOGENOMiHOG000228986.
KOiK00772.
OMAiCEAQLCY.
OrthoDBiEOG6KHFXC.

Family and domain databases

Gene3Di3.40.50.1580. 1 hit.
HAMAPiMF_01963. MTAP.
InterProiIPR010044. MTAP.
IPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
[Graphical view]
PANTHERiPTHR11904. PTHR11904. 1 hit.
PfamiPF01048. PNP_UDP_1. 1 hit.
[Graphical view]
SUPFAMiSSF53167. SSF53167. 1 hit.
TIGRFAMsiTIGR01694. MTAP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8DJE4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTAKIGIIGG SGLYKMEALT DVEEVRLTTP FGDPSDAFIC GKIGGVPVVF
60 70 80 90 100
LARHGRHHHL LPTEIPFRAN IYGFKSLGVE YLLSASAVGS LQEAVKPLDI
110 120 130 140 150
VVPDQFIDRT RNRISTFFGD GIVAHIGFAD PVCPALAGVL ADAIADLNLP
160 170 180 190 200
DVTLHRQGTY VCMEGPAFST LAESNLYRSW GGTVIGMTNL PEAKLAREAE
210 220 230 240 250
IAYATLALVT DYDCWHPEHD SVTVEMIMGN LQRNVKNAQA IICETVKRVH
260 270 280
AHPPVSKAHR ALKNAILTPL DQVPAATKEK LHLLLAKYL
Length:289
Mass (Da):31,354
Last modified:March 1, 2003 - v1
Checksum:iE78D1687C7C49704
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000039 Genomic DNA. Translation: BAC08833.1.
RefSeqiNP_682071.1. NC_004113.1.
WP_011057121.1. NC_004113.1.

Genome annotation databases

EnsemblBacteriaiBAC08833; BAC08833; BAC08833.
GeneIDi1011666.
KEGGitel:tlr1281.
PATRICi23927900. VBITheElo119873_1348.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000039 Genomic DNA. Translation: BAC08833.1 .
RefSeqi NP_682071.1. NC_004113.1.
WP_011057121.1. NC_004113.1.

3D structure databases

ProteinModelPortali Q8DJE4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 197221.tlr1281.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC08833 ; BAC08833 ; BAC08833 .
GeneIDi 1011666.
KEGGi tel:tlr1281.
PATRICi 23927900. VBITheElo119873_1348.

Phylogenomic databases

eggNOGi COG0005.
HOGENOMi HOG000228986.
KOi K00772.
OMAi CEAQLCY.
OrthoDBi EOG6KHFXC.

Enzyme and pathway databases

UniPathwayi UPA00904 ; UER00873 .

Family and domain databases

Gene3Di 3.40.50.1580. 1 hit.
HAMAPi MF_01963. MTAP.
InterProi IPR010044. MTAP.
IPR000845. Nucleoside_phosphorylase_d.
IPR001369. PNP/MTAP.
[Graphical view ]
PANTHERi PTHR11904. PTHR11904. 1 hit.
Pfami PF01048. PNP_UDP_1. 1 hit.
[Graphical view ]
SUPFAMi SSF53167. SSF53167. 1 hit.
TIGRFAMsi TIGR01694. MTAP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BP-1.

Entry informationi

Entry nameiMTAP_THEEB
AccessioniPrimary (citable) accession number: Q8DJE4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3