Reviewed, UniProtKB/Swiss-Prot Q8DJ05 (ACSF1_THEEB)

Names and origin

Protein names

Recommended name:
    Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase 1
      Short name=Mg-protoporphyrin IX monomethyl ester oxidative cyclase 1
    EC=1.14.13.81

Gene names

Name:	acsF1
Ordered Locus Names:	tlr1426

Organism

Thermosynechococcus elongatus (strain BP-1) [Complete proteome] [HAMAP]

Taxonomic identifier

197221 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Thermosynechococcus

Protein attributes

Sequence length	380 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) By similarity. HAMAP MF_01840
Catalytic activity	Magnesium-protoporphyrin IX 13-monomethyl ester + NADPH + O2 = 131-hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester + NADP+ + H2O. HAMAP MF_01840 131-hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester + NADPH + O2 = 131-oxo-magnesium-protoporphyrin IX 13-monomethyl ester + NADP+ + 2 H2O. HAMAP MF_01840 131-oxo-magnesium-protoporphyrin IX 13-monomethyl ester + NADPH + O2 = divinylprotochlorophyllide + NADP+ + 2 H2O. HAMAP MF_01840
Cofactor	Iron By similarity. HAMAP MF_01840
Pathway	Porphyrin biosynthesis; chlorophyll biosynthesis (light-independent). HAMAP MF_01840
Sequence similarities	Belongs to the acsF family.

Ontologies

Keywords
Biological process	Chlorophyll biosynthesis Photosynthesis
Ligand	Iron Metal-binding NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	chlorophyll biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW photosynthesis Inferred from electronic annotation. Source: HAMAP
Molecular function	iron ion binding Inferred from electronic annotation. Source: HAMAP magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 380	380	Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase 1 HAMAP MF_01840		PRO_0000217535

Sequences

	Sequence		Length	Mass (Da)
	Q8DJ05-1 [UniParc]. Last modified August 16, 2005. Version 2. Checksum: 86C8DC83BBDFAF73	FASTA	380	45,481
	10 20 30 40 50 60 MVNTVAKPEF EELRPGIKAP AKETILTPRF YTTDFEAMAN MDITENKAEL EAILEEFRCD 70 80 90 100 110 120 YNRHHFVRDE EFEQSWDHID GETRRLFIEF LERSCTAEFS GFLLYKELSR RLKDRNPLLA 130 140 150 160 170 180 ECFALMSRDE ARHAGFLNKA MADFNLSLDL GFLTQHRSYT YFEPEFIFYA TYLSEKIGYW 190 200 210 220 230 240 RYITIYRHLE KHPEHRIYPI FRFFENWCQD ENRHGDFFDA VMRAQPQMLD RPRTFWQKIK 250 260 270 280 290 300 EIPLSLSGKK WARYFMVCWV PPKLWCRFFL LSVFATMYLN DLQRAKFYTA LGLDAREYDR 310 320 330 340 350 360 EVIAKTNETA GRVFPVILDV DHPEFYQRLE RCVENNAKLT EIAKQNGGFL KKLPLYLSNV 370 380 WQMIKLFLIP AKEPTRVAVR

References

[1]

"Complete genome structure of the thermophilic cyanobacterium Thermosynechococcus elongatus BP-1." Nakamura Y., Kaneko T., Sato S., Ikeuchi M., Katoh H., Sasamoto S., Watanabe A., Iriguchi M., Kawashima K., Kimura T., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Nakazaki N., Shimpo S., Sugimoto M. , Takeuchi C., Yamada M., Tabata S. DNA Res. 9:123-130(2002) [PubMed: 12240834] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000039 Genomic DNA. Translation: BAC08978.1. Different initiation.
RefSeq	NP_682216.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q8DJ05.
Genome annotation databases
GeneID	1011675.
GenomeReviews	Gene locus tlr1426 in contig BA000039_GR.
KEGG	tel:tlr1426.
NMPDR	fig|197221.1.peg.1425.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	NOG10633.
HOGENOM	HBG284843.
OMA	YARYITI.
Enzyme and pathway databases
BioCyc	TELO197221:TLR1426-MONOMER.
BRENDA	1.14.13.81. 277225.
Family and domain databases
HAMAP	MF_01840. AcsF. [Tree]
InterPro	IPR008434. AcsF. IPR009078. Ferritin/RR-like. IPR003251. Rubrerythrin. [Graphical view]
Pfam	PF02915. Rubrerythrin. 1 hit. [Graphical view]
TIGRFAMs	TIGR02029. AcsF. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ACSF1_THEEB

Accession

Primary (citable) accession number: Q8DJ05

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2005
Last sequence update:	August 16, 2005
Last modified:	February 9, 2010
This is version 47 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)