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Q8DJ05 (ACSF1_THEEB) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase 1

Short name=Mg-protoporphyrin IX monomethyl ester oxidative cyclase 1
EC=1.14.13.81
Gene names
Name:acsF1
Ordered Locus Names:tlr1426
OrganismThermosynechococcus elongatus (strain BP-1) [Reference proteome] [HAMAP]
Taxonomic identifier197221 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesThermosynechococcus

Protein attributes

Sequence length380 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) By similarity. HAMAP-Rule MF_01840

Catalytic activity

Magnesium-protoporphyrin IX 13-monomethyl ester + 3 NADPH + 3 O2 = divinylprotochlorophyllide + 3 NADP+ + 5 H2O. HAMAP-Rule MF_01840

Cofactor

Iron By similarity. HAMAP-Rule MF_01840

Pathway

Porphyrin-containing compound metabolism; chlorophyll biosynthesis (light-independent). HAMAP-Rule MF_01840

Sequence similarities

Belongs to the AcsF family.

Sequence caution

The sequence BAC08978.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 380380Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase 1 HAMAP-Rule MF_01840
PRO_0000217535

Sequences

Sequence LengthMass (Da)Tools
Q8DJ05 [UniParc].

Last modified August 16, 2005. Version 2.
Checksum: 86C8DC83BBDFAF73

FASTA38045,481
        10         20         30         40         50         60 
MVNTVAKPEF EELRPGIKAP AKETILTPRF YTTDFEAMAN MDITENKAEL EAILEEFRCD 

        70         80         90        100        110        120 
YNRHHFVRDE EFEQSWDHID GETRRLFIEF LERSCTAEFS GFLLYKELSR RLKDRNPLLA 

       130        140        150        160        170        180 
ECFALMSRDE ARHAGFLNKA MADFNLSLDL GFLTQHRSYT YFEPEFIFYA TYLSEKIGYW 

       190        200        210        220        230        240 
RYITIYRHLE KHPEHRIYPI FRFFENWCQD ENRHGDFFDA VMRAQPQMLD RPRTFWQKIK 

       250        260        270        280        290        300 
EIPLSLSGKK WARYFMVCWV PPKLWCRFFL LSVFATMYLN DLQRAKFYTA LGLDAREYDR 

       310        320        330        340        350        360 
EVIAKTNETA GRVFPVILDV DHPEFYQRLE RCVENNAKLT EIAKQNGGFL KKLPLYLSNV 

       370        380 
WQMIKLFLIP AKEPTRVAVR 

« Hide

References

[1]"Complete genome structure of the thermophilic cyanobacterium Thermosynechococcus elongatus BP-1."
Nakamura Y., Kaneko T., Sato S., Ikeuchi M., Katoh H., Sasamoto S., Watanabe A., Iriguchi M., Kawashima K., Kimura T., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Nakazaki N., Shimpo S., Sugimoto M. expand/collapse author list , Takeuchi C., Yamada M., Tabata S.
DNA Res. 9:123-130(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: BP-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000039 Genomic DNA. Translation: BAC08978.1. Different initiation.
RefSeqNP_682216.1. NC_004113.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING197221.tlr1426.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAC08978; BAC08978; BAC08978.
GeneID1011675.
KEGGtel:tlr1426.
PATRIC23928204. VBITheElo119873_1498.

Phylogenomic databases

eggNOGNOG10633.
HOGENOMHOG000233491.
KOK04035.
OMANPLLAEC.
OrthoDBEOG6GJBQ8.

Enzyme and pathway databases

UniPathwayUPA00670.

Family and domain databases

HAMAPMF_01840. AcsF.
InterProIPR008434. AcsF.
IPR009078. Ferritin-like_SF.
IPR003251. Rubrerythrin.
[Graphical view]
PfamPF02915. Rubrerythrin. 1 hit.
[Graphical view]
SUPFAMSSF47240. SSF47240. 1 hit.
TIGRFAMsTIGR02029. AcsF. 1 hit.
ProtoNetSearch...

Entry information

Entry nameACSF1_THEEB
AccessionPrimary (citable) accession number: Q8DJ05
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: August 16, 2005
Last modified: May 14, 2014
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways