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Protein

Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase 1

Gene

acsF1

Organism
Thermosynechococcus elongatus (strain BP-1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME).UniRule annotation

Catalytic activityi

Magnesium-protoporphyrin IX 13-monomethyl ester + 3 NADPH + 3 O2 = divinylprotochlorophyllide + 3 NADP+ + 5 H2O.UniRule annotation

Cofactori

Fe cationUniRule annotation

Pathwayi

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Chlorophyll biosynthesis, Photosynthesis

Keywords - Ligandi

Iron, Metal-binding, NADP

Enzyme and pathway databases

UniPathwayiUPA00670.

Names & Taxonomyi

Protein namesi
Recommended name:
Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase 1UniRule annotation (EC:1.14.13.81UniRule annotation)
Short name:
Mg-protoporphyrin IX monomethyl ester oxidative cyclase 1UniRule annotation
Gene namesi
Name:acsF1UniRule annotation
Ordered Locus Names:tlr1426
OrganismiThermosynechococcus elongatus (strain BP-1)
Taxonomic identifieri197221 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesThermosynechococcus
ProteomesiUP000000440 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 380380Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase 1PRO_0000217535Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi197221.tlr1426.

Family & Domainsi

Sequence similaritiesi

Belongs to the AcsF family.UniRule annotation

Phylogenomic databases

eggNOGiNOG10633.
HOGENOMiHOG000233491.
KOiK04035.
OMAiFHPIFKW.
OrthoDBiEOG6GJBQ8.

Family and domain databases

HAMAPiMF_01840. AcsF.
InterProiIPR008434. AcsF.
IPR009078. Ferritin-like_SF.
IPR003251. Rubrerythrin.
[Graphical view]
PfamiPF02915. Rubrerythrin. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
TIGRFAMsiTIGR02029. AcsF. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8DJ05-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVNTVAKPEF EELRPGIKAP AKETILTPRF YTTDFEAMAN MDITENKAEL
60 70 80 90 100
EAILEEFRCD YNRHHFVRDE EFEQSWDHID GETRRLFIEF LERSCTAEFS
110 120 130 140 150
GFLLYKELSR RLKDRNPLLA ECFALMSRDE ARHAGFLNKA MADFNLSLDL
160 170 180 190 200
GFLTQHRSYT YFEPEFIFYA TYLSEKIGYW RYITIYRHLE KHPEHRIYPI
210 220 230 240 250
FRFFENWCQD ENRHGDFFDA VMRAQPQMLD RPRTFWQKIK EIPLSLSGKK
260 270 280 290 300
WARYFMVCWV PPKLWCRFFL LSVFATMYLN DLQRAKFYTA LGLDAREYDR
310 320 330 340 350
EVIAKTNETA GRVFPVILDV DHPEFYQRLE RCVENNAKLT EIAKQNGGFL
360 370 380
KKLPLYLSNV WQMIKLFLIP AKEPTRVAVR
Length:380
Mass (Da):45,481
Last modified:August 16, 2005 - v2
Checksum:i86C8DC83BBDFAF73
GO

Sequence cautioni

The sequence BAC08978.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000039 Genomic DNA. Translation: BAC08978.1. Different initiation.
RefSeqiNP_682216.1. NC_004113.1.

Genome annotation databases

EnsemblBacteriaiBAC08978; BAC08978; BAC08978.
GeneIDi1011675.
KEGGitel:tlr1426.
PATRICi23928204. VBITheElo119873_1498.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000039 Genomic DNA. Translation: BAC08978.1. Different initiation.
RefSeqiNP_682216.1. NC_004113.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi197221.tlr1426.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAC08978; BAC08978; BAC08978.
GeneIDi1011675.
KEGGitel:tlr1426.
PATRICi23928204. VBITheElo119873_1498.

Phylogenomic databases

eggNOGiNOG10633.
HOGENOMiHOG000233491.
KOiK04035.
OMAiFHPIFKW.
OrthoDBiEOG6GJBQ8.

Enzyme and pathway databases

UniPathwayiUPA00670.

Family and domain databases

HAMAPiMF_01840. AcsF.
InterProiIPR008434. AcsF.
IPR009078. Ferritin-like_SF.
IPR003251. Rubrerythrin.
[Graphical view]
PfamiPF02915. Rubrerythrin. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
TIGRFAMsiTIGR02029. AcsF. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BP-1.

Entry informationi

Entry nameiACSF1_THEEB
AccessioniPrimary (citable) accession number: Q8DJ05
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: August 16, 2005
Last modified: January 7, 2015
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.