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Q8DIN5

- PUR9_THEEB

UniProt

Q8DIN5 - PUR9_THEEB

Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Thermosynechococcus elongatus (strain BP-1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
    IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
    2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase, Transferase

    Keywords - Biological processi

    Purine biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00074; UER00133.
    UPA00074; UER00135.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional purine biosynthesis protein PurHUniRule annotation
    Including the following 2 domains:
    Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
    Alternative name(s):
    AICAR transformylaseUniRule annotation
    IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
    Alternative name(s):
    ATICUniRule annotation
    IMP synthaseUniRule annotation
    InosinicaseUniRule annotation
    Gene namesi
    Name:purHUniRule annotation
    Ordered Locus Names:tlr1547
    OrganismiThermosynechococcus elongatus (strain BP-1)
    Taxonomic identifieri197221 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesThermosynechococcus
    ProteomesiUP000000440: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 518518Bifunctional purine biosynthesis protein PurHPRO_0000192140Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi197221.tlr1547.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8DIN5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

    Sequence similaritiesi

    Belongs to the PurH family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0138.
    HOGENOMiHOG000230373.
    KOiK00602.
    OMAiCGVATGP.
    OrthoDBiEOG6QCDFF.

    Family and domain databases

    Gene3Di3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPiMF_00139. PurH.
    InterProiIPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view]
    PANTHERiPTHR11692. PTHR11692. 1 hit.
    PfamiPF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsiTIGR00355. purH. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8DIN5-1 [UniParc]FASTAAdd to Basket

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    MGRMALLSTS NKQGLVELAR ALVQEFGFTL LSSGGTAKAL QTAGIPVTTV    50
    SEYTGAPEIL GGRVKTLHPK IHGGILARRD RPQDEADLQA QAIHPIDLVV 100
    VNLYPFAETI AQPNVTLAEA IEQIDIGGPT LIRAAAKNHA HVTVLVDPSQ 150
    YETYLQELRL YGDAQPAFRL ACAQQAFALT AHYDQAIAEY LQKVTAAGTE 200
    PEILPPVFHL TGRQKQVLRY GENPHQRASW YVCGAHPRGW AAAHLLQGKE 250
    LSYNNLLDLE AARGVISEFL GDSPPAAVII KHTNPCGVAE GKTLVEAYER 300
    AFAADRVSAF GGIVALNRPL DGATAEALTR TFLECVVAPA CEEAALPILK 350
    TKPKMRVLTL PELHRAPTTA IQTIAGGFLV QEIHPLPIDP EAWQVVTATE 400
    PSPELMAELI FAWKVVKHVK SNAIVVSRDR QTQGIGAGQM NRVGAVEIAL 450
    SAAGEAARGG VLASDGFFPF ADSVEAAALA GIAAIIQPGG SLRDSESIQA 500
    ANAAGIAMVF TNQRHFRH 518
    Length:518
    Mass (Da):55,271
    Last modified:March 1, 2003 - v1
    Checksum:iF1010485BADCEFB6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000039 Genomic DNA. Translation: BAC09099.1.
    RefSeqiNP_682337.1. NC_004113.1.

    Genome annotation databases

    EnsemblBacteriaiBAC09099; BAC09099; BAC09099.
    GeneIDi1011044.
    KEGGitel:tlr1547.
    PATRICi23928458. VBITheElo119873_1623.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000039 Genomic DNA. Translation: BAC09099.1 .
    RefSeqi NP_682337.1. NC_004113.1.

    3D structure databases

    ProteinModelPortali Q8DIN5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 197221.tlr1547.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC09099 ; BAC09099 ; BAC09099 .
    GeneIDi 1011044.
    KEGGi tel:tlr1547.
    PATRICi 23928458. VBITheElo119873_1623.

    Phylogenomic databases

    eggNOGi COG0138.
    HOGENOMi HOG000230373.
    KOi K00602.
    OMAi CGVATGP.
    OrthoDBi EOG6QCDFF.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00133 .
    UPA00074 ; UER00135 .

    Family and domain databases

    Gene3Di 3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPi MF_00139. PurH.
    InterProi IPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view ]
    PANTHERi PTHR11692. PTHR11692. 1 hit.
    Pfami PF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsi TIGR00355. purH. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BP-1.

    Entry informationi

    Entry nameiPUR9_THEEB
    AccessioniPrimary (citable) accession number: Q8DIN5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3