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Q8DII3

- GCSP_THEEB

UniProt

Q8DII3 - GCSP_THEEB

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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Thermosynechococcus elongatus (strain BP-1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:tll1603
OrganismiThermosynechococcus elongatus (strain BP-1)
Taxonomic identifieri197221 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesThermosynechococcus
ProteomesiUP000000440: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 954954Glycine dehydrogenase (decarboxylating)PRO_0000166940Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei706 – 7061N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi197221.tll1603.

Structurei

3D structure databases

ProteinModelPortaliQ8DII3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8DII3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMVSSPPQLE INLETDAEFV ARHIGITPSD LPKMLSLLGY GSLKELINAV
60 70 80 90 100
IPPEIRLQRP LALSEGLSET AALQKLRTLA QQNQVWRSYI GMGYYNCITP
110 120 130 140 150
SVIQRNILEN PGWYTQYTPY QAEIAQGRLE ALLNFQTLVS DLTGLAIANA
160 170 180 190 200
SLLDEATAAA EAMTLSFNAC RQRGANRFLV AQDCHPQTLA VLRTRALPLG
210 220 230 240 250
IQIVPIDPIA GELPWENAFG LLLQYPASDG AVRSPQALIA AAHERGLLVT
260 270 280 290 300
VATDLLALTL LRPPGELGAD IAVGSSQRFG VPLGYGGPHA AFFATREDFK
310 320 330 340 350
RQLPGRLVGV SHDALGQRAL RLALQTREQH IRREKATSNI CTAQVLLAVV
360 370 380 390 400
ASMYAVYHGP DGLRQIAERI HQRTVRLAAG LEAAGYQLYY SEFFDTLRIG
410 420 430 440 450
LGNLPVPVLK ERAAAARINL RYFDDGSAGI SLDETTTEKD VADLLALFGA
460 470 480 490 500
RPAEVEGGDR LPAALKRQSP YLQHPVFQDY HSEHALLRYI HRLQAKDLSL
510 520 530 540 550
TTSMIPLGSC TMKLNATAEM LPISWPEFNQ LHPFAPQEQA QGYQALFREL
560 570 580 590 600
AAMLAEITGF DAISLQPNAG SQGEYAGLLV IRQYHHSRGE SQRNVCLIPT
610 620 630 640 650
SAHGTNPASA VMAGMQVVAV NCDAQGNIDV ADLAAKAETY GDRLAALMIT
660 670 680 690 700
YPSTHGVFET GICQICDIIH RYGGQVYMDG ANMNAQVGLC RPGDFGADVC
710 720 730 740 750
HLNLHKTFCI PHGGGGPGVG PIGVKAHLAP FLPTTQVIPQ GSETGPVTAA
760 770 780 790 800
PWGSASILPI SWMYITLMGG VGLTRATAIA ILNANYIAKR LEPYYPVLYK
810 820 830 840 850
GAHGLVAHEC ILDLRPLKKS AGIEVEDIAK RLMDYGFHAP TVSWPVPGTL
860 870 880 890 900
MIEPTESETK AELDRFCEAM IAIRSEIAEI EAGVSDRQQN PLKNAPHPAL
910 920 930 940 950
MLATEPWPYP YSREVAAYPA PWLREYKFWP AVARIDNAYG DRHLVCTCSM

PLTN
Length:954
Mass (Da):103,795
Last modified:March 1, 2003 - v1
Checksum:i014E250CBE6ACF95
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000039 Genomic DNA. Translation: BAC09155.1.
RefSeqiNP_682393.1. NC_004113.1.

Genome annotation databases

EnsemblBacteriaiBAC09155; BAC09155; BAC09155.
GeneIDi1010570.
KEGGitel:tll1603.
PATRICi23928578. VBITheElo119873_1682.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000039 Genomic DNA. Translation: BAC09155.1 .
RefSeqi NP_682393.1. NC_004113.1.

3D structure databases

ProteinModelPortali Q8DII3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 197221.tll1603.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAC09155 ; BAC09155 ; BAC09155 .
GeneIDi 1010570.
KEGGi tel:tll1603.
PATRICi 23928578. VBITheElo119873_1682.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BP-1.

Entry informationi

Entry nameiGCSP_THEEB
AccessioniPrimary (citable) accession number: Q8DII3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: March 1, 2003
Last modified: October 1, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3