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Q8DII3

- GCSP_THEEB

UniProt

Q8DII3 - GCSP_THEEB

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Thermosynechococcus elongatus (strain BP-1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:tll1603
    OrganismiThermosynechococcus elongatus (strain BP-1)
    Taxonomic identifieri197221 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesThermosynechococcus
    ProteomesiUP000000440: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 954954Glycine dehydrogenase (decarboxylating)PRO_0000166940Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei706 – 7061N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi197221.tll1603.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8DII3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiFDSRPYS.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8DII3-1 [UniParc]FASTAAdd to Basket

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    MMVSSPPQLE INLETDAEFV ARHIGITPSD LPKMLSLLGY GSLKELINAV    50
    IPPEIRLQRP LALSEGLSET AALQKLRTLA QQNQVWRSYI GMGYYNCITP 100
    SVIQRNILEN PGWYTQYTPY QAEIAQGRLE ALLNFQTLVS DLTGLAIANA 150
    SLLDEATAAA EAMTLSFNAC RQRGANRFLV AQDCHPQTLA VLRTRALPLG 200
    IQIVPIDPIA GELPWENAFG LLLQYPASDG AVRSPQALIA AAHERGLLVT 250
    VATDLLALTL LRPPGELGAD IAVGSSQRFG VPLGYGGPHA AFFATREDFK 300
    RQLPGRLVGV SHDALGQRAL RLALQTREQH IRREKATSNI CTAQVLLAVV 350
    ASMYAVYHGP DGLRQIAERI HQRTVRLAAG LEAAGYQLYY SEFFDTLRIG 400
    LGNLPVPVLK ERAAAARINL RYFDDGSAGI SLDETTTEKD VADLLALFGA 450
    RPAEVEGGDR LPAALKRQSP YLQHPVFQDY HSEHALLRYI HRLQAKDLSL 500
    TTSMIPLGSC TMKLNATAEM LPISWPEFNQ LHPFAPQEQA QGYQALFREL 550
    AAMLAEITGF DAISLQPNAG SQGEYAGLLV IRQYHHSRGE SQRNVCLIPT 600
    SAHGTNPASA VMAGMQVVAV NCDAQGNIDV ADLAAKAETY GDRLAALMIT 650
    YPSTHGVFET GICQICDIIH RYGGQVYMDG ANMNAQVGLC RPGDFGADVC 700
    HLNLHKTFCI PHGGGGPGVG PIGVKAHLAP FLPTTQVIPQ GSETGPVTAA 750
    PWGSASILPI SWMYITLMGG VGLTRATAIA ILNANYIAKR LEPYYPVLYK 800
    GAHGLVAHEC ILDLRPLKKS AGIEVEDIAK RLMDYGFHAP TVSWPVPGTL 850
    MIEPTESETK AELDRFCEAM IAIRSEIAEI EAGVSDRQQN PLKNAPHPAL 900
    MLATEPWPYP YSREVAAYPA PWLREYKFWP AVARIDNAYG DRHLVCTCSM 950
    PLTN 954
    Length:954
    Mass (Da):103,795
    Last modified:March 1, 2003 - v1
    Checksum:i014E250CBE6ACF95
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000039 Genomic DNA. Translation: BAC09155.1.
    RefSeqiNP_682393.1. NC_004113.1.

    Genome annotation databases

    EnsemblBacteriaiBAC09155; BAC09155; BAC09155.
    GeneIDi1010570.
    KEGGitel:tll1603.
    PATRICi23928578. VBITheElo119873_1682.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000039 Genomic DNA. Translation: BAC09155.1 .
    RefSeqi NP_682393.1. NC_004113.1.

    3D structure databases

    ProteinModelPortali Q8DII3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 197221.tll1603.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAC09155 ; BAC09155 ; BAC09155 .
    GeneIDi 1010570.
    KEGGi tel:tll1603.
    PATRICi 23928578. VBITheElo119873_1682.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi FDSRPYS.
    OrthoDBi EOG6HMXDX.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BP-1.

    Entry informationi

    Entry nameiGCSP_THEEB
    AccessioniPrimary (citable) accession number: Q8DII3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3