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Q8DII3 (GCSP_THEEB) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:tll1603
OrganismThermosynechococcus elongatus (strain BP-1) [Reference proteome] [HAMAP]
Taxonomic identifier197221 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesThermosynechococcus

Protein attributes

Sequence length954 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 954954Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_0000166940

Amino acid modifications

Modified residue7061N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8DII3 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 014E250CBE6ACF95

FASTA954103,795
        10         20         30         40         50         60 
MMVSSPPQLE INLETDAEFV ARHIGITPSD LPKMLSLLGY GSLKELINAV IPPEIRLQRP 

        70         80         90        100        110        120 
LALSEGLSET AALQKLRTLA QQNQVWRSYI GMGYYNCITP SVIQRNILEN PGWYTQYTPY 

       130        140        150        160        170        180 
QAEIAQGRLE ALLNFQTLVS DLTGLAIANA SLLDEATAAA EAMTLSFNAC RQRGANRFLV 

       190        200        210        220        230        240 
AQDCHPQTLA VLRTRALPLG IQIVPIDPIA GELPWENAFG LLLQYPASDG AVRSPQALIA 

       250        260        270        280        290        300 
AAHERGLLVT VATDLLALTL LRPPGELGAD IAVGSSQRFG VPLGYGGPHA AFFATREDFK 

       310        320        330        340        350        360 
RQLPGRLVGV SHDALGQRAL RLALQTREQH IRREKATSNI CTAQVLLAVV ASMYAVYHGP 

       370        380        390        400        410        420 
DGLRQIAERI HQRTVRLAAG LEAAGYQLYY SEFFDTLRIG LGNLPVPVLK ERAAAARINL 

       430        440        450        460        470        480 
RYFDDGSAGI SLDETTTEKD VADLLALFGA RPAEVEGGDR LPAALKRQSP YLQHPVFQDY 

       490        500        510        520        530        540 
HSEHALLRYI HRLQAKDLSL TTSMIPLGSC TMKLNATAEM LPISWPEFNQ LHPFAPQEQA 

       550        560        570        580        590        600 
QGYQALFREL AAMLAEITGF DAISLQPNAG SQGEYAGLLV IRQYHHSRGE SQRNVCLIPT 

       610        620        630        640        650        660 
SAHGTNPASA VMAGMQVVAV NCDAQGNIDV ADLAAKAETY GDRLAALMIT YPSTHGVFET 

       670        680        690        700        710        720 
GICQICDIIH RYGGQVYMDG ANMNAQVGLC RPGDFGADVC HLNLHKTFCI PHGGGGPGVG 

       730        740        750        760        770        780 
PIGVKAHLAP FLPTTQVIPQ GSETGPVTAA PWGSASILPI SWMYITLMGG VGLTRATAIA 

       790        800        810        820        830        840 
ILNANYIAKR LEPYYPVLYK GAHGLVAHEC ILDLRPLKKS AGIEVEDIAK RLMDYGFHAP 

       850        860        870        880        890        900 
TVSWPVPGTL MIEPTESETK AELDRFCEAM IAIRSEIAEI EAGVSDRQQN PLKNAPHPAL 

       910        920        930        940        950 
MLATEPWPYP YSREVAAYPA PWLREYKFWP AVARIDNAYG DRHLVCTCSM PLTN 

« Hide

References

[1]"Complete genome structure of the thermophilic cyanobacterium Thermosynechococcus elongatus BP-1."
Nakamura Y., Kaneko T., Sato S., Ikeuchi M., Katoh H., Sasamoto S., Watanabe A., Iriguchi M., Kawashima K., Kimura T., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Nakazaki N., Shimpo S., Sugimoto M. expand/collapse author list , Takeuchi C., Yamada M., Tabata S.
DNA Res. 9:123-130(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: BP-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000039 Genomic DNA. Translation: BAC09155.1.
RefSeqNP_682393.1. NC_004113.1.

3D structure databases

ProteinModelPortalQ8DII3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING197221.tll1603.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAC09155; BAC09155; BAC09155.
GeneID1010570.
KEGGtel:tll1603.
PATRIC23928578. VBITheElo119873_1682.

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAFDSRPYS.
OrthoDBEOG6HMXDX.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_THEEB
AccessionPrimary (citable) accession number: Q8DII3
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families