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Q8DIB4 (DEF_THEEB) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Peptide deformylase
Short name=PDF
EC=3.5.1.88
Alternative name(s):
Polypeptide deformylase
Gene names
Name:def
Ordered Locus Names:tlr1676
OrganismThermosynechococcus elongatus (strain BP-1)
Taxonomic identifier197221 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Chroococcales › Thermosynechococcus

Protein attributes

Sequence length188 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions By similarity. HAMAP MF_00163

Catalytic activity

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide. HAMAP MF_00163

Cofactor

Binds 1 Fe2+ ion By similarity. HAMAP MF_00163

Sequence similarities

Belongs to the polypeptide deformylase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   LigandIron
Metal-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processtranslation

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functioniron ion binding

Inferred from electronic annotation. Source: InterPro

peptide deformylase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 188188Peptide deformylase HAMAP MF_00163
PRO_0000082863

Sites

Active site1501 By similarity
Metal binding1071Iron By similarity
Metal binding1491Iron By similarity
Metal binding1531Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8DIB4 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 1DD6999EFA0D29DC

FASTA18820,919
        10         20         30         40         50         60 
MAASLAVEKK KLKNPPLQLH YLGDRVLRQP AKRVSKVDDS IRDIARKMLQ TMYSADGIGL 

        70         80         90        100        110        120 
AAPQVGINKQ ILVIDIHPDD PEAEPLVMIN PVIKDFSEEL EVCQEGCLSI PGVYLEVRRP 

       130        140        150        160        170        180 
AMVEVSYKDE WGRPQVIMAG GLLARAIQHE IDHLTGVMFV DRVENQALLR HELKEHGFTA 


SAVRPIAA

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References

[1]"Complete genome structure of the thermophilic cyanobacterium Thermosynechococcus elongatus BP-1."
Nakamura Y., Kaneko T., Sato S., Ikeuchi M., Katoh H., Sasamoto S., Watanabe A., Iriguchi M., Kawashima K., Kimura T., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Nakazaki N., Shimpo S., Sugimoto M. expand/collapse author list , Takeuchi C., Yamada M., Tabata S.
DNA Res. 9:123-130(2002) [PubMed: 12240834] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: BP-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000039 Genomic DNA. Translation: BAC09228.1.
RefSeqNP_682466.1. NC_004113.1.

3D structure databases

ProteinModelPortalQ8DIB4.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ8DIB4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1010852.
GenomeReviewsGene locus tlr1676 in contig BA000039_GR.
KEGGtel:tlr1676.
NMPDRfig|197221.1.peg.1675.
PATRIC23928728. VBITheElo119873_1757.

Phylogenomic databases

eggNOGCOG0242.
HOGENOMHBG665227.
OMARITKVDE.
ProtClustDBPRK00150.

Enzyme and pathway databases

BioCycTELO197221:TLR1676-MONOMER.

Family and domain databases

HAMAPMF_00163. Pep_deformylase.
[Tree]
InterProIPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view]
Gene3DG3DSA:3.90.45.10. Fmet_deformylase. 1 hit.
KOK01462.
PANTHERPTHR10458. Fmet_deformylase. 1 hit.
PfamPF01327. Pep_deformylase. 1 hit.
[Graphical view]
PIRSFPIRSF004749. Pep_def. 1 hit.
PRINTSPR01576. PDEFORMYLASE.
SUPFAMSSF56420. Fmet_deformylase. 1 hit.
TIGRFAMsTIGR00079. Pept_deformyl. 1 hit.
ProtoNetSearch...

Entry information

Entry nameDEF_THEEB
AccessionPrimary (citable) accession number: Q8DIB4
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: March 1, 2003
Last modified: January 25, 2012
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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