Q8DI43 (EFG_THEEB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Elongation factor G
Short name=EF-G

Gene names

Name:	fusA
Synonyms:	fus
Ordered Locus Names:	tlr1749

Organism

Thermosynechococcus elongatus (strain BP-1)

Taxonomic identifier

197221 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Thermosynechococcus

Protein attributes

Sequence length	691 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome By similarity. HAMAP MF_00054_B
Subcellular location	Cytoplasm By similarity HAMAP MF_00054_B.
Sequence similarities	Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	GTP-binding Nucleotide-binding
Molecular function	Elongation factor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activity Inferred from electronic annotation. Source: InterPro translation elongation factor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 691	691	Elongation factor G HAMAP MF_00054_B		PRO_0000091240
Regions
	Nucleotide binding	17 – 24	8	GTP By similarity
	Nucleotide binding	81 – 85	5	GTP By similarity
	Nucleotide binding	135 – 138	4	GTP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8DI43 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: C1953428B6099A52	FASTA	691	76,307
	10 20 30 40 50 60 MARTTPLERV RNIGIAAHID AGKTTTTERI LFYSGVVHKI GEVHEGTTVT DWMEQERERG 70 80 90 100 110 120 ITITAAAIST SWRDHQINII DTPGHVDFTI EVERSMRVLD GVIAVFCSVG GVQPQSETVW 130 140 150 160 170 180 RQADRYSVPR IVFVNKMDRT GANFYKVHDQ IRDRLRANAV PIQLPIGAED QFKGIVDLVR 190 200 210 220 230 240 MRAKIYKDDL GKEIEDTEIP AEMTELAQEY RTKLIEAVAE TDDALMEKYF EGEELTEEEI 250 260 270 280 290 300 RAALRKGTIA GTIVPMLCGS AFKNKGVQLL LDAVVDYLPA PIDIPAIKGR LPDGTEVERA 310 320 330 340 350 360 ADDDQPLAAL AFKIMSDPYG RLTFVRVYSG VLKKGSYVLN ATKGKKERIS RLIVLKADER 370 380 390 400 410 420 IEVDELRAGD LGAALGLKET FTGDTLCDES SPVILESLYI PEPVISVAVE PKTKQDMEKL 430 440 450 460 470 480 SKALQALSEE DPTFRVSVDP ETNQTVIAGM GELHLEILVD RMQREYKVEA NIGQPQVAYR 490 500 510 520 530 540 ETIRKPVRAE GKFIRQSGGK GQYGHVVIEV EPAEPGTGFE FVSKIVGGVV PKEYIPPAEQ 550 560 570 580 590 600 GMKEACESGI LAGYPVIDLK VTLVDGSYHE VDSSEMAFKI AGSIAIKEAV MKANPVLLEP 610 620 630 640 650 660 MMKVEVEVPE EFLGTVMGDL IARRGQIEGQ TVENGIAKVT AKVPLERMFG YATDIRSNTQ 670 680 690 GRGIFSMEFS HYEEVPRNVA EAIIAKNKGN A

References

[1]

"Complete genome structure of the thermophilic cyanobacterium Thermosynechococcus elongatus BP-1." Nakamura Y., Kaneko T., Sato S., Ikeuchi M., Katoh H., Sasamoto S., Watanabe A., Iriguchi M., Kawashima K., Kimura T., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Nakazaki N., Shimpo S., Sugimoto M. , Takeuchi C., Yamada M., Tabata S. DNA Res. 9:123-130(2002) [PubMed: 12240834] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: BP-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000039 Genomic DNA. Translation: BAC09301.1.
RefSeq	NP_682539.1. NC_004113.1.
3D structure databases
ProteinModelPortal	Q8DI43.
SMR	Q8DI43. Positions 7-684.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8DI43.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1011972.
GenomeReviews	Gene locus tlr1749 in contig BA000039_GR.
KEGG	tel:tlr1749.
NMPDR	fig|197221.1.peg.1748.
PATRIC	23928878. VBITheElo119873_1830.
Phylogenomic databases
eggNOG	COG0480.
HOGENOM	HBG737692.
OMA	CNEWREK.
ProtClustDB	PRK00007.
Enzyme and pathway databases
BioCyc	TELO197221:TLR1749-MONOMER.
Family and domain databases
HAMAP	MF_00054_B. EF-G_EF-2_B. [Tree]
InterPro	IPR009022. Elongation_fac_G/III/V. IPR000795. ProtSyn_GTP-bd. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. IPR005225. Small_GTP-bd_dom. IPR004540. Transl_elong_EFG/EF2. IPR000640. Transl_elong_EFG/EF2_C. IPR005517. Transl_elong_EFG/EF2_IV. IPR004161. Transl_elong_EFTu/EF1A_2. IPR009000. Transl_elong_init/rib_B-barrel. [Graphical view]
Gene3D	G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit. G3DSA:3.30.70.240. Transl_elong_EFG/EF2_C. 1 hit.
KO	K02355.
Pfam	PF00679. EFG_C. 1 hit. PF03764. EFG_IV. 1 hit. PF00009. GTP_EFTU. 1 hit. PF03144. GTP_EFTU_D2. 1 hit. [Graphical view]
PRINTS	PR00315. ELONGATNFCT.
SMART	SM00838. EFG_C. 1 hit. SM00889. EFG_IV. 1 hit. [Graphical view]
SUPFAM	SSF54980. EFG_III_V. 2 hits. SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit. SSF50447. Translat_factor. 1 hit.
TIGRFAMs	TIGR00484. EF-G. 1 hit. TIGR00231. Small_GTP. 1 hit.
PROSITE	PS00301. EFACTOR_GTP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

EFG_THEEB

Accession

Primary (citable) accession number: Q8DI43

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 22, 2003
Last sequence update:	March 1, 2003
Last modified:	January 25, 2012
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program